Matthew Goldberg, Ph.D.

Assistant Professor

Department: Neurology & Neurotherapeutics, Psychiatry

Graduate Programs: Neuroscience

Biography

Dr. Goldberg graduated with a B.S. in physics from the University of Michigan where he conducted research on the structure of proteins using nuclear magnetic resonance in the laboratory of Dr. Gerhard Wagner. He earned his Ph.D. in molecular biophysics and biochemistry from Yale University, working in the laboratories of Dr. Arthur L. Horwich and Dr. Robert O. Fox. He received his postdoctoral training in neurodegenerative diseases at Harvard Medical School and Brigham and Women's Hospital in Boston working in the laboratories of Dr. Peter T. Lansbury and Dr. Jie Shen. Using gene targeting while in the laboratory of Dr. Jie Shen, Dr. Goldberg generated mice with loss-of-function mutations in the Parkin and DJ-1 genes linked to parkinsonism in humans.

Dr. Goldberg joined the faculty at UT Southwestern Medical Center in September 2005. He is an active member of the Neuroscience Graduate Program. His research is focused on identifying the mechanisms of neuronal degeneration in Parkinson's disease and investigating the roles of mitochondrial dysfunction, oxidative stress and genetic mutations in Parkin, DJ-1, PINK1, alpha-synuclein and LRRK2 that cause inherited forms of Parkinson’s disease. He is a member of the LRRK2 Biology Consortium and the Animal Models Steering Committee of the Michael J. Fox Foundation for Parkinson’s Research. View the Goldberg Lab page: http://www.utsouthwestern.edu/labs/goldberg-matthew/

Education

Undergraduate University of Michigan-Ann Arbor (1990), Physics
Graduate School Yale University (1998), Biochemistry

Research Interests

  • Animal models
  • Genetically inherited forms of Parkinson's disease
  • Mouse behavior
  • Neurodegeneration
  • Ubiquitin and protein degradation

Publications

Featured Publications Legend

Featured Publications

Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.

Hennis MR, Marvin MA, Taylor CM, Goldberg MS Neurobiol. Dis. 2013 Sep

Parkin-Dependent Degradation of the F-box protein Fbw7ß Promotes Neuronal Survival in response to oxidative stress by Stabilizing Mcl-1.

Ekholm-Reed S, Goldberg MS, Schlossmacher MG, Reed SI Mol. Cell. Biol. 2013 Jul

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1-/- mice.

Nguyen TA, Frank-Cannon T, Martinez TN, Ruhn KA, Marvin M, Casey B, Treviño I, Hong JJ, Goldberg MS, Tansey MG J Neuroinflammation 2013 Apr 10 1 50

Behavioral and Neurotransmitter Abnormalities in Mice Deficient for Parkin, DJ-1 and Superoxide Dismutase

Hennis MR, Seamans KW, Marvin MA, Casey BH, Goldberg MS PLoS ONE 2013 in press

A mutation in CLOCK leads to altered dopamine receptor function.

Spencer S, Torres-Altoro MI, Falcon E, Arey R, Marvin M, Goldberg M, Bibb JA, McClung CA Journal of neurochemistry 2012 Jul

Number and brightness analysis of LRRK2 oligomerization in live cells.

James NG, Digman MA, Gratton E, Barylko B, Ding X, Albanesi JP, Goldberg MS, Jameson DM Biophys. J. 2012 Jun 102 11 L41-3

Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.

Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimoto K, Doi T, Iguchi-Ariga SM, Ariga H PLoS ONE 2012 7 5 e38144

Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the Clock?19 mouse model of mania.

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA Neuropsychopharmacology 2011 Jun 36 7 1478-88

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.

Wen Y, Li W, Poteet EC, Xie L, Tan C, Yan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg MS, She H, Mao Z, Simpkins JW, Yang SH J. Biol. Chem. 2011 May 286 18 16504-15

Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

Tran TA, Nguyen AD, Chang J, Goldberg MS, Lee JK, Tansey MG PLoS ONE 2011 6 8 e23660

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