Juan Pascual, M.D., Ph.D.
Assistant Professor
Department: Neurology & Neurotherapeutics, Pediatrics
Graduate Programs: Integrative Biology, Neuroscience
Biography
Juan M. Pascual holds appointments to the faculty of the Departments of Neurology and Neurotherapeutics, Physiology and Pediatrics and is Director of the Rare Brain Disorders Clinic and Laboratory. He is also a member of the Division of Pediatric Neurology, of the graduate programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics and Medical Genetics.
Dr. Pascual directs a vibrant research laboratory in molecular neurobiology while also caring for children and adults, and is credentialed campus-wide at Children's Medical Center Dallas, UT Southwestern University Hospitals and Clinics and Parkland Memorial Hospital, where he consults on inpatients and outpatients with undiagnosed or unusual disorders.
Dr. Pascual received his M.D. degree from the Universidad de Granada, Spain (founded in 1526 by Emperor Charles V over the school established by the Nasrid Sultan of Granada in 1349). He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas. His postdoctoral research was conducted at the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and, later, at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution under a Neurological Sciences Academic Development Award from the National Institute of Neurological Disorders and Stroke. He also obtained residency training in Pediatrics at Washington University School of Medicine- St. Louis Children’s Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York- Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.
As a clinician, he specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in pilot and national clinical trials. Dr. Pascual has special clinical research expertise in glucose metabolism, mitochondrial and unusual degenerative and multi-organ disorders.
As one of few pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases. His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics.
An avid reader, speaker and humanist, Dr. Pascual is also interested in metaphysics, epistemology and the philosophy of mind.
Education
| Medical School | Universidad de Granada (1990) |
| Graduate School | Baylor College of Medicine (1995) |
| Internship | Washington University St. Louis (1999), Pediatrics |
| Residency | Columbia Presbyterian Medical Center - NY (2002), Pediatric Neurology |
Specialty Areas
Clinical Interests
- Primary Interests
- Complex, Rare and Undiagnosed Brain Disorders
- Mitochrondrial Disorders
- Neurodegenerative Diseases of Children
- Neurogenetics
- Neurological and Genetic Disorders
Research Interests
- Brain metabolism
- Clinical trials for neurological and genetic disorders
- Complex, rare and undiagnosed diseases
- Functional brain imaging
- Human brain development
- Mitochondrial disorders
- Neural excitability: synaptic transmission
- Neurodegenerative diseases of children
- Neurogenetics
- Sentience, autonomy and sources of truth
Publications
Featured Publications
Marin-Valencia I, Good LB, Ma Q, Malloy CR, Pascual JM J. Cereb. Blood Flow Metab. 2012 Oct
Marin-Valencia I, Good LB, Ma Q, Malloy CR, Patel MS, Pascual JM Neurochem. Int. 2012 Aug
Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM Cell Metab. 2012 Jun 15 6 827-37
Marin-Valencia I, Good LB, Ma Q, Duarte J, Bottiglieri T, Sinton CM, Heilig CW, Pascual JM Neurobiology of disease 2012 Apr
Choi C, Ganji SK, Deberardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang XL, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CM, Bachoo RM, Maher EA Nature medicine 2012 Jan
Animal models of the human mind: Is there anything it is like to be autistic?
Pascual JM Neuroscience letters 2011 Oct
Marin-Valencia I, Good LB, Ma Q, Jeffrey FM, Malloy CR, Pascual JM Journal of neuroscience methods 2011 Sep
Pascual JM, Roe CR JAMA Neurol 2013 Apr 1-8
Modeling of brain metabolism and pyruvate compartmentation using 13C NMR in vivo: caution required
Jeffrey FM, Marin-Valencia I, Good LB, Shestov AA, Henry PG, Pascual JM, Malloy CR J Cereb Blood Flow Metab 2013 May 8. doi: 10.1038/jcbfm.2013.67. [Epub ahead of print]
Atlas of Inherited Metabolic Diseases, 3rd ed.
Pascual JM Arch. Neurol. 2012 Nov 69 11 1521-2
Books
Featured Books
The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 5th edition
Pascual, JM, Rosenberg, RN (Ed.) (In preparation). Elsevier (Academic Press)
Floppy infant syndrome. In Merritt's Neurology, 11th and 12th edition
Pascual JM, De Vivo DC (2009). Lippincott, Williams & Wilkins
Pediatric neurology. In On Call Neurology, 2nd and 3rd edition
Pascual JM (2007). W.B. Saunders
Glucose transporter type 1 deficiency syndrome. In Merritt's Neurology, 11th and 12th edition
De Vivo DC, Pascual JM, Wang D (2009). Lippincott, Williams & Wilkins
Disorders of glucose transport. In The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3rd and 4th editions
De Vivo DC, Wang D, Pascual JM (2008). LWW
Developmental Neurology: a molecular perspective. In Molecular Neurology, 1st edition
Pascual JM (2007). Academic Press
Metabolic diseases of the nervous system. In Molecular Neurology, 1st edition
Pascual JM (2007). Academic Press
Genetic disorders of neuromuscular development. In Molecular Neurology, 1st edition
Pascual JM (2007). Academic Press
Encephalopathies. In Neurology and Clinical Neuroscience, 1st edition
Pascual JM (2007). Mosby Elsevier
Glucose transporter 1 deficiency syndrome. In National Organization for Rare Disorders' Guide to Rare Disorders
Pascual JM, K. Engelstad, D. Wang, D. C. De Vivo (2002). Lippincott, Williams, and Wilkins
Kernicterus. In Encyclopedia of Neurological Sciences, 2nd edition
Pascual JM (In press).
The Can't and Don't of Psychopathy: Neuroimaging Technologies, Psychopaths and Criminal Responsibility. In Neuroethics: Issues at the Intersection of Neuroscience and Society
Jotterand F, Pascual JM, Sadler, JZ (In press). Cambridge University Press
Disorders of Muscle Excitability. In Basic Neurochemistry, 7th and 8th edition
Pascual JM (2011). Elsevier
Disorders of the Krebs cycle and of pyruvate metabolism and transport. In Rudolph's Pediatrics, 22nd edition
Pascual JM, DiMauro S (2011). McGraw-Hill
Honors/Awards
- Research Mentor Award
Children's Medical Center Dallas (2012) - Elected member
Académie Européenne des Sciences, des Arts et des Lettres (2010) - Miembro correspondiente
Real Academia de Bellas Artes de San Telmo (2010) - Young Investigator Award
Neurobiology of Disease in Children (2009) - Miembro correspondiente
Real Academia Española (2004) - Miembro de número
Academia Norteamericana de la Lengua Española (2004)