Avanthi Shah, M.D. Titles and Appointments Assistant Professor Schools Medical School Departments Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Avanthi Tayi Shah, M.D. is an Assistant Professor of Pediatrics at UTSW, where she is developing the Precision Oncology Program within the Division of Hematology-Oncology. She also leads the Cancer Genetics Clinic at Children's Health Plano. She is a leader in translational genomics which aims to improve human health by building on discoveries made through genetics research and applying them in the clinical setting. Her career goal is to improve outcomes for pediatric oncology patients by utilizing genomic techniques, such as liquid biopsy and tumor sequencing. After earning her medical degree and completing her residency in pediatrics at UTSW, she completed a fellowship in pediatric hematology/oncology at Stanford University/Lucile Packard Children’s Hospital. She joined the lab of Dr. Alejandro Sweet-Cordero, where her interests included the integration of DNA and RNA sequencing in pediatric oncology, as well as the design of a circualting tumor DNA assay for pediatric sarcomas. Dr. Shah served on the faculty of UCSF Benioff Children's Hospital San Francisco as Director of the Pediatric Cancer Precision Medicine Program and Director of the Pediatric Hereditary Cancer Program before coming to UTSW. Education Medical School UT Southwestern Medical School (2009) Residency UT Southwestern/Children's Medical Center (2012), Pediatrics Fellowship Stanford University/Lucile Packard Children's Hospital (2016), Pediatric Hematology/oncology Research Interest Circulating tumor DNA Hereditary cancer Pediatric sarcoma Precision medicine Publications Feasibility of Atezolizumab in Combination With Chemotherapy for Children With Relapsed or Refractory Solid Tumors Campbell ME, Stutzman S, Primeaux S, Sida D, Lee M, Shah AT, Sadanand A, Sokol E, Collins NB, Turpin B, Navai S, Albert K, Laetsch TW, Rakheja D, Chen KS, Gerber DE, Koh AY Pediatric Blood and Cancer 2025 Dec 72 An Unusual Parotid Mass in a 14-Year-Old Female Leavitt T, Shah AT, Singh V, Mitchell RB, Liu CC Ear, Nose and Throat Journal 2024 Jul 103 403-405 Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA Clinical Cancer Research 2024 Feb 30 849-864 A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA Molecular Cancer Therapeutics 2021 Oct 20 2016-2025 Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures Pfeil J, Sanders LM, Anastopoulos I, Geoffrey Lyle A, Weinstein AS, Xue Y, Blair A, Beale HC, Lee A, Leung SG, Dinh PT, Shah AT, Breese MR, Patrick Devine W, Bjork I, Salama SR, Alejandro Sweet-Cordero E, Haussler D, Vaske OM PLoS Computational Biology 2020 Apr 16 Genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies Schott C, Shah AT, Sweet-Cordero EA 2020 1-19 Complete response to PD-1 inhibition in an adolescent with relapsed clear cell adenocarcinoma of the cervix predicted by neoepitope burden and APOBEC signature Levinson A, Lee AG, Martell HJ, Breese MR, Zaloudek C, Van Ziffle J, Laguna B, Leung SG, Chen MD, Chen LM, Pfeil J, Ladwig NR, Shah AT, Behroozfard I, Rao AA, Salama SR, Sweet-Cordero EA, Stieglitz E JCO Precision Oncology 2020 4 1321-1326 Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer Vaske OM, Bjork I, Salama SR, Beale H, Shah AT, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D JAMA Network Open 2019 Oct 2 e1913968 Genome-informed targeted therapy for osteosarcoma Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, Dubois SG, Hawkins DS, Sweet-Cordero EA Cancer discovery 2019 Jan 9 46-63 Comparative RNA-seq analysis AIDS in diagnosis of a rare pediatric tumor Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Geoffrey Lyle A, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Alejandro Sweet-Cordero E, Vaske OM Cold Spring Harbor Molecular Case Studies 2019 5 Results 1-10 of 12 1 2 Next Last Books Featured Books Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies. In Current Advances in the Science of Osteosarcoma Courtney Schott, Avanthi Tayi Shah, E. Alejandro Sweet-Cordero (2020). Springer Honors & Awards Cary Council DocStars Award (2023-2023) St. Baldrick's Foundation Fellowship (2015-2018) Professional Associations/Affiliations American Association of Cancer Research American Association of Pediatrics American Society of Pediatric Hematology/Oncology Children's Oncology Group Connective Tissue Oncology Society
