Xian-Jin Xie, Ph.D.

Dr. Xie joined the Department of Clinical Sciences (then Center for Biostatistics and Clinical Science) and Simmons Comprehensive Cancer Center in June, 2005. He previously was an associate research scientist at the University of Iowa.

Dr. Xie’s research focuses on biostatistical methodologies and the application of those methodologies to collaborative research between biomedical and clinical disciplines. He earned a Doctorate and Master’s degree in biostatistics, as well as a Master’s degree in neurobiology, from the University of Iowa. Dr. Xie received his bachelor’s degree from Beijing University in China.

Undergraduate	Beijing University - China (), Biophysics
Graduate School	University of Iowa (2005)

• Biomedical research design
• Biostatistics
• Clinical trials methodologies
• Collaborative cancer research and bioinformatics

Featured Publications

BAP1 loss defines a new class of renal cell carcinoma

Peña-Llopis S, Vega-Rubín-de-Celis S, Liao A, Leng N, Pavía-Jiménez A, Wang S, Yamasaki T, Zhrebker L, Sivanand S, Spence P, Kinch L, Hambuch T, Jain S, Lotan Y, Margulis V, Sagalowsky AI, Summerour PB, Kabbani W, Wong SW, Grishin N, Laurent M, Xie XJ, Haudenschild CD, Ross MT, Bentley DR, Kapur P, Brugarolas J. Nature Genetics 2012 44 7 751-759

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma

63. Sivanand S, Pena-Llopis S, Zhao H, Kucejova B, Pavia-Jimenez A, Yamasaki T, Spence P, Purushotham A, McBride D, Gillen J, Wolff NC, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross M, Bentley D, Kabbani W, Xie XJ, Williams N, Kapur P, Brugarolas J. Science Translational Medicine 2012 4 137 137ra75

A phase I dose escalation study of stereotactic body radiation therapy for low and intermediate risk prostate cancer

Boike T, Lotan Y, Cho LC, Brindle J, DeRose P, Xie XJ, Yan J, Foster R, Pistenmaa D, Perkins A, Cooley S, Timmerman R Journal of Clinical Oncology 2011 29 15 2020-2026

Increasing the power: Goodness-of-fit tests for ordinal logistic regression models with continuous covariates

Xie XJ and Bian A JP Journal of Biostatistics October 2009 3(3) 225-246

Bayesian optimal discovery procedure for simultaneous significance testing

Cao J, Xie XJ, Zhang S, Whitehurst A, White M BMC Bioinformatics 2009 doi: 10.1186/1471-2105-10

Increasing the power: A practical approach to Goodness-of-Fit test for logistic regression models with continuous predictors

Xie XJ, Pendergast J and Clarke WR Computational Statistics & Data Analysis January 2008 52(5) 2703-2713

Accounting for intraclass correlations and controlling for baseline differences in a cluster-randomized evidence based practice intervention study

Xie XJ, Titler M, and Clarke WR Worldviews on Evidence-Based Nursing 2008 5(2) 95-101

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

Whitehurst AW, Bodemann BO, Cardenas J, Ferguson D, Girard L, Payton M, Minna JD, Michnoff C, Hao W, Roth MG, Xie X-J, White MA Nature April 2007 446 (7137) 815-819

• American Statistical Association
• International Biometric Society (ENAR)
• Society for Clinical Trials
• The Society for Neuroscience (former member)