Dr. Sarvjeet Singh received his Ph.D. (Molecular Biology) in 2007 from one of India’s preeminent biomedical institutions, the Center for Cellular and Molecular Biology (CCMB) located in Hyderabad, India. Dr. Singh’s doctoral work was performed under the guidance of Dr. Ashok Khar, one of India’s renowned immunologists and who is the former Deputy Director of CCMB. Sarvjeet’s Ph.D. work focused on the role of apoptosis in tumor biology. From 2007 to 2013, Dr. Singh was a postdoctoral research fellow in the Mammen Laboratory at UT Southwestern Medical Center. Under the guidance of Dr. Pradeep Mammen, his postdoctoral work focused on investigating the role of redox signaling in modulating myocyte proliferation and differentiation. Dr Singh’s postdoctoral work was partially funded by an American Heart Association Postdoctoral Research Fellowship Grant Award (2009-2011). In addition, he was selected as a finalist for the 2010 Louis N. and Arnold M. Katz Basic Science Research Award. This Award is sponsored by the American Heart Association and represents the highest honor that can be bestowed upon a junior investigator. Finally, in February of 2013, Dr. Singh joined the cardiology research faculty at UT Southwestern Medical Center. Currently, his research efforts are focused on further enhancing our understanding of the molecular mechanisms that regulate skeletal muscle and cardiac growth and regeneration under basal and pathologic conditions.
|Undergraduate||University of Delhi (1998), Biology|
|Graduate School||"hamdard University, Delhi , India" (2000), Biochemistry|
|Graduate School||Jamia Hamdard University (2000), Biology|
|Graduate School||University of Hyderabad - India (2006), Molecular Biology|
|Graduate School||(2006), Molecular Cell Biology|
- Cardiac Hypertrophy
- Cell Cycle
- Redox Signaling and Homeostasis
- Regeneration and Growth
- Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.
- Singh S, Canseco DC, Manda SM, Shelton JM, Chirumamilla RR, Goetsch SC, Ye Q, Gerard RD, Schneider JW, Richardson JA, Rothermel BA, Mammen PP Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 E129-38
- Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance.
- Quintens R, Singh S, Lemaire K, De Bock K, Granvik M, Schraenen A, Vroegrijk IO, Costa V, Van Noten P, Lambrechts D, Lehnert S, Van Lommel L, Thorrez L, De Faudeur G, Romijn JA, Shelton JM, Scorrano L, Lijnen HR, Voshol PJ, Carmeliet P, Mammen PP, Schuit F PLoS ONE 2013 8 2 e56719
- Calcineurin activates cytoglobin transcription in hypoxic myocytes.
- Singh S, Manda SM, Sikder D, Birrer MJ, Rothermel BA, Garry DJ, Mammen PP J. Biol. Chem. 2009 Apr 284 16 10409-21
- Activation of NFkappaB and Ub-proteasome pathway during apoptosis induced by a serum factor is mediated through the upregulation of the 26S proteasome subunits.
- Singh S, Khar A Apoptosis 2006 May 11 5 845-59
- Biological effects of curcumin and its role in cancer chemoprevention and therapy.
- Singh S, Khar A Anticancer Agents Med Chem 2006 May 6 3 259-70
- Differential gene expression during apoptosis induced by a serum factor: role of mitochondrial F0-F1 ATP synthase complex.
- Singh S, Khar A Apoptosis 2005 Dec 10 6 1469-82
- Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
- Rotter D, Grinsfelder DB, Parra V, Pedrozo Z, Singh S, Sachan N, Rothermel BA J. Mol. Cell. Cardiol. 2014 May
- Immunomodulatory and therapeutic activity of curcumin.
- Srivastava RM, Singh S, Dubey SK, Misra K, Khar A Int. Immunopharmacol. 2011 Mar 11 3 331-41
- Immunomodulatory effects of curcumin: in-vivo.
- Varalakshmi Ch, Ali AM, Pardhasaradhi BV, Srivastava RM, Singh S, Khar A Int. Immunopharmacol. 2008 May 8 5 688-700
- Antitumour immune responses.
- Mitra R, Singh S, Khar A Expert Rev Mol Med 2003 Jan 5 3 1-19
Honors & Awards
- The Louis N. and Arnold M. Katz Basic Science Research Award Finalist
Competitive award for young investigators in basic cardiovascular research, sponsored by the AHA (2010)
- AHA South Central Postdoctoral Research Award
Postdoctoral Fellowship (2009)
- New Investigator Travel Award
Competitive award from the American Heart Association to attend the 2009 AHA Basic Cardiovascular Symposium (2009)
- International Travel Award
Travel and supportive grant from the Government of India and Cold Spring Harbor Laboratory to attend the 6th Conference on Programmed Cell Death (2005)
- National Eligibility Test Scholarship
Predoctoral Fellowship (2001)
- Sigma Xi (2012)
- AAAS (2010)
- American Heart Association (2009)