Biography

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Dr. Brion has published more than 60 original research manuscripts. During his training in pediatrics and in neonatology, he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at AECOM, he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth.

Dr. Brion’s academic focus later changed to clinical research assessing neonatal mortality and morbidity and evidence-based medicine. He is a member of the Neonatal Cochrane Collaboration Group. He has authored several Cochrane reviews and has participated in 3 randomized controlled trials (RCTs) in preterm infants. Dr. Brion has served on the IRB at AECOM. He has participated in several multi-center research studies. Since 2009, he has been the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN). Dr. Brion serves on the subcommittee on protection of human subjects of the NRN, is co-investigator in 3 protocols in the pipeline, and has reviewed 4 manuscripts. He has co-authored two manuscripts published by the NRN: one pilot randomized trial on vitamin E (Bell E et al, Pediatrics. 2013 Dec;132(6):e1626-33. PMID:24218460) and one study that showed changes in practice after a randomized trial (LeVan et al, Arch Dis Child Fetal Neonatal 2014;99: F386–F390. PMID: 24876196, see C4 below). 

In January 2015, Dr. Brion obtained 2-year funding from Children’s Medical Center Foundation at Dallas for studies aiming at analyzing the relationship between neonatal nutrition, growth, neurodevelopment and signs suggestive of metabolic syndrome in high-risk preterm infants. These studies include (1) a quality improvement project (bundle including utilization of new growth curves, serial accurate length measurements using stadiometer or infantometer) and optimized nutrition (adjusting nutrients based on growth, blood urea nitrogen and albumin) and (2) a randomized trial comparing optimized nutrition with individualized (based on daily measurements of macronutrients in mothers’ own breast milk) and optimized nutrition.

Dr. Brion has been Director of the Fellowship Training Program in Neonatal-Perinatal Medicine, first at AECOM in 1997-2006 and currently at UTSW since 2007. He has been research mentor for more than 25 trainees. He is one of 4 neonatologists who teach an evidence-based medicine course twice a month for Fellows in Neonatal-Perinatal Medicine at UTSW.

In 2013 Dr. Brion took the Clinical Safety and Efficacy Course at UTSW. He supervises a team of research nurses who maintain the Divisional extensive neonatal intensive care unit (NICU) clinical databases at Parkland and Children’s Medical Center and databases for the Vermont Oxford Neonatal Network (VON) and Children’s Hospital Network Database (CHND). He compiles and presents an Annual Report of mortality and morbidity of neonates admitted to Parkland NICU and compares them to those of the NICHD NRN, VON and national data. He has used the databases for quality improvement and for research, including preliminary data for the proposed research.

Education

Medical School
Universite Libre de Bruxelles (1976)
Residency
Hopital Universitaire Saint-Pierre (1979), Pediatrics
Residency
Institut Edith Cavell (1981), Pediatrics
Fellowship
Hospital for Sick Children (1982), Neonatal-perinatal Medicine
Fellowship
Institut Edith Cavell (1982), Neonatal-perinatal Medicine
Fellowship
Cliniques Universitaires (1983), Neonatal-perinatal Medicine
Fellowship
Albert Einstein College of Medicine/Montefiore Medical Center (1985), Neonatal-perinatal Medicine
Residency
Montefiore Medical Center/ Albert Einstein College of Medicine (1986), Pediatrics

Specialty Areas

Clinical Interest

  • Interventions to Reduce Morbidity in Preterm Infants
  • Research Interest

    • Evidence-based medicine
    • Interventions to reduce mortality and morbidity in neonates
    • Neonatal nutrition and growth

