Biography

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Juan M. Pascual is the inaugural holder of The Once Upon a Time Foundation Professorship in Pediatric Neurologic Diseases. He is a tenured faculty member in four Departments at The University of Texas Southwestern Medical Center at Dallas: Neurology and Neurotherapeutics, Physiology, Pediatrics and the Eugene McDermott Center for Human Growth & Development / Center for Human Genetics, and is Director of the Rare Brain Disorders Program (Clinic and Laboratory). He is also a member of the Division of Pediatric Neurology, of the graduate Ph.D. programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics and Medical Genetics. He also teaches at the UT Southwestern Medical School.

In addition, Dr. Pascual is an adjunct professor in the Department of Biological Sciences at the School of Natural Sciences and Mathematics, The University of Texas at Dallas.

Dr. Pascual directs a highly collaborative research laboratory and is credentialed campus-wide at Children's Medical Center Dallas, UT Southwestern University Hospitals and Clinics and Parkland Memorial Hospital, where he consults on inpatients and outpatients with particularly complex or severe diseases. Much of his research is funded by the National Institutes of Health.

Dr. Pascual received his M.D. degree from the Universidad de Granada, Spain (founded in 1531 by Emperor Charles V). He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas. His postdoctoral research was conducted at the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution under a Neurological Sciences Academic Development Award from the National Institute of Neurological Disorders and Stroke. He also received residency training in Pediatrics at Washington University School of Medicine - St. Louis Children’s Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York - Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.

As one of few actively practising pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases. His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics. The laboratory is home to scientists from very broad backgrounds and levels of training and expertise who have joined efforts to endow both pediatric neurology and human developmental neuroscience with a strong scientific basis.

As a clinician, Dr. Pascual specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in clinical trials. Dr. Pascual has special clinical research expertise in rare diseases, glucose metabolism, mitochondrial, degenerative, and multi-organ disorders. 

Dr. Pascual has co-authored over two dozen scientific, medical and philosophical textbooks. He is the editor, together with Dr. Roger Rosenberg of Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (5th edition, Academic Press, 2015). He is now writing his new textbook Progressive and Degenerative Brain Disorders in Children (Cambridge University Press).

An avid reader, speaker and humanist, Dr. Pascual is also interested in metaphysics and the philosophy of mind. He is particularly concerned with the study of autonomy (both as a predicate of historical significance and as a human developmental phenomenon) and with the definition and appearance of sentience in man. He is a member of the North Texas Bioethics Network, tasked with enhancing community service, promoting public and professional education and increasing collaborative opportunities for research, teaching and contributions to the literature in the field of bioethics.

Dr. Pascual has no interest in -nor is he sponsored by- any business that conducts medical research or lobbies for financial gain.

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Patient referrals to the clinic and location of the research laboratory

Clinical research studies

Publications listed in PubMed (National Library of Medicine)

Education

Medical School Universidad de Granada (1990)
Graduate School Baylor College of Medicine (1995)
Internship Washington University St. Louis (1999), Pediatrics
Residency Columbia Presbyterian Medical Center - NY (2002), Pediatric Neurology

Specialty Areas

Clinical Interest

  • Complex, Rare & Undiagnosed Brain Disorders
  • Mitochondrial Disorders
  • Neurodegenerative Diseases of Children
  • Neurogenetics
  • Neurological and Genetic Disorders

Research Interest

  • 2-hit, multiple-gene and explanatory validity of complex causation models
  • Brain metabolism
  • Clinical trials for neurological and genetic disorders
  • Complex, rare and undiagnosed diseases
  • Final common pathways shared by diseases of neural development
  • Functional brain imaging
  • Human brain development
  • Mitochondrial disorders
  • Neural excitability: synaptic transmission
  • Neurodegenerative diseases of children
  • Neurogenetics
  • Sentience, autonomy and sources of truth
  • Whole exome and genome analyses in neurological disorders

