Hanzhang Lu, Ph.D.

Dr. Lu received his Bachelor’s degree from Shanghai Jiao Tong University in China in 1996. He then came to the U.S. and received a Master's and PhD degree in 1999 and 2004, respectively, both from Johns Hopkins University. Dr. Lu’s research focuses on the development of MRI techniques to evaluate vascular physiology in the brain (such as blood flow, blood volume, blood oxygenation, and oxygen consumption) and on the application of these techniques to understand brain function and dysfunction in brain disorders (e.g. Alzheimer’s Disease, Brain tumor, and Multiple Sclerosis). He has previously pioneered a number of MRI techniques, including Vascular-Space-Occupancy (VASO) fMRI for mapping brain activity using CBV-based mechanism, Multiple-Acquisitions-with-Global-Inversion-Cycling (MAGIC) for maintaining nulling conditions of multiple slices, and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI to estimate brain oxygen saturation. Dr. Lu also has extensive experience on Arterial-Spin-Labeling (ASL) MRI for the measurement of cerebral perfusion.

Dr. Lu joined UT Southwestern in 2005 as an Assistant Professor and was promoted to Associate Professor with tenure in 2010. He is also the chief neuroimaging scientist at the Advanced Imaging Research Center, and has been responsible for setting up and overseeing the neuroimaging facility at the Center.

Undergraduate	Shanghai Jiao Tong University (), Biomedical Engineering
Graduate School	Johns Hopkins University (2004)

• Cerebrovascular physiology
• Diffusion MRI
• Functional magnetic resonance imaging (fMRI)
• MR physics and pulse sequence design
• Perfusion MRI

Featured Publications

Novel Approach to Measure Absolute Cerebral Blood Volume using Vascular-Space-Occupancy (VASO) Dependent MRI.

Lu, H., Law, M., Johnson, G., Ge, Y., van Zijl, P.C., and Helpern, J.A. Magnetic Resonance in Medicine 2005 54 1403-1411

Routine Clinical Brain MRI Sequences for Use at 3.0 Tesla.

Lu, H., Nagae-Poetscher, L.M., Golay, X., Lin D., Pomper M.G., and van Zijl, P.C. Journal of Magnetic Resonance Imaging 2005 22 13-22

Sustained post-stimulus elevation in cerebral oxygen utilization following vascular recovery.

Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Journal of Cerebral Blood Flow and Metabolism 2004 24 764-770

Functional Magnetic Resonance Imaging Based on Changes in Vascular Space Occupancy.

Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Magnetic Resonance in Medicine 2003 50 263-274

Novel Approach to Measure Absolute Cerebral Blood Volume using Vascular-Space-Occupancy (VASO) Dependent MRI.

Lu, H., Law, M., Johnson, G., Ge, Y., van Zijl, P.C., and Helpern, J.A. Magnetic Resonance in Medicine December 2005 54 1403-1411

Retinotopic mapping in human visual cortex using Vascular-Space-Occupancy (VASO) dependent fMRI.

Lu, H., Basso, G., Serences, J.T., Yantis, S., Golay, X., and van Zijl, P.C. NeuroReport October 2005 16 1635-1640

Routine Clinical Brain MRI Sequences for Use at 3.0 Tesla.

Lu, H., Nagae-Poetscher, L.M., Golay, X., Lin D., Pomper M.G., and van Zijl, P.C. Journal of Magnetic Resonance Imaging July 2005 22 13-22

Experimental Separation of Intra and Extravascular BOLD Effects using Multi-echo VASO and BOLD fMRI at 1.5T and 3.0T.

Lu, H., and van Zijl, P.C. Magnetic Resonance in Medicine April 2005 53 808-816

• Alzheimer’s Association Award
  (2006)
• TI Endowed Scholar in Advanced Imaging Technologies
  (2005)
• Phi Beta Kappa
  (2004)
• Young Investigator Award
  Gordon Research Conference on Brain Energy Metabolism and Blood Flow (2004)
• Suraj Manrao Award
  Experimental NMR Conference (2003)