Emmanouil Brilakis, M.D.

Associate Professor

Department: Internal Medicine


Download Curriculum Vitae

EmmanouilS. Brilakis, MD, PhD, FACC, FAHA, FESC, FSCAI, is Director of the Cardiac Catheterization Laboratories at VA North Texas Healthcare System and an Associate Professor of Medicine at University of Texas Southwestern Medical School.

After graduating from Lycee Leonin de Patissia, Dr. Brilakis received his medical degree from the National Kapodistrian University of Athens, Greece. He trained in Internal Medicine, Cardiovascular Diseases and Interventional Cardiology at the Mayo Clinic. He also completed a Masters in Clinical Research at the Mayo Clinic and a PhD in Clinical Research at the National Kapodistrian University of Athens, Greece. Dr. Brilakis leads a very active clinical trial group investigating the percutaneous treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, intracoronary imaging, and antiplatelet treatment optimization post coronary stenting.

Dr. Brilakis has authored or co-authored over 230 manuscripts and has written the Manual of CTO Interventions. He receives funding from the National Institutes of Health, the Department of Veterans Affairs and industry. He is the PI and study chair of VA Cooperative Trial #571, Drug-Eluting Stenting
Stents in Saphenous Vein Graft Angioplasty). He is a reviewer and editorial board member for several journals and grant agencies and is lecturing and proctoring at several institutions in the United States and



Medical School National University of Athens (1995)
Residency General Military Hospital (1997), Internal Medicine
Internship Mayo Clinic (1998), Internal Medicine
Residency Mayo Clinic (2000), Internal Medicine
Fellowship Mayo Clinic (2003), Cardiovascular Disease
Fellowship Mayo Clinic (2004), Interventional Cardiology

Research Interests

  • Chronic Total Occlusion interventions
  • Intravascular imaging and coronary physiology
  • Perioperative management of coronary stents
  • Saphenous vein grafts: interventions and medical treatment


Featured Publications Legend

Featured Publications

Outcomes After Complete Versus Incomplete Revascularization of Patients With Multivessel Coronary Artery Disease: A Meta-Analysis of 89,883 Patients Enrolled in Randomized Clinical Trials and Observational Studies.

Garcia S, Sandoval Y, Roukoz H, Adabag S, Canoniero M, Yannopoulos D, Brilakis ES J. Am. Coll. Cardiol. 2013 Oct 62 16 1421-1431

Impact of prior coronary artery bypass graft surgery on chronic total occlusion revascularisation: insights from a multicentre US registry.

Michael TT, Karmpaliotis D, Brilakis ES, Abdullah SM, Kirkland BL, Mishoe KL, Lembo N, Kalynych A, Carlson H, Banerjee S, Lombardi W, Kandzari DE Heart 2013 Oct 99 20 1515-8

Procedural outcomes of revascularization of chronic total occlusion of native coronary arteries (from a multicenter United States registry).

Michael TT, Karmpaliotis D, Brilakis ES, Fuh E, Patel VG, Mogabgab O, Alomar M, Kirkland BL, Lembo N, Kalynych A, Carlson H, Banerjee S, Lombardi W, Kandzari DE Am. J. Cardiol. 2013 Aug 112 4 488-92

Outcomes of a preoperative "bridging" strategy with glycoprotein IIb/IIIa inhibitors to prevent perioperative stent thrombosis in patients with drug-eluting stents who undergo surgery necessitating interruption of thienopyridine administration.

Alshawabkeh LI, Prasad A, Lenkovsky F, Makary LF, Kandil ES, Weideman RA, Kelly KC, Rangan BV, Banerjee S, Brilakis ES EuroIntervention 2013 Jun 9 2 204-11

Preclosing large venous sheaths with perclose can facilitate advanced structural heart interventions.

Bagai J, Brilakis ES Catheter Cardiovasc Interv 2013 Mar 81 4 591

Chronic total occlusions: patient selection and overview of advanced techniques.

Garcia S, Abdullah S, Banerjee S, Brilakis ES Curr Cardiol Rep 2013 Feb 15 2 334

Results 1-10 of 113


Featured Books Legend

Featured Books


  • Researcher of the Year Award. VA North Texas Healthcare System and Dallas VA Research Corporation
  • Researcher of the Year Award. VA North Texas Healthcare System and Dallas VA Research Corporation
  • CRT 2009 Young Leadership Award for Interventional Cardiology
  • William W. Parmley Young Author Achievement Award. Journal of the American College of Cardiology
  • Mayo Clinic Individual Award for Excellence
  • Outstanding Achievement Award, Mayo Clinic Internal Medicine Residency Program

Professional Associations/Affiliations

  • American College of Cardiology
  • American College of Physicians
  • American Heart Association
  • American Medical Association
  • Society for Cardiovascular Angiography and Interventions