Dr. Angela Scheuerle fell in love with genetics as a sophomore in high school and never looked back. She now has the career that she wanted at the age of 15 – even though such a profession didn’t exist at the time. Learning the intricacies of the science is like learning the secret of a magic trick. Remember the “ah hah!” moment when you suddenly mastered a two-wheeler? Genetics is like that.
Dr. Scheuerle graduated Magna Cum Laude as a biology major from Sewanee: The University of the South. She received her M.D. from The University of South Florida Morsani College of Medicine. Dr. Scheuerle completed a Pediatric Residency at Children’s Hospital Medical Center in Cincinnati, Ohio, and Medical Genetics Fellowship at Baylor College of Medicine. Her fellowship started just at the beginning of the Human Genome Project, so she got to “grow up” in genetics at a very exciting time: when it was possible to keep up with gene discoveries because it was about one every two weeks. She has also completed a fellowship in Clinical Ethics at the University of Chicago. Dr. Scheuerle is board certified in Clinical Genetics, Clinical Molecular Genetics, and Pediatrics.
She started shadowing in a craniofacial clinic during high school, where she developed a specific interest in craniofacial malformations. She has practiced Clinical Genetics in Houston and then Dallas since 1995. From 2003 to 2014 she was in private practice at Tesserae Genetics at Medical City Dallas. She has been adjunct faculty at UT Southwestern in the Program of Ethics in Science and Medicine and the McDermott Center for Human Development since 2000. She joined the Pediatric Division of Genetics and Metabolism as full faculty in September 2014.
In addition to clinical practice, Dr. Scheuerle does extensive work in public health and drug safety. She has worked with the Texas Department of State Health Services Birth Defects Epidemiology and Surveillance Branch since 1994. This Branch operates the Texas Birth Defect Registry, an active state surveillance system that monitors birth prevalence of congenital anomalies and genetic conditions. This has become particularly important in 2016 with the Zika virus epidemic. She is part of the birth defect surveillance group monitoring for Zika-related birth defects. In July 2016, she attended and participated in a workshop at the Centers for Disease Control and Prevention to define guidelines for evaluation and management of infants and children exposed to Zika virus.
The Birth Defects Epidemiology and Surveillance Branch also manages the Texas Center for Birth Defects Research and Prevention (TCBDRP), which performs and supports investigation into causes of birth defects. The TCBDRP participated in the 15-year, 10-state National Birth Defects Prevention Study, and Dr. Scheuerle served as the Geneticist for Texas’ contribution to that Study. She continues her involvement with research generated from both the state and national programs.
In 1997, Dr. Scheuerle joined the Antiretroviral Pregnancy Registry (APR). This is an FDA-mandated, post-marketing exposure registry that began in 1989 as the Zidovudine in Pregnancy Registry. This multi-drug registry is one of the largest of its kind, monitoring pregnancy exposure of now over 40 HIV and Hepatitis medications. Dr. Scheuerle’s role as teratologist is to identify those cases in which exposure to one or more medications temporally associates with embryopathogenesis of the anomaly. She also serves on the scientific advisory and steering committees for the APR. Her Organ System Classification schema for categorizing birth defects is one of two recommended by the FDA for use in pharmaceutical pregnancy registry work. Dr. Scheuerle now participates in other pregnancy registries and provides similar consultative services to US- and European-based pharmaceutical companies.
- Medical School
- University of South Florida Morsani College of Medicine (1988)
- University of Cincinnati/Children's Hospital Medical Center (1991), Pediatrics
- Baylor College of Medicine/Texas Children's Hospital (1995), Medical Genetics
- Public health genetics and birth defect surveillance
- Syndrome definition
- Teratogenic risks of prescription medication/drug safety
- Population-based birth defects data in the United States, 2008 to 2012: Presentation of state-specific data and descriptive brief on variability of prevalence.
- Mai CT, Isenburg J, Langlois PH, Alverson CJ, Gilboa SM, Rickard R, Canfield MA, Anjohrin SB, Lupo PJ, Jackson DR, Stallings EB, Scheuerle AE, Kirby RS Birth Defects Res. Part A Clin. Mol. Teratol. 2015 Nov 103 11 972-93
- Prenatal exposure to zidovudine and risk for ventricular septal defects and congenital heart defects: data from the Antiretroviral Pregnancy Registry.
- Vannappagari V, Albano JD, Koram N, Tilson H, Scheuerle AE, Napier MD Eur. J. Obstet. Gynecol. Reprod. Biol. 2015 Nov 197 6-10
- Mandibulofacial Dysostosis with Microcephaly: Mutation and Database Update.
- Huang L, Vanstone MR, Hartley T, Osmond M, Barrowman N, Allanson J, Baker L, Dabir TA, Dipple KM, Dobyns WB, Estrella J, Faghfoury H, Favaro FP, Goel H, Gregersen PA, Gripp KW, Grix A, Guion-Almeida ML, Harr MH, Hudson C, Hunter AG, Johnson J, Joss SK, Kimball A, Kini U, Kline AD, Lauzon J, Lildballe DL, López-González V, Martinezmoles J, Meldrum C, Mirzaa GM, Morel CF, Morton JE, Pyle LC, Quintero-Rivera F, Richer J, Scheuerle AE, Schönewolf-Greulich B, Shears DJ, Silver J, Smith AC, Temple IK, van de Kamp JM, van Dijk FS, Vandersteen AM, White SM, Zackai EH, Zou R, Consortium CC, Bulman DE, Boycott KM, Lines MA Hum. Mutat. 2015 Oct
- Expanding the Molecular and Clinical Phenotype of SSR4-CDG.
