Pier Scaglioni, M.D.

Dr. Pier Paolo Scaglioni received his M.D. degree in 1989 from the University of Modena, Italy. After completing a residency in Internal Medicine at the University of Modena in, in 1993 he joined as a post-doctoral associate the laboratory of Dr. Jack R. Wands at the Massachusetts General Hospital Cancer Center where he studied the mechanisms leading to hepatitis B virus induced liver disease. Subsequently, Dr. Scaglioni the residency program in Internal Medicine at the Albert Einstein Medical College (1998-2001) and a Fellowship in Hematology/Oncology at the Memorial Sloan-Kettering Cancer Center (2001-2005). During oncology training he focused his interests on hemopoietic malignancies and in 2002 he joined the laboratory of Dr. Pier Paolo Pandolfi where he initiated studies to elucidate the mechanisms controlling the Promyelocytic Leukemia gene tumor suppressive function. In 2005 Dr. Scaglioni joined as a Faculty Member the Hematology Service of Memorial-Sloan Kettering Cancer Center. In October 2006, Dr. Scaglioni became an Assistant Professor in the Department of Medicine, Division of Hematology/Oncology of the UT Southwestern Medical Center. He is leading the Cancer Signaling Laboratory of the Simmons Cancer Center while maintaining a limited oncology practice in the Bone Marrow Transplant program at UTSW. Dr. Scaglioni has received several Awards including the ASCO Young Investigator Award, the CALGB Oncology Fellows Award, the Michael and Ethel L. Cohen Fellowship and the Charles A. Dana Clinical Scholarship. Dr. Scaglioni enjoys outdoor activities and spending time with his wife and daughter.

Medical School	Universita' Degli Studi Di Modena (1989)
Residency	Montefiore Medical Center (2001), Internal Medicine
Fellowship	Memorial Sloan-Kettering Cancer Center (2004), Hematology and Oncology

• Primary Interests
• Acute Myelogeneous Leukemia
• Bone Marrow Transplant (BMT)
• Myeloproliferative Disorders

Featured Publications

A CK2-dependent pathway for PML degradation upon cellular and oncogenic stress

P.P. Scaglioni, T. Yung, L. F. Cai, H. Erdjument-Bromage, P. Tempst, J. Teruya-Feldstein, P.P. Pandolfi Cell 2006 126 269-83

In vivo analysis of the role of aberrant histone deacetylase recruitment and RARalpha blocade in the pathogenesis of acute promyelocytic leukemia

H. Matsushita, P.P. Scaglioni, M. Bhaumik, E.M. Rego, L.F. Cai, Hayato Miyachi, A. Kakizuka, W.H. Miller, P.P. Pandolfi J Exp Med 2006 17 821-828

Identification of a tumor suppressor network opposing nuclear Akt function

L.C. Trotman, A. Alimonti, P.P. Scaglioni, J.A. Koutcher, C. Cordon-cardo, P.P. Pandolfi Nature 2006 25 523-527

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

R. Bernardi, P.P. Scaglioni, S. Bergmann, H.F. Horn, K.H. Vousden and P.P Pandolfi Nature Cell Biology 2004 6 665-672

Taking apart a cancer protein

P.P. Scaglioni and P.p. Pandolfi Nature 2003 426 512-13

• ASH
  Travel Award (2004)
• Charles A. Dana Fellow
  Clinical Scholars Training Program in Biomedical Research (2004)
• ASCO
  Young Investigator Award (2003)
• CALGB
  Oncology Fellows Award (2003)
• Montefiore Medical Center/A. Einstein College of Medicine
  Citation in Recognition as an outstanding House Officer (2001)