Featured Publications
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
Lei Wang, Jianjun Chang, Diana Varghese, Michael Dellinger, Subodh Kumar, Anne M. Best, Julio Ruiz, Richard Bruick, Samuel Pena-LLopis, Junjie Xu, David J. Babinski, Doug E. Frantz, Rolf A. Brekken, Amy M. Quinn, Anton Simeonov, Johnny Easmon and Elisabeth D. Martinez Nat Commun. 2013 2035 4
Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide.
Chang J, Varghese DS, Gillam MC, Peyton M, Modi B, Schiltz RL, Girard L, Martinez ED Br. J. Cancer 2012 Jan 106 1 116-25
Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.
Best AM, Chang J, Dull AB, Beutler JA, Martinez ED J. Biomed. Biotechnol. 2011 2011 868095
Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.
Holbeck S, Chang J, Best AM, Bookout AL, Mangelsdorf DJ, Martinez ED Mol. Endocrinol. 2010 Jun 24 6 1287-96
Characterizing heterogeneous cellular responses to perturbations.
Slack MD, Martinez ED, Wu LF, Altschuler SJ Proc. Natl. Acad. Sci. U.S.A. 2008 Dec 105 49 19306-11
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED Anal. Biochem. 2008 Apr 375 2 237-48
Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition.
Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O EMBO Rep. 2007 Nov 8 11 977-81
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H, Adkins NL, Stavreva DA, Wiench M, Georgel PT, Schiltz RL, Hager GL Mol. Cell 2006 Jun 22 5 669-79
Loss of androgen receptor transcriptional activity at the G(1)/S transition.
Martinez ED, Danielsen M J. Biol. Chem. 2002 Aug 277 33 29719-29
The Nuclear Receptor Resource: a growing family
Martinez, E., Moore, D., Keller, E., Pearce, D., Vanden Heuvel, J.P., Robinson, V., Gottlieb, B., McDonald, P., Simons, S., Sanchez, E. and Danielsen, M. Nucleic Acids Res 1998 26 239-241
