Meet Dr. John Mansour
Surgical Oncologist

John Mansour, M.D., knows that he is a vital piece of the cancer care puzzle, and he brings his “A” game every day.

John Mansour, M.D., Surgical Oncologist

Dr. Mansour is a surgical oncologist on the nationally recognized gastrointestinal cancer team at UT Southwestern Medical Center’s Simmons Comprehensive Cancer Center. He treats patients with malignancies of the stomach, pancreas, liver, bile duct, and other abdominal organs.

He is the Chief of the Division of Surgical Oncology at UT Southwestern Medical Center and Associate Professor of Surgery. In his role as Leader of the Gastrointestinal Cancer Disease Oriented Team, he also moderates the Gastrointestinal Cancers Disease Oriented Team conference at Simmons Comprehensive Cancer Center and plays a major role in overseeing the clinical, research, and educational activities of the UTSW GI Cancer Programs.

I want my patients to be mini experts in their disease, so they understand not just what I’m recommending but why I’m recommending it to them. They’re making very big decisions, and I believe in keeping them informed.”

“To be a good surgical oncologist, you can’t be just one thing,” Dr. Mansour says. “You have to be a skilled surgeon and a scientist who understands what the next steps in cancer care are five, 10, 20 years down the line. You have to be an oncologist who understands cancer, chemotherapy, radiation therapy, and other therapies. And you need personal skills to bring together all of those pieces with a patient and their family, which is not always easy to do.” 

Patients leave Dr. Mansour’s office with two things: hope and a plan. He keeps them in the loop about all aspects of their care and encourages them to become mini experts in their diseases.

Dr. Mansour is passionate about quality health care. He’s part of a national team that measures how well doctors and hospitals are caring for patients with hepatobiliary cancers.

He is deeply involved in research on the genetic analysis of tumors and blood. It will help predict a tumor’s behavior, how aggressive it will be, and how well patients will tolerate a major operation, he says.

The future of cancer care is bright, Dr. Mansour says. He anticipates that the cutting-edge research being done today at UT Southwestern’s Simmons Cancer Center will allow doctors to treat cancers differently in the future.

“I anticipate that we will develop individualized treatment for each patient that will, hopefully, help them live longer,” he says.

Clinical Interests/Specialties

  • Gastric cancer
  • Pancreas cancer
  • Liver cancer
  • Metastatic colon cancer
  • Retroperitoneal and extremity sarcoma
  • Gastrointestinal stromal tumor (GIST)
  • Bile duct cancer
  • Cholangiocarcinoma
  • Ampullary cancer
  • Whipple procedure
  • Liver resection
  • Gastrectomy
  • Laparoscopic liver resection
  • Laparoscopic pancreas resection
  • Laparoscopic splenectomy