Biography

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Dr. Brion has published more than 60 original research manuscripts. During his training in pediatrics and in neonatology, he participated and conducted studies on growth, nutrition and assessment of renal function in neonates and children. As Faculty at AECOM, he was funded for years by the NIH, American Heart Association, Genentech Foundation, and Pharmacia for basic sciences research in developmental nephrology, specifically renal acid secretion, carbonic anhydrase, pathophysiological effects of acidosis and growth.

Dr. Brion’s academic focus later changed to clinical research assessing neonatal mortality and morbidity and evidence-based medicine. He is a member of the Neonatal Cochrane Collaboration Group. He has authored several Cochrane reviews and has participated in 3 randomized controlled trials (RCTs) in preterm infants. Dr. Brion has served on the IRB at AECOM. He has participated in several multi-center research studies. Since 2009, he has been the University of Texas Southwestern (UTSW) Alternate PI for the NICHD Eunice Kennedy Shriver Cooperative Multicenter Neonatal Research Network (NRN). Dr. Brion serves on the subcommittee on protection of human subjects of the NRN, is co-investigator in 3 protocols in the pipeline, and has reviewed 4 manuscripts. He has co-authored two manuscripts published by the NRN: one pilot randomized trial on vitamin E (Bell E et al, Pediatrics. 2013 Dec;132(6):e1626-33. PMID:24218460) and one study that showed changes in practice after a randomized trial (LeVan et al, Arch Dis Child Fetal Neonatal 2014;99: F386–F390. PMID: 24876196, see C4 below). 

In January 2015, Dr. Brion obtained 2-year funding from Children’s Medical Center Foundation at Dallas for studies aiming at analyzing the relationship between neonatal nutrition, growth, neurodevelopment and signs suggestive of metabolic syndrome in high-risk preterm infants. These studies include (1) a quality improvement project (bundle including utilization of new growth curves, serial accurate length measurements using stadiometer or infantometer) and optimized nutrition (adjusting nutrients based on growth, blood urea nitrogen and albumin) and (2) a randomized trial comparing optimized nutrition with individualized (based on daily measurements of macronutrients in mothers’ own breast milk) and optimized nutrition.

Dr. Brion has been Director of the Fellowship Training Program in Neonatal-Perinatal Medicine, first at AECOM in 1997-2006 and currently at UTSW since 2007. He has been research mentor for more than 25 trainees. He is one of 4 neonatologists who teach an evidence-based medicine course twice a month for Fellows in Neonatal-Perinatal Medicine at UTSW.

In 2013 Dr. Brion took the Clinical Safety and Efficacy Course at UTSW. He supervises a team of research nurses who maintain the Divisional extensive neonatal intensive care unit (NICU) clinical databases at Parkland and Children’s Medical Center and databases for the Vermont Oxford Neonatal Network (VON) and Children’s Hospital Network Database (CHND). He compiles and presents an Annual Report of mortality and morbidity of neonates admitted to Parkland NICU and compares them to those of the NICHD NRN, VON and national data. He has used the databases for quality improvement and for research, including preliminary data for the proposed research.

Education

Medical School
Universite Libre de Bruxelles (1976)
Residency
Hopital Universitaire Saint-Pierre (1979), Pediatrics
Residency
Institut Edith Cavell (1981), Pediatrics
Fellowship
Hospital for Sick Children (1982), Neonatal-perinatal Medicine
Fellowship
Institut Edith Cavell (1982), Neonatal-perinatal Medicine
Fellowship
Cliniques Universitaires (1983), Neonatal-perinatal Medicine
Fellowship
Albert Einstein College of Medicine/Montefiore Medical Center (1985), Neonatal-perinatal Medicine
Residency
Montefiore Medical Center/ Albert Einstein College of Medicine (1986), Pediatrics

Specialty Areas

Clinical Interest

  • Interventions to Reduce Morbidity in Preterm Infants
  • Research Interest

    • Evidence-based medicine
    • Interventions to reduce mortality and morbidity in neonates
    • Neonatal nutrition and growth

