1997-2000 Postdoctoral Fellow, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA
2000-2002.6 Research Associate, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA
2002.7-2007.8 Assistant Professor of Radiology, Harvard Medical School, Boston, MA
Dr. Takahashi has extensive experiences in radiological sciences, by means of magnetic resonance imaging (MRI) and computed tomography (CT) in clinical and preclinical settings. He has started his career in MRI field since 1990 in imaging of the brain at a pharmaceutical company where he was the chief in preclinical development of MRI contrst agents including gadlinium complexes and superparamagnetic iron oxyde (SPIO). During a three-year fellowship in the Department of Radiology at the University of Pennsylvania, he had been trained in MR microscopy and performed researches on osteoporosis and spinal cord injury. His researches were targeted at being able to image the process of degeneration that precedes physical disruption. Since he moved to the Beth Israel Deaconess Medical Center/Harvard Medical School in 2002, he has partly turned his attention to problems of the lung as MR imaging of the lung is extremely challenging because of the inherent difficulties associated with the organ. Specifically, he has been dedicated to the development of new acquisition and processing methods in animals and humans, permitting quantitative characterization of the pathophysiological change in pulmonary disorders, including lung cancer and parenchymal diseases such as chronic obstructive pulmonary disease (COPD). Since late 2007, he has also been involved in chemical exchange saturation transfer (CEST) which is the most practical molecluare imaging method by MRI in brain and lung cancers at the University of Texas Southwestern Medical Center.