Thomas Carroll, Ph.D. Titles and Appointments Director, Basic Science Research in Nephrology Professor Endowed Title The NCH Corporation Distinguished Chair in Molecular Transport School Medical School Department Internal Medicine | Molecular Biology Graduate Programs Biomedical Engineering, Genetics, Development and Disease Biography Thomas Carroll, Ph.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Nephrology. He serves as Director of Basic Science Research in Nephrology, Director of the Mechanisms of Disease and Translational Science Graduate Program, and Director of the Summer Undergraduate Research Institute of the Study of Kidney Diseases. Originally from Woodland Hills, California, Dr. Carroll holds a bachelor's degree in biology from the University of California, Davis. He earned his doctorate in zoology from the University of Texas at Austin, and subsequently completed a postdoctoral fellowship at Harvard University in Boston. Dr. Carroll joined the UT Southwestern faculty in 2004. Dr. Carroll is internationally recognized as one of the top scientists in kidney development and research in polycystic kidney disease. He is widely cited for his important work on the mechanisms whereby members of the Wnt family of glycoproteins regulate the formation of new nephrons in the developing kidney. He also published a paper describing a signaling mechanism whereby stromal epithelial cells regulate kidney progenitor cell differentiation and proliferation through modulation of the Hippo signaling pathway. Dr. Carroll's work in the understanding of the signaling mechanisms involved in kidney induction during development has important implications for kidney disease and possible regenerative strategies. Dr. Carroll's laboratory has been supported by grants from the National Institutes of Health, and he has been recognized for his mentorship of new investigators and junior faculty members. He has directly overseen the training of graduate students, postdoctoral trainees, and medical students. Education Undergraduate Uni of California-Davis (1992), Biology Graduate School University of Texas-Austin (1999), Zoology Research Interest Cancer Developmental Biology Metabolism Single cell transcriptomics Stem/progenitor cells Tissue engineering and regeneration Publications Featured Publications Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. Carter P, Schnell U, Chaney C, Tong B, Pan X, Ye J, Mernaugh G, Cotton JL, Margulis V, Mao J, Zent R, Evers BM, Kapur P, Carroll TJ, J Clin Invest 2021 Jun 131 11 Identification and characterization of cellular heterogeneity within the developing renal interstitium. England AR, Chaney CP, Das A, Patel M, Malewska A, Armendariz D, Hon GC, Strand DW, Drake KA, Carroll TJ, Development 2020 Aug 147 15 Stromal ?-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ, Development 2020 07 147 21 Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ Dev. Biol. 2018 Apr Lkb1 deficiency confers glutamine dependency in polycystic kidney disease. Flowers EM, Sudderth J, Zacharias L, Mernaugh G, Zent R, DeBerardinis RJ, Carroll TJ Nat Commun 2018 Feb 9 1 814 Myc cooperates with beta-catenin to drive gene expression in the nephron progenitor cells. Pan X, Karner CM, Carroll TJ Development 2017 Oct The bioengineered kidney: science or science fiction? Oxburgh L, Carroll TJ Curr. Opin. Nephrol. Hypertens. 2016 May Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ Nat. Cell Biol. 2013 Sep 15 9 1035-44 Defining the Signals that Constitute the Nephron Progenitor Niche. Carroll TJ, Das A J. Am. Soc. Nephrol. 2013 Apr Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ Development 2011 Apr 138 7 1247-57 Results 1-10 of 58 1 2 3 4 5 Next Last Honors & Awards Distinguished Researcher AwardAmerican Society of Nephrology (2023) Scientist Development GrantAmerican Heart Association (2007-2012) Gottschalk Career Development AwardAmerican Society of Nephrology (2005-2007) Professional Associations/Affiliations American Heart Association American Kidney Foundation American Society of Nephrology Society for Developmental Biology
