Biography

Dr. Chang received her Ph.D. in Molecular and Cellular Pharmacology at University of Miami School of Medicine in Miami, Florida. She obtained her postdoctoral training in the Department of Physiology at UTSW, and moved up the ranks to Assistant Professor in Internal Medicine, Division of Nephrology and Center for Mineral Metabolism. Dr. Chang has had a longstanding interest in utilizing multi-faceted approaches to identify and characterize physiological and pathophysiological signaling mechanisms that affect muscle contractility. She is currently focused on understanding 1) signaling mechanisms that maintain constitutive cardiac myosin phosphorylation at levels necessary for normal cardiac performance, and 2) how aberrant extracellular signals are transmitted to affect basal myosin phosphorylation levels in vivo in patients with chronic kidney disease. 

Education

Undergraduate
Hawaii Pacific University (2001)
Graduate School
University of Miami (2007)

Research Interest

  • Kinases and Phosphatases that Regulate Muscle Function
  • Mechano-signal Transduction and Cell Structure

Publications

Featured Publications LegendFeatured Publications

Physiological versus pharmacological signalling to myosin phosphorylation in airway smooth muscle.
Gao N, Tsai MH, Chang AN, He W, Chen CP, Zhu M, Kamm KE, Stull JT J. Physiol. (Lond.) 2017 Jul
Vascular disease-causing mutation, smooth muscle a-actin R258C, dominantly suppresses functions of a-actin in human patient fibroblasts.
Liu Z, Chang AN, Grinnell F, Trybus KM, Milewicz DM, Stull JT, Kamm KE Proc. Natl. Acad. Sci. U.S.A. 2017 Jun
Role of myosin light chain phosphatase in cardiac physiology and pathophysiology.
Chang AN, Kamm KE, Stull JT J. Mol. Cell. Cardiol. 2016 Oct
Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.
Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT Proc. Natl. Acad. Sci. U.S.A. 2016 Jun
Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle.
Gao N, Chang AN, He W, Chen CP, Qiao YN, Zhu M, Kamm KE, Stull JT J. Physiol. (Lond.) 2016 Feb
Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in vivo.
Chang AN, Battiprolu PK, Cowley PM, Chen G, Gerard RD, Pinto JR, Hill JA, Baker AJ, Kamm KE, Stull JT J. Biol. Chem. 2015 Mar
Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle.
Tsai MH, Chang AN, Huang J, He W, Sweeney HL, Zhu M, Kamm KE, Stull JT J. Physiol. (Lond.) 2014 May
The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts.
Chang AN, Huang J, Battiprolu PK, Hill JA, Kamm KE, Stull JT PLoS ONE 2013 8 6 e66720
Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK).
Chang AN, Chen G, Gerard RD, Kamm KE, Stull JT J. Biol. Chem. 2010 Feb 285 8 5122-6

Honors & Awards

  • Scientist Development Grant
    American Heart Association (2017)
  • Postdoctoral Fellowship Award
    American Heart Associate (2009)
  • Predoctoral Fellowship Award
    American Heart Association (2004)

Professional Associations/Affiliations

  • American Heart Association (2015)
  • Biophysical Society (2005)