Biography

Dr. Huo obtained her M.D. from North China Coal Medical College (1999) and her Ph.D. from Peking Union Medical College (2005). After completing her Ph.D. she did her postdoctoral training in Internal Medicine—Liver and Digestive Diseases at the University of Texas Southwestern Medical Center at Dallas (2007-2012).

Dr. Huo has a particular interest in understanding the early pathophysiology of Gastroesophageal reflux disease (GERD) at the cellular and molecular levels so that new medical treatments can be developed to improve symptom control, to eliminate inflammation, and to prevent the development of Barrett’s esophagus and esophageal adenocarcinoma.

Education

Undergraduate North China Coal Medical College (1999), Medicine
Graduate School Zunyi Medical College (2002), Biochemistry
Graduate School Chinese Academy of Medical Sciences & Peking Union (2005), Molecular Biology

Research Interest

  • Barrett's esophagus
  • Esophageal adenocarcinoma
  • Reflux esophagitis

Publications

Featured Publications LegendFeatured Publications

Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.
Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Wang DH, Spechler SJ, Souza RF Gut 2012 May
Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells.
Zhang X, Cheng E, Huo X, Yu C, Zhang Q, Pham TH, Wang DH, Spechler SJ, Souza RF PLoS ONE 2012 7 11 e50037
Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-?B activation in benign Barrett's epithelial cells.
Huo X, Juergens S, Zhang X, Rezaei D, Yu C, Strauch ED, Wang JY, Cheng E, Meyer F, Wang DH, Zhang Q, Spechler SJ, Souza RF Am. J. Physiol. Gastrointest. Liver Physiol. 2011 Aug 301 2 G278-86
Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.
Huo X, Zhang HY, Zhang XI, Lynch JP, Strauch ED, Wang JY, Melton SD, Genta RM, Wang DH, Spechler SJ, Souza RF Gastroenterology 2010 Jul 139 1 194-203.e1
Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury.
Souza RF, Huo X, Mittal V, Schuler CM, Carmack SW, Zhang HY, Zhang X, Yu C, Hormi-Carver K, Genta RM, Spechler SJ Gastroenterology 2009 Nov 137 5 1776-84

Honors & Awards

  • Fellow Travel Award
    Gastroenterology Research Group (GRG) (2010)
  • Outstanding M.S. Candidate
    Peking Union Medical College, China (2001)
  • Outstanding M.S. Candidate
    Peking Union Medical College, China (2001)
  • Outstanding M.S. Candidate
    Peking Union Medical College, China (2000)

Professional Associations/Affiliations

  • American Gastroenterological Association (2010)