Andrew Feranchak, M.D., is a graduate of the University of Notre Dame and the University of Pittsburgh Medical School. He completed his internship and residency in Pediatrics at The Children’s Hospital in Pittsburgh and his fellowship in Pediatric Gastroenterology, Hepatology, and Nutrition at the University of Colorado Health Sciences and Children’s Hospital Denver.
Dr. Feranchak’s clinical interests include cholestatic liver disease, assessment of nutritional and fat-soluble vitamin status, and gastrointestinal and liver complications of cystic fibrosis. His basic research interests include understanding the mechanisms of bile formation, biliary secretion, and liver cell volume regulation.
He is the winner of the American Liver Foundation Postdoctoral Research Fellowship Award, the North American Society Pediatric Gastroenterology and Nutrition Fellow Research Award, the Children’s Digestive Health and Nutrition Foundation Silver Anniversary Award, and the Regal Award for excellence in gastroenterology and liver research.
He is presently an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and the Children’s Medical Center, Dallas, Texas.
|Medical School||Univ. of Pittsburgh School of Medicine (1992)|
|Residency||Children's Hospital of Philadelphia (1995), Pediatrics|
|Fellowship||University of Colorado Health Sciences Center (1998), Pediatric Gastroenterology|
|Research Fellowship||University of Colorado Health Science Center (1999), Hepatology|
- Cystic Fibrosis (CF)
- Liver Disease
- Biophysical characterization of membrane ion channels
- Cell volume regulation
- Cholestatic liver disease
- Hepatobiliary transport
- Mechanisms of bile formation
- Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A.
- Dutta AK, Woo K, Khimji AK, Kresge C, Feranchak AP Am. J. Physiol. Gastrointest. Liver Physiol. 2013 Jan 304 1 G87-98
- Regulation of Purinergic Signaling in Biliary Epithelial Cells by Exocytosis of SLC17A9-dependent ATP-enriched Vesicles.
- Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP J. Biol. Chem. 2011 Jul 286 28 25363-76
- Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.
- Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP J. Biol. Chem. 2011 Jan 286 1 766-76
- ATP release and P2 receptor-mediated secretion in small and large mouse cholangiocytes
- Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser S, Alpini G, Feranchak AP Hepatology 2010 52 1819-1828
- Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium
- Feranchak AP, Lewis MA, Kresge C, Sathe M, Bugde A, Luby-Phelps K, Antich P, Fitz JG J Biol Chem 2010 285 8138-47
- Fluid-flow induces mechanosensitive ATP release, calcium signaling, and Cl- transport in biliary epithelial cells through a PKCzeta-dependent mechanism
- Woo K, Dutta A, Patel V, Kresge C, Feranchak AP J Physiol 2008 586 2779-2798
- Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion.
- Geisler JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C Endocrinology 2013 Feb 154 2 675-84
- Identification and functional characterization of the intermediate conductance Ca2+-activated K+ channel (IK-1) in biliary epithelium
- Dutta AK, Khimji AK, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP Am J Physiol Gastrointest Liver Physiol 2009 297 G1009-G1018
- Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor mediated IP3 and Ca2+ release
- Dutta AK, Woo K, Doctor RB, Fitz JG, Feranchak AP Am J Physiol Gastrointest Liver Physiol 2008 295 G1004-G1015
- Thinking outside the cell: the role of extracellular adenosine triphosphate in bile formation.
- Feranchak AP, Fitz JG Gastroenterology 2007 Nov 133 5 1726-8
- American Association for the Study of Liver Disease
- American Gastroenterological Association
- American Physiological Society
- North American Society of Pediatric Gastroenterology and Nutrition
- Society of Pediatric Research