Biography

Download Curriculum Vitae

Boothman, David A.
Professor, Associate Director for Translational Research

University of Michigan B.S. 1981 Microbiology
University of Miami Ph.D. 1986 Microbiology & Immunology

1986-1989 Postdoctoral Fellow, Mol. Pharm. & Cell Growth and Reg., Harvard Medical School, Dana-Farber Cancer Inst.
1989-1993 Assistant Professor, Dept. Radiation Oncology, Div. Cancer Biology, U Michigan
1993-1996 Assistant Professor, Dept. of Human Oncology, U W-Madison
1996-1998 Associate Professor, Vice Chairman of Basic Research, Human Oncology, U W-Madison
1998-2001 Associate Professor, Radiation Oncology, Pharmacology, Case Western Reserve University
2001-2005 Professor, Radiation Oncology, Pharmacology, Case Western Reserve University
2002-2005 Associate Dir Basic Research, Distinguished Inv. Award, Case Western Reserve University
2005-present Robert and Virginia Payne Professor of Oncology, UT Southwestern
2005-present Co-Director, Program in Cell Stress and Cancer Nanomedicine, UT Southwestern
2005-present Associate Dir. Translational Research, UT Southwestern

1993-1999 NIH, Radiation Biol., Chem. Path B Study Section
1997-2002 NIH ET-2 Study Section
2002-2005 DT Study Section
1997-Present DOD Prostate and Breast Cancer
1997-Present DOE/NASA Low Dose IR Effects
1999-Present NIH Program Project/SPORE Grants
2005-Present NIH Traineeship Awards
2007-Present RTB Study Section

HONORS
1985 AACR-Upjohn Travel Award
1985 Dir., Eastern Student Research Forum (AMA)
1988 NRSA Tumor Biology Fellowship
1993-2005 Distinguished Investigator Award, Case Western Reserve University
2005-Pres Robert B. and Virginia Payne Professor of Oncology

2012-2014 AACR-PanCan Innovator Award, George and June Block Foundation

Recent peer-reviewed pubs (from >100):

  1. Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA. Development of β-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. 2005; Clinical Cancer Research 11:3055-64.
  2. Bentle M, Reinicke K, Bey E, Spitz D, Boothman DA. Calcium regulation of PARP-1 hyperactivation for altered cellular metabolism and inhibition of DNA repair. 2006; J Biological Chemistry 281:33684-33696.
  3. Nasongkla N, Bey E, Ren J, Khemtong C, Setti-Guthi J, Chin S-F, Sherry AD, Boothman DA, Gao, J.  Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. 2006; Nano Letters 6:2427-2330.
  4. Wang F, Blanco E, Ai H, Boothman DA, Gao, J.  Modulating ß-lapaachone release from polymer millirods through cyclodextrin complexation. 2006;  J. Pharm Sci. 95:2309-2319.
  5. Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA.  An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. 2007; Proc Natl Acad Sci, USA 104:11832-11837. PMCID: PMC1913860.
  6. Dong, Y, Chin S-F, Blanco E, Bey EA, Kabbani W, Xie X-J, Bornmann WG, Gao J, Boothman DA.  Intratumoral delivery of ß-lapachone via polymer implants for prostate cancer therapy. 2009; Clinical Cancer Research 15(1):131-139. PMID: 19118040, PMIC:PMC2845536.
  7. Khemtong C, Kessinger CW, Ren J, Bey EA, Boothman DA, Sherry AD, Gao J.  Turning “ON” the superparamagnetic nanoprobes for cancer molecular imaging.  2009; Cancer Research, 69(4):1651-1658.  PMID: 19190328, PMIC:PMC2821739.
  8. Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA.  The receptor interacting protein (RIP1) inhibits p53 induction through NF-kB activation and confers a worse prognosis in glioblastoma. 2009; Cancer Research 69(7):2809-2816.  PMID 19339267. PMIC:2859885.
  9. Mukherjee B, McEllinB, CamachoCV, TomimatsuN, Sirasanagandala S, Nannepaga S, HatanpaaHJ, MickeyB, Madden C, Elizabeth Maher E,  Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S. EGFRvIII and DNA Double-Strand Break Repair:  A Molecular Mechanism for Radioresistance in Glioblastoma. 2009; Cancer Research 69(10):4252-4259. PMID 19435898, PMIC:PMC2694953.
  10. Park S, Zhao D, Hatanpaa KJ, Mickey BJ, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar V, Chauncey SS, Habib AA.  RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and downregulation of PTEN.  2009; Cancer Research 69(10): 4107-4115. PMID 19435890, PMIC:PMC2683913.
  11. Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP.  Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.  2009; Cancer Research 69(19):7644-7652. PMID: 19789349; PMIC:PMC2760010.
  12. Araki S, Eitel JA, Batuello CN, Bijangi-Vishehsaraei K, Xie XJ, Danielpour, D, Pollok KE, Mayo LD, Boothman DA. TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.  2010; J. Clinical Investigation, 120(1): 290-302.  PMID 19955655, PMIC:PMC2798681.
  13. Dong Y, Bey EA, Li L, Kabbani W, Yan J, Xie X-J, Hsieh JT, Gao J, and Boothman DA. Prostate cancer radiosensitization through poly(ADP-ribose) polymerase-1 hyperactivation. 2010; Cancer Research, 70(20): 8088-8096. PMCID:PMC2955807.
  14. Huang X, Dong Y, Bey EA, Kilgore, JA, Bair JS, Li L-S, Bey EA, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis. 2012; Cancer Research, 72 (12): 3038-3046.  PMID22532167–PMC Journal In Process.

 

Education

Undergraduate University of Michigan-Ann Arbor (1980), Microbiology
Graduate School University of Miami (1986), Microbiology

Research Interest

  • Altered Metabolism in cancer cells, +/-radio- /chemo-therapies
  • IGF-1 Pathway Regulation
  • Repair of DNA Double-Strand Breaks and Mismatch lesions
  • Stress-Inducible and Noncaspase-Mediated Gene Apoptosis
  • Targeted Cancer Therapeutics
  • Tumor-specific BER alterations using NQO1 bioactivatable drugs

Publications

Featured Publications LegendFeatured Publications

Honors & Awards

  • Distinguished Scientist Endowment
    Case Western Reserve University (2000)
  • Radiation Research Travel Award, Dublin, Ireland
    Radiation Research Society (1999)
  • Upjohn Travel Award
    American Assoc. for Cancer Research (1985)