Andrew Feranchak, M.D.

Dr. Andrew Feranchak is a graduate of the University of Notre Dame and the University of Pittsburgh Medical School. He completed his internship and residency in Pediatrics at The Children’s Hospital in Pittsburgh and his fellowship in Pediatric Gastroenterology, Hepatology, and Nutrition at the University of Colorado Health Sciences and Children’s Hospital Denver. Dr. Feranchak’s clinical interests include cholestatic liver disease, assessment of nutritional and fat-soluble vitamin status, and gastrointestinal and liver complications of cystic fibrosis. His basic research interests include understanding the mechanisms of bile formation, biliary secretion, and liver cell volume regulation. He is the winner of the American Liver Foundation Postdoctoral Research Fellowship Award, the North American Society Pediatric Gastroenterology and Nutrition Fellow Research Award, the Children’s Digestive Health and Nutrition Foundation Silver Anniversary Award, and the Regal Award for excellence in gastroenterology and liver research. He is presently an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and the Children’s Medical Center, Dallas, Texas.

Medical School	Univ. of Pittsburgh School of Medicine (1992)
Residency	Children's Hospital of Philadelphia (1995), Pediatrics
Fellowship	University of Colorado Health Sciences Center (1999), Pediatric Gastroenterology
Research Fellowship	University of Colorado Health Science Center (1999), Hepatology

• Digestive & Liver Diseases (Gastroenterology)
• Pediatrics

• Primary Interests
• Cystic Fibrosis (CF) (ILD)
• Liver Disease

• Biophysical characterization of membrane ion channels
• Cell volume regulation
• Cholestatic liver disease
• Hepatobiliary transport
• Mechanisms of bile formation

Featured Publications

Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium

Feranchak AP, Lewis MA, Kresge C, Sathe M, Bugde A, Luby-Phelps K, Antich P, Fitz JG J Biol Chem 2010 285 8138-47

Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels

Feranchak AP, Doctor RB, Troetsch M, Brookman K, Johnson SM, Fitz JG Gastroenterol 2004 127 903-13

P38 MAP Kinase modulates liver cell volume through inhibition of membrane Na+ permeability

Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG J Clin Invest 2001 108 1495-1504

The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport.

Feranchak AP, Roman RM, Salter KD, Toker A, Fitz JG J Biol Chem 1999 274 30979-30986

Prospective long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen

Feranchak AP, Sontag MK, Wagener JS, Hammond KB, Accurso FJ, Sokol RJ J Pediatr 1999 135 601-10

Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.

29. Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP J Biol Chem January 2011 286 766-776

ATP release and P2 receptor-mediated secretion in small and large mouse cholangiocytes

Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser S, Alpini G, Feranchak AP Hepatology 2010 52 1819-1828

Identification and functional characterization of the intermediate conductance Ca2+-activated K+ channel (IK-1) in biliary epithelium

Dutta AK, Khimji AK, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP Am J Physiol Gastrointest Liver Physiol 2009 297 G1009-G1018

Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor mediated IP3 and Ca2+ release

Dutta AK, Woo K, Doctor RB, Fitz JG, Feranchak AP Am J Physiol Gastrointest Liver Physiol 2008 295 G1004-G1015

Fluid-flow induces mechanosensitive ATP release, calcium signaling, and Cl- transport in biliary epithelial cells through a PKCzeta-dependent mechanism

Woo K, Dutta A, Patel V, Kresge C, Feranchak AP J Physiol 2008 586 2779-2798

• American Association for the Study of Liver Disease
• American Gastroenterological Association
• American Physiological Society
• North American Society of Pediatric Gastroenterology and Nutrition
• Society of Pediatric Research