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Juan M. Pascual is the inaugural holder of The Once Upon a Time Foundation Professorship in Pediatric Neurologic Diseases. He is a tenured faculty member in four Departments at The University of Texas Southwestern Medical Center at Dallas: Neurology and Neurotherapeutics, Physiology, Pediatrics and the Eugene McDermott Center for Human Growth & Development / Center for Human Genetics, and is Director of the Rare Brain Disorders Program (Clinic and Laboratory). He is also a member of the Division of Pediatric Neurology, of the graduate Ph.D. programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics and Medical Genetics. He also teaches at the UT Southwestern Medical School.

In addition, Dr. Pascual is an adjunct professor in the Department of Biological Sciences at the School of Natural Sciences and Mathematics, The University of Texas at Dallas.

Dr. Pascual directs a highly collaborative research laboratory and is credentialed campus-wide at Children's Medical Center Dallas, UT Southwestern University Hospitals and Clinics and Parkland Memorial Hospital, where he consults on inpatients and outpatients with particularly complex or severe diseases. Much of his research is funded by the National Institutes of Health.

Dr. Pascual received his M.D. degree from the Universidad de Granada, Spain (founded in 1531 by Emperor Charles V). He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas, under Arthur M. Brown, MD, PhD, McCollum Professor and Chair. His postdoctoral research was conducted under Arthur Karlin, PhD, Higgins Professor and Director of the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and, later, at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution under a Neurological Sciences Academic Development Award from the National Institute of Neurological Disorders and Stroke. He also received residency training in Pediatrics at Washington University School of Medicine - St. Louis Children’s Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York - Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.

As one of few actively practising pediatric neurologists in the nation who is also a laboratory scientist, Dr. Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance (MRI) both in human subjects and in models of human diseases. His laboratory is located in the newest biomedical research building (NL) at UT Southwestern and is an integral part of the Department of Neurology and Neurotherapeutics. The laboratory is home to scientists from very broad backgrounds and levels of training and expertise who have joined efforts to endow both pediatric neurology and human developmental neuroscience with a strong scientific basis.

As a clinician, Dr. Pascual specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in clinical trials. Dr. Pascual has special clinical research expertise in rare diseases, glucose metabolism, mitochondrial, degenerative, and multi-organ disorders. 

Dr. Pascual has co-authored over two dozen scientific, medical and philosophical textbooks. He is the editor, together with Dr. Roger Rosenberg of Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease (5th edition, Academic Press, 2015). He is now writing his new textbook Progressive and Degenerative Brain Disorders in Children (Cambridge University Press).

An avid reader, speaker and humanist, Dr. Pascual is also interested in metaphysics and the philosophy of mind. He is particularly concerned with the study of autonomy (both as a predicate of historical significance and as a human developmental phenomenon) and with the definition and appearance of sentience in man. He is a member of the North Texas Bioethics Network, tasked with enhancing community service, promoting public and professional education and increasing collaborative opportunities for research, teaching and contributions to the literature in the field of bioethics.

Dr. Pascual has no interest in -nor is he sponsored by- any business that conducts medical research or lobbies for financial gain.

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Patient referrals to the clinic and location of the research laboratory

Clinical research studies

Publications listed in PubMed (National Library of Medicine)


Medical School
Universidad de Granada (1990)
Graduate School
Baylor College of Medicine (1995)
Washington University St. Louis (1999), Pediatrics
Columbia Presbyterian Medical Center - NY (2002), Pediatric Neurology

Specialty Areas

Clinical Interest

  • Complex, Rare & Undiagnosed Brain Disorders
  • Mitochondrial Disorders
  • Neurodegenerative Diseases of Children
  • Neurogenetics
  • Neurological and Genetic Disorders
  • Research Interest

    • 2-hit, multiple-gene and explanatory validity of complex causation models
    • Brain metabolism
    • Clinical trials for neurological and genetic disorders
    • Complex, rare and undiagnosed diseases
    • Final common pathways shared by diseases of neural development
    • Functional brain imaging
    • Human brain development
    • Mitochondrial disorders
    • Neural excitability: synaptic transmission
    • Neurodegenerative diseases of children
    • Neurogenetics
    • Sentience, autonomy and sources of truth
    • Whole exome and genome analyses in neurological disorders


