Cheng-Ming Chiang was born in Taipei, Taiwan in 1961. He received his BS from the Department of Agricultural Chemistry, National Taiwan University, in 1984, and his PhD from the Department of Biochemistry, University of Rochester, in 1991. His doctoral dissertation was supervised by Professors Louise Chow and Thomas Broker. After finishing his postdoctoral training with Professor Robert Roeder at Rockefeller University, he took a faculty position in the Department of Biochemistry at University of Illinois, Urbana-Champaign in 1995. In 2000, he moved to Department of Biochemistry at Case Western Reserve University as tenured Associate Professor.
Dr. Chiang accepted a Professorship at UT Southwestern and relocated his laboratory to UT Southwestern in July 2007.
Dr. Chiang is a 1996 Pew Scholar and has been an editorial board member of the Journal of Biological Chemistry and Faculty of 1000 since 2003. He has been a regular member for American Cancer Society Genetic/DNA Mechanisms in Cancer, National Institutes of Health Virology B, and Human Frontier Science Program study sections. His research interests span transcription, chromatin, gene regulation, and virology.
- National Taiwan University , Chemistry
- Graduate School
- University of Rochester , Biochemistry
- Brd4 in Epigenetic Control and Cancer Therapeutics
- Chromatin Transcription and Posttranslational Modification
- Gene Regulation in Human Papillomaviruses (HPVs)
- Human General Transcription Factors and Cofactors in Eukaryotic Transcription
- p53 Tumor Suppressor Function and Regulation
- Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting.
- Wu SY, Lee AY, Lai HT, Zhang H, Chiang CM Mol. Cell 2013 Jan
- p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability.
- Chiang CM Cell Cycle 2012 Oct 11 20 3719-20
- Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription.
- Wang WM, Wu SY, Lee AY, Chiang CM J. Biol. Chem. 2011 Nov 286 47 40974-86
- Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding.
- Wu SY, Chiang CM EMBO J. 2009 May 28 9 1246-59
- Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability.
- Lee AY, Chiang CM J. Biol. Chem. 2009 Jan 284 5 2778-86
- Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.
- Chiang CM F1000 Biol Rep 2009 1 98
- The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation.
- Wu SY, Chiang CM J. Biol. Chem. 2007 May 282 18 13141-5
- Brd4 links chromatin targeting to HPV transcriptional silencing.
- Wu SY, Lee AY, Hou SY, Kemper JK, Erdjument-Bromage H, Tempst P, Chiang CM Genes Dev. 2006 Sep 20 17 2383-96
- The general transcription machinery and general cofactors.
- Thomas MC, Chiang CM Crit. Rev. Biochem. Mol. Biol. 2006 May-Jun 41 3 105-78
- E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation.
- Thomas MC, Chiang CM Mol. Cell 2005 Jan 17 2 251-64
Honors & Awards
- Mt. Sinai Health Care Foundation Scholar
Case Western Reserve University (2000)
- Pew Scholar in the Biomedical Sciences
Pew Charitable Trust (1996)
- Postdoctoral Fellow
Helen Hay Whitney Foundation (1993)
- Postdoctoral Fellow
Aaron Diamond Foundation (1993)
- The Wallace O. Fenn Award
University of Rochester (1991)