James Amatruda, M.D., Ph.D.

Medical School	Washington University School of Medicine (1993)
Residency	Brigham and Women's Hospital (1996), Internal Medicine
Fellowship	Consglio Nazionale delle Ricerche (1997), Molecular Genetics
Fellowship	Dana-Farber Cancer Institute (1999), Hematology and Oncology
Fellowship	Children's Hospital of Boston (2004), Research

• Cancer
• Hematology/Oncology
• Pediatrics
• Skin (Melanoma & Sarcoma) Cancer
• Urologic Cancer

• Primary Interests
• Germ Cell Tumors
• Ovarian Cancer, Masses & Tumors
• Sarcoma
• Sickle Cell Disease
• Testicular Cancer

• Animal Models of Cancer
• Cancer Genetics
• DNA Damage Response
• Testicular Cancer
• Zebrafish

Featured Publications

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.

Verduzco D, Shepard Dovey J, Shukla A, Kodym E, Skaug BA, Amatruda JF Mol. Cancer Res. 2012 Sep

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L J. Biol. Chem. 2012 Jun 287 27 23246-54

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis.

Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF Disease models & mechanisms 2011 Oct

Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish.

Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF Proc. Natl. Acad. Sci. U.S.A. 2011 Aug 108 32 13153-8

Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.

Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF Int. J. Androl. 2011 Aug 34 4 Pt 2 e218-33

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L Sci Signal 2011 4 157 ra4

Fetal and neonatal germ cell tumors.

Frazier AL, Weldon C, Amatruda J Semin Fetal Neonatal Med 2012 Aug 17 4 222-30

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.

Moro E, Ozhan-Kizil G, Mongera A, Beis D, Wierzbicki C, Young RM, Bournele D, Domenichini A, Valdivia LE, Lum L, Chen C, Amatruda JF, Tiso N, Weidinger G, Argenton F Developmental biology 2012 Apr

Children's Oncology Group's 2013 blueprint for research: Rare tumors.

Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G; on behalf of the COG Rare Tumors Disease Committee Pediatr Blood Cancer. 2012 2012 Dec 19. doi:10.1002/pbc.24428. [Epub ahead of print]

C/EBP transcription factors mediate epicardial activation during heart development and injury.

Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. Science 2012 338 6114 1599-603

• Outstanding Teacher, MS1 Class
  (2011)
• Outstanding Teacher, MS1 Class
  (2010)
• Health Care Heroes Award, Dallas Business Journal
  (2009)
• Outstanding Teacher, MS1 Class
  (2009)
• Outstanding Teacher, MS1 Class
  (2007)
• Horchow Family Endowed Scholar in Pediatrics
  (2005)
• William Guy Forbeck Research Foundation Scholar
  (2003)
• Arnold Dunne Award
  (1994)
• Alpha Omega Alpha
  (1993)