    Featured Publications LegendFeatured Publications

    A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
    Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 May
    Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
    Rajagopalan KN, Egnatchik RA, Calvaruso MA, Wasti AT, Padanad MS, Boroughs LK, Ko B, Hensley CT, Acar M, Hu Z, Jiang L, Pascual JM, Scaglioni PP, DeBerardinis RJ Cancer Metab 2015 3 7
    Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism.
    Xu F, Liu P, Pascual JM, Xiao G, Huang H, Lu H Hum Brain Mapp 2014 Oct
    Diagnostic yield of clinical next-generation sequencing panels for epilepsy.
    Wang J, Gotway G, Pascual JM, Park JY JAMA Neurol 2014 May 71 5 650-1


    Featured Books Legend Featured Books

    Floppy infant syndrome. In Merritt's Neurology, 11th and 12th edition

    Pascual JM, De Vivo DC (2009). Lippincott, Williams & Wilkins

    Pediatric neurology. In On Call Neurology, 2nd and 3rd edition

    Pascual JM (2007). W.B. Saunders

    Glucose transporter type 1 deficiency syndrome. In Merritt's Neurology, 11th and 12th edition

    De Vivo DC, Pascual JM, Wang D (2009). Lippincott, Williams & Wilkins

    Disorders of glucose transport. In The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, 3rd and 4th editions

    De Vivo DC, Wang D, Pascual JM (2008). LWW

    Developmental Neurology: a molecular perspective. In Molecular Neurology, 1st edition

    Pascual JM (2007). Academic Press

    Metabolic diseases of the nervous system. In Molecular Neurology, 1st edition

    Pascual JM (2007). Academic Press

    Genetic disorders of neuromuscular development. In Molecular Neurology, 1st edition

    Pascual JM (2007). Academic Press

    Encephalopathies. In Neurology and Clinical Neuroscience, 1st edition

    Pascual JM (2007). Mosby Elsevier

    Glucose transporter 1 deficiency syndrome. In National Organization for Rare Disorders' Guide to Rare Disorders

    Pascual JM, K. Engelstad, D. Wang, D. C. De Vivo (2002). Lippincott, Williams, and Wilkins

    Kernicterus. In Encyclopedia of the Neurological Sciences, 2nd edition

    Pascual JM (2014). San Diego, Academic Press

    The Can't and Don't of Psychopathy: Neuroimaging Technologies, Psychopaths and Criminal Responsibility. In Neuroethics: Issues at the Intersection of Neuroscience and Society

    Jotterand F, Pascual JM, Sadler, JZ (In press). Cambridge University Press

    Disorders of Muscle Excitability. In Basic Neurochemistry, 7th and 8th edition

    Pascual JM (2011). Elsevier

    Disorders of the Krebs cycle and of pyruvate metabolism and transport. In Rudolph's Pediatrics, 22nd edition

    Pascual JM, DiMauro S (2011). McGraw-Hill

    Pyruvate dehydrogenase, pyruvate carboxylase, Krebs cycle and mitochondrial transport disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

    Tondo, M; Marin-Valencia, I; Ma, Q; Pascual, JM (2015). San Diego, Academic Press

    Menkes disease and other ATP7A disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

    Pascual, JM; Menkes, JH (2015). San Diego, Academic Press

    Wolman disease. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

    Marin-Valencia, I; Pascual, JM (2015). San Diego, Academic Press

    Glucose transporter type I haploinsufficiency. In Movement Disorders, 2nd edition: Genetics and Models

    Pascual JM (2014). San Diego, Academic Press

    Glucose transporter type I deficiency and other glucose flux disorders. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Fifth Edition

    Pascual, JM; Wang, D; De Vivo, DC (2015). San Diego, Academic Press

    Honors & Awards

    • 100% Patient satisfaction
      Division of Pediatric Neurology, Children's Medical Center Dallas (2013)
    • Elected full member
      Académie Européenne des Sciences, des Arts et des Lettres (2013)
    • Research Mentor Award
      Children's Medical Center Dallas (2012)
    • Elected corresponding member
      Académie Européenne des Sciences, des Arts et des Lettres (2010)
    • Miembro correspondiente
      Real Academia de Bellas Artes de San Telmo (2010)
    • Young Investigator Award
      Neurobiology of Disease in Children (2009)
    • Miembro correspondiente
      Real Academia Española (2004)
    • Miembro de número
      Academia Norteamericana de la Lengua Española (2004)

    Professional Associations/Affiliations

    • Children's Medical Center Dallas (2007)
    • Parkland Memorial Hospital (2007)
    • UT Southwestern Medical Center Hospitals and Clinics (2007)