Featured Publications
A labeled substrate approach to discovery of biocatalytic reactions: a proof of concept transformation with N-methylindole.
Rogers JL, Macmillan JB J. Am. Chem. Soc. 2012 Aug 134 30 12378-81
Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis.
Pan E, Jamison M, Yousufuddin M, MacMillan JB Org. Lett. 2012 May 14 9 2390-3
Erythrolic acids A-E, Meroterpenoids from a Marine-Derived Erythrobacter sp.
Hu Y, Legako AG, Espindola AP, Macmillan JB The Journal of organic chemistry 2012 Mar
Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.
Hu Y, MacMillan JB Org. Lett. 2011 Dec 13 24 6580-3
Chromomycin SA analogs from a marine-derived Streptomyces sp.
Hu Y, Espindola AP, Stewart NA, Wei S, Posner BA, MacMillan JB Bioorg. Med. Chem. 2011 Sep 19 17 5183-9
Towards patient-based cancer therapeutics.
Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA Nat. Biotechnol. 2010 Sep 28 9 904-6
Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC).
Espindola AP, Crouch R, DeBergh JR, Ready JM, MacMillan JB J. Am. Chem. Soc. 2009 Nov 131 44 15994-5
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.
Chiu YH, Macmillan JB, Chen ZJ Cell 2009 Aug 138 3 576-91
Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.
Maloney KN, Macmillan JB, Kauffman CA, Jensen PR, Dipasquale AG, Rheingold AL, Fenical W Org. Lett. 2009 Dec 11 23 5422-4
Ammosamides A and B target myosin.
Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ Angew. Chem. Int. Ed. Engl. 2009 48 4 728-32