    Publications

    Featured Publications LegendFeatured Publications

    Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support.
    James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H J. Pediatr. 2017 Jun
    Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation.
    Chawla S, Natarajan G, Shankaran S, Carper B, Brion LP, Keszler M, Carlo WA, Ambalavanan N, Gantz MG, Das A, Finer N, Goldberg RN, Cotten CM, Higgins RD J. Pediatr. 2017 Jun
    Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants.
    Jensen EA, Dysart KC, Gantz MG, Carper B, Higgins RD, Keszler M, Laughon MM, Poindexter BB, Stoll BJ, Walsh MC, Schmidt B J. Pediatr. 2017 Feb
    Survival and Neurodevelopmental Outcomes among Periviable Infants.
    Younge N, Goldstein RF, Bann CM, Hintz SR, Patel RM, Smith PB, Bell EF, Rysavy MA, Duncan AF, Vohr BR, Das A, Goldberg RN, Higgins RD, Cotten CM N. Engl. J. Med. 2017 02 376 7 617-628
    Severe intraventricular hemorrhage and withdrawal of support in preterm infants.
    Sheehan JW, Pritchard M, Heyne RJ, Brown LS, Jaleel MA, Engle WD, Burchfield PJ, Brion LP J Perinatol 2016 Dec
    Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.
    Navarrete CT, Wrage LA, Carlo WA, Walsh MC, Rich W, Gantz MG, Das A, Schibler K, Newman NS, Piazza AJ, Poindexter BB, Shankaran S, Sánchez PJ, Morris BH, Frantz ID, Van Meurs KP, Cotten CM, Ehrenkranz RA, Bell EF, Watterberg KL, Higgins RD, Duara S J. Pediatr. 2016 Jun
    Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.
    Massaro AN, Murthy K, Zaniletti I, Cook N, DiGeronimo R, Dizon ML, Hamrick SE, McKay VJ, Natarajan G, Rao R, Richardson T, Smith D, Mathur AM J. Pediatr. 2016 Mar
    Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections.
    Wortham JM, Hansen NI, Schrag SJ, Hale E, Van Meurs K, Sánchez PJ, Cantey JB, Faix R, Poindexter B, Goldberg R, Bizzarro M, Frantz I, Das A, Benitz WE, Shane AL, Higgins R, Stoll BJ Pediatrics 2015 Dec
    Index of Suspicion in the Nursery: Progressive lethargy in a four-day-old term infant
    Weydig HM, Veltkamp D, Kakkilaya V, Stumpf K, Waber LJ, Brion LP NeoReviews 2015 Nov 16 11
    Index of suspicion. Hyperbilirubinemia without jaundice in a neonate
    Sen SK, Mayor R, Engle WD, Blumenschein SD, Brion LP. NeoReviews 2015 Aug 16 8

    Books

    Featured Books Legend Featured Books

    Neonatal jaundice. In McInerny T, Adam HM, Campbell DE, Foy JM, Kamat, DM, DeWitt TG, eds. AAP Textbook of Pediatric Care.

    Kapadia VS, Brion LP. (2015). Elk Grove Village, IL: American Academy of Pediatrics.

    Clinical significance of developmental renal physiology. In Fetal and Neonatal Physiology

    Brion LP, Satlin LM (1998). Philadelphia, PA: Saunders.

    Kidney and Urinary Tract. In Fanaroff AA, Martin RJ, eds. Neonatal-Perinatal Medicine.

    Brion LP, Bernstein J, Spitzer A. (1997). St. Louis, MO: Mosby.

    Renal disease. In Avery's Neonatology: Pathophysiology and Management of the Newborn.

    Nafday S, Brion LP, Benchimol C, Satlin LM, Flynn J, Edelmann CM Jr. (2004). Philadelphia, PA: JB Lippincott Company.

    Renal disease. In MacDonald MG, Mullett MD, Seshia MMK, eds. Avery's Neonatology: Pathophysiology and Management of the Newborn

    Nafday SM, Woda CB, Saland JM, Flynn JT, Askenzi D, Benchimol C, Brion LP. (2015). Philadelphia, PA: JB Lippincott Company.

    Neonatal Jaundice. In Campbell DE, ed. Neonatology for Primary Care.

    Kapadia VS, Brion LP. (2015). Elk Grove Village, IL: American Academy of Pediatrics.

    Neonatal jaundice in the term and near term infant. In TK McInerny, HM Adam, DE Campbell, DM Kamat, KJ Kelleher, eds. American Academy of Pediatrics Textbook of Pediatric Care.

    Brion LP. (2009). Elk Grove Village, IL: American Academy of Pediatrics.

    Renal Disease. In MacDonald MG, ed. Neonatology: Pathophysiology and Management of the Newborn.

    Brion LP, Satlin LM, Edelmann CM Jr. (1999). Philadelphia, PA: JB Lippincott Company.

    Honors & Awards

    • Elected to American Pediatric Society
      (2015)
    • Recognition by program directors for special contribution
      COGME, Albert Einstein College of Medicine, Bronx, NY (2006)
    • Best Doctors in America
      (2003-2014)
    • America's Registry of Outstanding Professionals
      (2002-2003)
    • New York Metro Area Top Doctors
      Castle Connolly Medical Ltd (2001-2005)

    Professional Associations/Affiliations

    • American Pediatric Society (2014)
    • American Academy of Pediatrics
    • American Medical Association
    • Society of Pediatric Research