Changho Choi, Ph.D., received his Bachelor of Science degree in 1987 from Korea University, South Korea. He then earned a Ph.D. from the University of Waterloo, Canada, where he used nuclear magnetic resonance for studying quantum tunneling of protons at low temperatures. Following several years of research in in-vivo MR spectroscopy (MRS), he joined the Advanced Imaging Research Center at UT Southwestern Medical Center in 2007.
Dr. Choi’s research has been focused on both technical and clinical developments of MR spectroscopy in brain tumors and neuropsychiatric disorders. MRS methodology development has been carried out to provide meaningful measurements of clinically-important hard-to-detect brain metabolites, including 2-hydroxyglutarate (2HG), citrate, GABA, glycine, glutamate and glutamine, etc. Specifically, 2HG, which is a direct consequence of IDH mutation in gliomas, appears to be an unprecedented imaging biomarker in brain tumors.
Research is going on to accomplish a fast, high-precision 2HG imaging modality, in parallel with translation of previously-developed methods into clinics. The clinical utility of 2HG, glycine and citrate in brain tumors is investigated in collaboration with neuro-oncologists. Also, several MRS studies are conducted to evaluate the alterations in metabolic profiles in neurological diseases, including schizophrenia, asthma and autism, in collaboration with psychiatrists.
- Korea University (1987), Physics
- Graduate School
- Korea University (1989)
- Graduate School
- University of Waterloo (1996), Physics
- Applications of MRS in cancer and neuropsychiatric diseases
- In vivo 1H and 13C MR spectroscopy
- Quantum mechanical simulations of spin dynamics
- RF pulse and MRS sequence design
- In vivo 1H MR spectroscopic imaging of glycine in brain tumors at 3T
- Ganji SK, Maher EA, Choi C Magn Reson Med 2015 (in press)
- Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7?T in vivo.
- Ganji SK, An Z, Banerjee A, Madan A, Hulsey KM, Choi C NMR Biomed 2014 Aug
- 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas.
- Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo RM, Maher EA Nat. Med. 2012 Apr 18 4 624-9
- (1) H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors.
- Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C NMR Biomed 2014 Nov
- Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia.
- Stan AD, Ghose S, Zhao C, Hulsey K, Mihalakos P, Yanagi M, Morris SU, Bartko JJ, Choi C, Tamminga CA Mol. Psychiatry 2014 Jun
- Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3T in vivo
- Madan A, Ganji SK, An Z, Choe K, Pinho M, Bachoo, RM, Maher EM, Choi C Magn Reson Med 2014 Epub ahead of print
- In vivo detection of citrate in brain tumors by (1) H magnetic resonance spectroscopy at 3T.
- Choi C, Ganji SK, Madan A, Hulsey KM, An Z, Zhang S, Pinho MC, Deberardinis RJ, Bachoo RM, Maher EA Magn Reson Med 2013 Oct
- A comparative study of short- and long-TE (1) H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
- Choi C, Ganji S, Hulsey K, Madan A, Kovacs Z, Dimitrov I, Zhang S, Pichumani K, Mendelsohn D, Mickey B, Malloy C, Bachoo R, Deberardinis R, Maher E NMR Biomed 2013 Apr
- Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T.
- Banerjee A, Ganji S, Hulsey K, Dimitrov I, Maher E, Ghose S, Tamminga C, Choi C Magn Reson Med 2012 Aug 68 2 325-31
- Observation of CH3 tunneling manifold by level-crossing NMR
- Choi C, Pintar MM Physical Review Letters 1996 76 527-530