- Ng BG, Raymond K, Kircher M, Buckingham KJ, Wood T, Shendure J, Nickerson DA, Bamshad MJ, Wong JT, Monteiro FP, Graham BH, Jackson S, Sparkes R, Scheuerle AE, Cathey S, Kok F, Gibson JB, Freeze HH Hum. Mutat. 2015 Aug
- Descriptive epidemiology of birth defects thought to arise by new mutation.
- Langlois PH, Scheuerle AE Birth Defects Res. Part A Clin. Mol. Teratol. 2015 Jul
- High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation.
- Rojnueangnit K, Xie J, Gomes A, Sharp A, Callens T, Chen Y, Liu Y, Cochran M, Abbott MA, Atkin J, Babovic-Vuksanovic D, Barnett CP, Crenshaw M, Bartholomew DW, Basel L, Bellus G, Ben-Shachar S, Bialer MG, Bick D, Blumberg B, Cortes F, David KL, Destree A, Duat-Rodriguez A, Earl D, Escobar L, Eswara M, Ezquieta B, Frayling IM, Frydman M, Gardner K, Gripp KW, Hernández-Chico C, Heyrman K, Ibrahim J, Janssens S, Keena BA, Llano-Rivas I, Leppig K, McDonald M, Misra VK, Mulbury J, Narayanan V, Orenstein N, Galvin-Parton P, Pedro H, Pivnick EK, Powell CM, Randolph L, Raskin S, Rosell J, Rubin K, Seashore M, Schaaf CP, Scheuerle A, Schultz M, Schorry E, Schnur R, Siqveland E, Tkachuk A, Tonsgard J, Upadhyaya M, Verma IC, Wallace S, Williams C, Zackai E, Zonana J, Lazaro C, Claes K, Korf B, Martin Y, Legius E, Messiaen L Hum. Mutat. 2015 Jul
- Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study.
- O'Brien JL, Langlois PH, Lawson CC, Scheuerle A, Rocheleau CM, Waters MA, Symanski E, Romitti PA, Agopian AJ, Lupo PJ Birth Defects Res. Part A Clin. Mol. Teratol. 2015 Jun
- De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay.
- Chong JX, McMillin MJ, Shively KM, Beck AE, Marvin CT, Armenteros JR, Buckingham KJ, Nkinsi NT, Boyle EA, Berry MN, Bocian M, Foulds N, Uzielli ML, Haldeman-Englert C, Hennekam RC, Kaplan P, Kline AD, Mercer CL, Nowaczyk MJ, Klein Wassink-Ruiter JS, McPherson EW, Moreno RA, Scheuerle AE, Shashi V, Stevens CA, Carey JC, Monteil A, Lory P, Tabor HK, Smith JD, Shendure J, Nickerson DA, Bamshad MJ Am. J. Hum. Genet. 2015 Mar 96 3 462-73
- The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy.
- Namazy J, Cabana MD, Scheuerle AE, Thorp JM, Chen H, Carrigan G, Wang Y, Veith J, Andrews EB J. Allergy Clin. Immunol. 2015 Feb 135 2 407-12
- Birth defects, causal attributions, and ethnicity in the national birth defects prevention study.
- Case AP, Royle M, Scheuerle AE, Carmichael SL, Moffitt K, Ramadhani T J Genet Couns 2014 Oct 23 5 860-73
Appendix III: Syndromes Glossary. In Cabana MD, ed. The 5-Minute Pediatric Consult. 7th ed.
Scheuerle AE. (2015). Wolters Kluwer; 1027-1033.
Genetics in the Clinic: Clinical, Ethical and Social Implications for Primary Care.
(Ed.) (2001). St. Louis: Mosby
Understanding Genetics: A Guide for Couples and Families.
(Ed.) (2005). Westport, CT: Greenwood Publishing.
Clinical Genetics and Dysmorphology. In Cabana M, ed. Rudolph's Pediatrics Self-Assessment and Board Review. 22nd ed.
Scheuerle A. (2014). San Francisco: McGraw Hill; 220-236.
Review of Embryology and Clinical Genetics. In Advances in Plastic Surgery.
Scheuerle A. (1998).
Honors & Awards
- Best Pediatric Specialists
D Magazine (2015)
- Distinguished Service Award
National Birth Defect Prevention Network (2010)
- First place poster award
National Birth Defect Prevention Network (2009)
- Outstanding Pediatric Subspecialist
D Magazine (2004-2014)
- Phi Beta Kappa
- AAP - Section Executive Committee (2013-2015)
- AAP - ListServ Working Group (2011)
- North Texas Bioethics Network (2005)
- Pediatric Society of Greater Dallas (2004)
- Bioethics Committee, Medical City Dallas Hospital (2003-2014)
- National Birth Defects Prevention Network (1998)
- Houston Bioethics Network (1997-1998)
- AAP - Section of Genetics and Birth Defects (1995)
- American College of Medical Genetics and Genomics (1995)
- American Society of Human Genetics (1990)
- American Academy of Pediatrics (AAP) (1988)