    Publications

    Featured Publications LegendFeatured Publications

    Index of Suspicion in the Nursery: Progressive lethargy in a four-day-old term infant
    Weydig HM, Veltkamp D, Kakkilaya V, Stumpf K, Waber LJ, Brion LP NeoReviews 2015 Nov 16 11
    The association of congenital heart disease with necrotizing enterocolitis in preterm infants: a birth cohort study.
    Motta C, Scott W, Mahony L, Koch J, Wyckoff M, Reisch J, Burchfield PJ, Brion LP J Perinatol 2015 Aug
    Index of suspicion. Hyperbilirubinemia without jaundice in a neonate
    Sen SK, Mayor R, Engle WD, Blumenschein SD, Brion LP. NeoReviews 2015 Aug 16 8
    Hypomagnesemia secondary to cerebrospinal fluid losses in a patient with congenital hydrocephalus.
    Lal CV, Mir IN, Kelley E, Weprin BE, Sengupta AL, Booth TN, Brion LP J Perinatol 2014 Aug 34 8 640-1
    Change in practice after the Surfactant, Positive Pressure and Oxygenation Randomised Trial.
    LeVan JM, Brion LP, Wrage LA, Gantz MG, Wyckoff MH, Sánchez PJ, Heyne R, Jaleel M, Finer NN, Carlo WA, Das A, Stoll BJ, Higgins RD Arch. Dis. Child. Fetal Neonatal Ed. 2014 May
    Serum Tocopherol Levels in Very Preterm Infants After a Single Dose of Vitamin E at Birth.
    Bell EF, Hansen NI, Brion LP, Ehrenkranz RA, Kennedy KA, Walsh MC, Shankaran S, Acarregui MJ, Johnson KJ, Hale EC, Messina LA, Crawford MM, Laptook AR, Goldberg RN, Van Meurs KP, Carlo WA, Poindexter BB, Faix RG, Carlton DP, Watterberg KL, Ellsbury DL, Das A, Higgins RD Pediatrics 2013 Nov
    Change in Care Among Nonenrolled Patients During and After a Randomized Trial.
    Levan JM, Wyckoff MH, Ahn C, Heyne R, Sánchez PJ, Chalak L, Jaleel MA, Burchfield PJ, Christie L, Soll R, Badger GJ, Brion LP Pediatrics 2013 Sep
    Perinatal Asphyxia with Hyperoxemia within the First Hour of Life Is Associated with Moderate to Severe Hypoxic-Ischemic Encephalopathy.
    Kapadia VS, Chalak LF, Dupont TL, Rollins NK, Brion LP, Wyckoff MH J. Pediatr. 2013 Jun
    Perinatal Acidosis and Hypoxic-Ischemic Encephalopathy in Preterm Infants of 33 to 35 Weeks' Gestation.
    Chalak LF, Rollins N, Morriss MC, Brion LP, Heyne R, Sánchez PJ J. Pediatr. 2011 Oct
    Routine use of diuretics in very-low birth-weight infants in the absence of supporting evidence.
    Stewart AL, Brion LP J Perinatol 2011 Oct 31 10 633-4

    Books

    Featured Books Legend Featured Books

    Neonatal jaundice. In McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, DeWitt TG, eds. AAP Textbook of Pediatric Care.

    Kapadia VS, Brion LP. (2015). Elk Grove Village, IL: American Academy of Pediatrics.

    Clinical significance of developmental renal physiology. In Fetal and Neonatal Physiology

    Brion LP, Satlin LM (1998). Philadelphia, PA: Saunders.

    Kidney and Urinary Tract. In Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine.

    Brion LP, Bernstein J, Spitzer A. (1997). St. Louis, MO: Mosby.

    Renal disease. In Avery's Neonatology: Pathophysiology and Management of the Newborn.

    Nafday S, Brion LP, Benchimol C, Satlin LM, Flynn J, Edelmann CM Jr. (2004). Philadelphia, PA: JB Lippincott Company.

    Renal disease. In MacDonald MG, Mullett MD, Seshia MMK, eds. Avery's Neonatology: Pathophysiology and Management of the Newborn

    Nafday SM, Woda CB, Saland JM, Flynn JT, Askenzi D, Benchimol C, Brion LP. (2015). Philadelphia, PA: JB Lippincott Company.

    Neonatal Jaundice. In Campbell DE, ed. Neonatology for Primary Care.

    Kapadia VS, Brion LP. (2015). Elk Grove Village, IL: American Academy of Pediatrics.

    Neonatal jaundice in the term and near term infant. In TK McInerny, HM Adam, DE Campbell, DM Kamat, KJ Kelleher, eds. American Academy of Pediatrics Textbook of Pediatric Care.

    Brion LP. (2009). Elk Grove Village, IL: American Academy of Pediatrics.

    Renal Disease. In MacDonald MG, ed. Neonatology: Pathophysiology and Management of the Newborn.

    Brion LP, Satlin LM, Edelmann CM Jr. (1999). Philadelphia, PA: JB Lippincott Company.

    Honors & Awards

    • Elected to American Pediatric Society
      (2015)
    • Recognition by program directors for special contribution
      COGME, Albert Einstein College of Medicine, Bronx, NY (2006)
    • Best Doctors in America
      (2003-2014)
    • America's Registry of Outstanding Professionals
      (2002-2003)
    • New York Metro Area Top Doctors
      Castle Connolly Medical Ltd (2001-2005)

    Professional Associations/Affiliations

    • American Pediatric Society (2014)
    • American Academy of Pediatrics
    • American Medical Association
    • Society of Pediatric Research