Publications

Featured Publications LegendFeatured Publications

Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism.
Xu F, Liu P, Pascual JM, Xiao G, Huang H, Lu H Hum Brain Mapp 2014 Oct
Diagnostic yield of clinical next-generation sequencing panels for epilepsy.
Wang J, Gotway G, Pascual JM, Park JY JAMA Neurol 2014 May 71 5 650-1
A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Möbius syndrome.
Ali Z, Xing C, Anwar D, Itani K, Weakley D, Gong X, Pascual JM, Mootha VV Mol. Vis. 2014 20 368-75
Alternating Hemiplegia of Childhood With a de Novo Mutation in ATP1A3 and Changes in SLC2A1 Responsive to a Ketogenic Diet.
Ulate-Campos A, Fons C, Artuch R, Castejón E, Martorell L, Ozelius L, Pascual J, Campistol J Pediatr. Neurol. 2013 Dec
Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene.
Chanprasert S, Wang J, Weng SW, Enns GM, Boué DR, Wong BL, Mendell JR, Perry DA, Sahenk Z, Craigen WJ, Alcala FJ, Pascual JM, Melancon S, Zhang VW, Scaglia F, Wong LJ Mol. Genet. Metab. 2013 Jul

Books

Featured Books Legend Featured Books

Floppy infant syndrome. In Merritt's Neurology, 11th and 12th edition

Pascual JM, De Vivo DC (2009). Lippincott, Williams & Wilkins

Pediatric neurology. In On Call Neurology, 2nd and 3rd edition

Pascual JM (2007). W.B. Saunders

Glucose transporter type 1 deficiency syndrome. In Merritt's Neurology, 11th and 12th edition

De Vivo DC, Pascual JM, Wang D (2009). Lippincott, Williams & Wilkins

Disorders of glucose transport. In The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3rd and 4th editions

De Vivo DC, Wang D, Pascual JM (2008). LWW

Developmental Neurology: a molecular perspective. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Metabolic diseases of the nervous system. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Genetic disorders of neuromuscular development. In Molecular Neurology, 1st edition

Pascual JM (2007). Academic Press

Encephalopathies. In Neurology and Clinical Neuroscience, 1st edition

Pascual JM (2007). Mosby Elsevier

Glucose transporter 1 deficiency syndrome. In National Organization for Rare Disorders' Guide to Rare Disorders

Pascual JM, K. Engelstad, D. Wang, D. C. De Vivo (2002). Lippincott, Williams, and Wilkins

Kernicterus. In Encyclopedia of the Neurological Sciences, 2nd edition

Pascual JM (2014). San Diego, Academic Press

The Can't and Don't of Psychopathy: Neuroimaging Technologies, Psychopaths and Criminal Responsibility. In Neuroethics: Issues at the Intersection of Neuroscience and Society

Jotterand F, Pascual JM, Sadler, JZ (In press). Cambridge University Press

Disorders of Muscle Excitability. In Basic Neurochemistry, 7th and 8th edition

Pascual JM (2011). Elsevier

Disorders of the Krebs cycle and of pyruvate metabolism and transport. In Rudolph's Pediatrics, 22nd edition

Pascual JM, DiMauro S (2011). McGraw-Hill

Pyruvate dehydrogenase, pyruvate carboxylase, Krebs cycle and mitochondrial transport disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Tondo, M; Marin-Valencia, I; Ma, Q; Pascual, JM (2015). San Diego, Academic Press

Menkes disease and other ATP7A disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Pascual, JM; Menkes, JH (2015). San Diego, Academic Press

Wolman disease. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Marin-Valencia, I; Pascual, JM (2015). San Diego, Academic Press

Glucose transporter type I haploinsufficiency. In Movement Disorders, 2nd edition: Genetics and Models

Pascual JM (2014). San Diego, Academic Press

Glucose transporter type I deficiency and other glucose flux disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

Pascual, JM; Wang, D; De Vivo, DC (2015). San Diego, Academic Press

Honors & Awards

  • 100% Patient satisfaction
    Division of Pediatric Neurology, Children's Medical Center Dallas (2013)
  • Elected full member
    Académie Européenne des Sciences, des Arts et des Lettres (2013)
  • Research Mentor Award
    Children's Medical Center Dallas (2012)
  • Elected corresponding member
    Académie Européenne des Sciences, des Arts et des Lettres (2010)
  • Miembro correspondiente
    Real Academia de Bellas Artes de San Telmo (2010)
  • Young Investigator Award
    Neurobiology of Disease in Children (2009)
  • Miembro correspondiente
    Real Academia Española (2004)
  • Miembro de número
    Academia Norteamericana de la Lengua Española (2004)

Professional Associations/Affiliations

  • Children's Medical Center Dallas (2007)
  • Parkland Memorial Hospital (2007)
  • UT Southwestern Medical Center Hospitals and Clinics (2007)