Caroline Smith, M.D. Titles and Appointments Assistant Professor Schools Medical School Departments Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Dr. Caroline Smith joined UT Southwestern as an Instructor in the Department of Pediatrics in the Division of Hematology and Oncology in 2023. Dr. Smith earned her undergraduate degree in Human Biology with a minor in American Studies at Stanford University. She completed her medical degree at UT Southwestern and her residency training in Pediatrics at Boston Children’s Hospital and Boston Medical Center in the Boston Combined Residency Program (BCRP). Ultimately, she returned to UT Southwestern / Children’s Medical Center Dallas for her fellowship training in Pediatric Hematology and Oncology. Dr. Smith’s clinical and research interests include leukemia and lymphoma, in particular, studying the role of novel targeted cancer therapeutics in patients with relapsed or refractory leukemia. Dr. Smith conducts her research in the Alec Zhang Lab under the co-mentorship of Dr. Samuel John, studying the role of the tumor microenvironment and a novel CAR-T cell therapy in infant leukemia and other leukemias with KMT2A rearrangements. Education Medical School UT Southwestern Medical School (2017) Residency Boston Children's Hospital (2020), Pediatrics Fellowship UT Southwestern Medical Center (2023), Pediatric Hematology/oncology Research Interest Acute Lymphoblastic Leukemia (ALL) Acute Myeloid Leukemia (AML) Cellular & Targeted Therapies Infant Leukemia Lymphoma Relapsed and Refractory Leukemia Publications Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia Smith CC, Tasian SK Current Opinion in Pharmacology 2025 Aug 83 Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development He Y, Zhang C, Tan L, Deng M, Liu X, Huang R, Yang X, Xie J, Lou Q, Fang M, Smith C, John S, Xiong W, Li X, Lewis C, Homsi J, Gupta A, Zhang N, An Z, Zhang CC Cancer Immunology Research 2025 Jun 13 821-835 Higher Rates of Hypersensitivity Reactions to Calaspargase Compared With Pegaspargase: A Single Center Retrospective Review McCarty K, Smith C, Zhang S, Gao A, Patel B, Cox J, Winick N, Slone T Pediatric Blood and Cancer 2025 May 72 Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ Nature Nanotechnology 2024 Sep 19 1409-1417 Anaplastic sarcoma of the kidney (DICER1-sarcoma of the kidney): A report from the International Pleuropulmonary Blastoma/DICER1 Registry Schoettler PJ, Smith CC, Nishitani M, Harris AK, Nelson AT, Watson DA, Kamihara J, Mullen EA, Hill DA, Messinger YH, Fair DB, Kumar KA, Dehner LP, Ash S, Chen KS, Schultz KA Pediatric Blood and Cancer 2024 Aug 71 LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development Huang R, Liu X, Kim J, Deng H, Deng M, Gui X, Chen H, Wu G, Xiong W, Xie J, Lewis C, Homsi J, Yang X, Zhang C, He Y, Lou Q, Smith C, John S, Zhang N, An Z, Zhang CC Cancer Immunology Research 2024 Mar 12 350-362 Metachronous diagnosis of synovial sarcoma and papillary thyroid carcinoma in a child Yang AT, Smith C, Callan A, Liu C, Stewart R, Sengupta A, Leavey PJ Pediatric Blood and Cancer 2022 Jan 69 The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial Fowler C, Wu UI, Shaffer R, Smith C, Barnhart L, Bryant C, Olivier K, Holland SM BMJ Open Respiratory Research 2020 Mar 7 A familial syndrome of pulmonary nontuberculous mycobacteria infections Leung JM, Fowler C, Smith C, Adjemian J, Frein C, Claypool RJ, Holland SM, Prevots RD, Olivier K American Journal of Respiratory and Critical Care Medicine 2013 Dec 188 1373-1376 Abnormal nasal nitric oxide production, ciliary beat frequency, and toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium Fowler CJ, Olivier KN, Leung JM, Smith CC, Huth AG, Root H, Kuhns DB, Logun C, Zelazny A, Frein CA, Daub J, Haney C, Shelhamer JH, Bryant CE, Holland SM American Journal of Respiratory and Critical Care Medicine 2013 Jun 187 1374-1381 Results 1-10 of 10 1 Honors & Awards Alpha Omega Alpha (AOA) (2017) Kurt Ian Wey Senior Pediatrics AwardTop medical student entering pediatrics (2017) Professional Associations/Affiliations Alpha Omega Alpha (AOA) (2017) American Academy of Pediatrics (AAP) (2017) American Society of Clinical Oncology (ASCO) (2020) American Society of Hematology (ASH) (2020) American Society of Pediatric Hematology/Oncology (ASPHO) (2020) Children's Oncology Group (COG) (2020)
