Download Curriculum Vitae

EmmanouilS. Brilakis, M.D., Ph.D., FACC, FAHA, FESC, FSCAI, is Director of the Cardiac Catheterization Laboratories at VA North Texas Healthcare System and an Associate Professor of Medicine at University of Texas Southwestern Medical Center.

After graduating from Lycee Leonin de Patissia, Dr. Brilakis received his medical degree from the National Kapodistrian University of Athens, Greece. He trained in Internal Medicine, Cardiovascular Diseases and Interventional Cardiology at the Mayo Clinic. He also completed a Masters in Clinical Research at the Mayo Clinic and a PhD in Clinical Research at the National Kapodistrian University of Athens, Greece. Dr. Brilakis leads a very active clinical trial group investigating the percutaneous treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, intracoronary imaging, and antiplatelet treatment optimization post coronary stenting.

Dr. Brilakis has authored or co-authored over 280 manuscripts and has written the Manual of CTO Interventions. He receives funding from the National Institutes of Health, the Department of Veterans Affairs and industry. He is the PI and study chair of VA Cooperative Trial #571, Drug-Eluting Stenting
Stents in Saphenous Vein Graft Angioplasty). He is a reviewer and editorial board member for several journals and grant agencies and is lecturing and proctoring at several institutions in the United States and



Medical School National University of Athens (1995)
Residency General Military Hospital (1997), Internal Medicine
Internship Mayo Clinic (1998), Internal Medicine
Residency Mayo Clinic (2000), Internal Medicine
Fellowship Mayo Clinic (2003), Cardiovascular Disease
Fellowship Mayo Clinic (2004), Interventional Cardiology

Research Interest

  • Chronic Total Occlusion interventions
  • Intravascular imaging and coronary physiology
  • Perioperative management of coronary stents
  • Saphenous vein grafts: interventions and medical treatment


Featured Publications LegendFeatured Publications

Wire externalization versus "rendez-vous" for successfully completing retrograde chronic total occlusion interventions.
Rangan BV, Brilakis ES Catheter Cardiovasc Interv 2014 Aug 84 2 338-9
Fast virtual functional assessment of intermediate coronary lesions using routine angiographic data and blood flow simulation in humans: comparison with pressure wire - fractional flow reserve.
Papafaklis MI, Muramatsu T, Ishibashi Y, Lakkas LS, Nakatani S, Bourantas CV, Ligthart J, Onuma Y, Echavarria-Pinto M, Tsirka G, Kotsia A, Nikas DN, Mogabgab O, van Geuns RJ, Naka KK, Fotiadis DI, Brilakis ES, Garcia-Garcia HM, Escaned J, Zijlstra F, Michalis LK, Serruys PW EuroIntervention 2014 Jul
Outcomes With First- Versus Second-Generation Drug-Eluting Stents in Coronary Chronic Total Occlusions (CTOs): A Systematic Review and Meta-Analysis.
Lanka V, Patel VG, Saeed B, Kotsia A, Christopoulos G, Rangan BV, Mohammad A, Luna M, Garcia S, Abdullah SM, Grodin J, Hastings JL, Banerjee S, Brilakis ES J Invasive Cardiol 2014 Jul 26 7 304-10
Extent of coronary artery disease and outcomes after ticagrelor administration in patients with an acute coronary syndrome: Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial.
Kotsia A, Brilakis ES, Held C, Cannon C, Steg GP, Meier B, Cools F, Claeys MJ, Cornel JH, Aylward P, Lewis BS, Weaver D, Brandrup-Wognsen G, Stevens SR, Himmelmann A, Wallentin L, James SK Am. Heart J. 2014 Jul 168 1 68-75.e2
Application of the "Hybrid Approach" to Chronic Total Occlusions in Patients With Previous Coronary Artery Bypass Graft Surgery (from a Contemporary Multicenter US Registry).
Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham JA, Michael TT, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES Am. J. Cardiol. 2014 Jun 113 12 1990-1994
Developments in coronary chronic total occlusion percutaneous coronary interventions: 2014 state-of-the-art update.
Brilakis ES, Karmpaliotis D, Werner GS, Spratt JC, Uretsky BF, Luna M, Banerjee S J Invasive Cardiol 2014 Jun 26 6 261-6


Featured Books Legend Featured Books

Honors & Awards

  • Outstanding Research Mentor Award, Internal Medicine House Staff, University of Texas Southwestern Medical Center
  • Researcher of the Year Award. VA North Texas Healthcare System and Dallas VA Research Corporation
  • Researcher of the Year Award. VA North Texas Healthcare System and Dallas VA Research Corporation
  • CRT 2009 Young Leadership Award for Interventional Cardiology
  • William W. Parmley Young Author Achievement Award. Journal of the American College of Cardiology
  • Mayo Clinic Individual Award for Excellence
  • Outstanding Achievement Award, Mayo Clinic Internal Medicine Residency Program

Professional Associations/Affiliations

  • American College of Cardiology
  • American College of Physicians
  • American Heart Association
  • American Medical Association
  • Society for Cardiovascular Angiography and Interventions