Research in the Hsieh laboratory explores the development and function of resident adult neural stem cells, which are a source of inherent plasticity in the mammalian brain center (hippocampus) critical for learning and memory. We study neural stem cells using a range of novel genetic, pharmacological, cellular, molecular, and imaging methods. A major focus of our lab is to understand the transcriptional/epigenetic regulatory circuitry that guides neural stem cell fate decisions in both normal and pathological states.


University of California-San D , Biochemistry
University of California-San D , Cell Biology
Graduate School
Johns Hopkins Univ (2000), Biology

Research Interest

  • Adult neurogenesis and epilepsy
  • Cancer stem cells
  • Epigenetic regulation
  • Neurogenic small molecules
  • Stem cell biology


Featured Publications LegendFeatured Publications

Neuroscience. Neural stem cells, excited.
Hsieh J, Schneider JW Science 2013 Mar 339 6127 1534-5
Epigenetics and epilepsy.
Roopra A, Dingledine R, Hsieh J Epilepsia 2012 Dec 53 Suppl 9 2-10


Featured Books Legend Featured Books

Honors & Awards

  • The American Epilepsy Society Young Investigator Travel Award
  • The Citizen?s United for Epilepsy Foundation Multidisciplinary Award
  • The Ellison Medical Foundation New Scholar Award in Aging
  • The Esther A. & Joseph Klingenstein Fellowship Award in the Neurosciences
  • UTSW President’s Research Council Distinguished Young Researcher Award

Professional Associations/Affiliations

  • American Epilepsy Society (2013)
  • International Society for Stem Cell Research (2011)
  • Society for Neuroscience (2000)