Lani Wu, Ph.D.

Dr. Lani Wu has come to biology by way of pure mathematics, computer science and electrical engineering and has worked together with Dr. Altschuler as a team since graduate school. Drs. Altschuler and Wu graduated from the University of California at San Diego with doctorates in mathematics.

Their work focused primarily on applications of systems of nonlinear partial differential equations to problems in differential geometry and topology. They left the faculty at Princeton University to join the fledgling research division at Microsoft, where they founded a number of research efforts including projects in video compression, semantic search, and speech/noise separation from multi-microphone input.

Prior to arriving at the UT Southwestern, Drs. Altschuler and Wu were at Rosetta Informatics and Fellows at the Bauer Center for Genomics Research at Harvard University. Drs. Altschuler and Wu combine their backgrounds in mathematics, signal processing, data analysis, and biology in their current focus on uncovering design principles underlying the spatial-temporal organization of molecular networks.

Undergraduate	National Taiwan University - Taiwan (), Mathematics
Graduate School	University of California-san Diego (1990)

• Cancer
• Cell polarity
• Cellular heterogeneity
• Systems biology

Featured Publications

On the spontaneous emergence of polarity.

Altschuler SJ, Angenent SB, Wang Y, Wu LF Nature, August 2008 454 886-890

Image-based multivariate profiling of drug responses from single cells

Loo, L.H., Wu, L., Altschuler, S.J. Nature Methods May 2007 4(5) 445-53

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity

Marco, E., Wedlich-Soldner, R., Li, R., Altschuler, S.J., Wu, L.F. Cell April 2007 129 411-422

Multi-dimensional drug profiling by automated microscopy.

Perlman, Z.E., Slack, M.D., Feng, Y., Mitchison, T.J., Wu, L.F., Altschuler, S.J. Science 2004 306(5699) 1194-1198

Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.

Wedlich-Soldner, R., Altschuler, S.J., Wu, L.F., Li, R. Science 2003 299(5610) 1231-1235

On the spontaneous emergence of polarity

Altschuler SJ, Angenent SB, Wang Y, Wu LF Nature August 2008 454 886-890

An actin-based wave generator organizes cell motility

Weiner, O.D., Marganski, W.A., Wu, L.F., Altschuler, S.J., Krischner, M.W. PLOS Biology August 2007 5 221

Image-based multivariate profiling of drug responses from single cells

Loo, L.H., Wu, L., Altschuler, S.J. Nature Methods May 2007 2007 445-53

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity

Marco, E., Wedlich-Soldner, R., Li, R., Altschuler, S.J., Wu, L.F. Cell April 2007 129 411-22

Systems-level analyses identify extensive coupling among gene expression machines

Maciag, K., Altschuler, S.J., Slack, M.D., Krogan, N.J., Emili, A., Greenblatt, J.F., Maniatis, T., Wu, L.F. Molecular Systems Biology January 2006 2(1) msb400045-E1-msb400045-E14

• UTSW Endowed Scholar
  (2005)