Biography

Andrew Feranchak, M.D., is a graduate of the University of Notre Dame and the University of Pittsburgh Medical School. He completed his internship and residency in Pediatrics at The Children’s Hospital in Pittsburgh and his fellowship in Pediatric Gastroenterology, Hepatology, and Nutrition at the University of Colorado Health Sciences and Children’s Hospital Denver.

Dr. Feranchak’s clinical interests include cholestatic liver disease, assessment of nutritional and fat-soluble vitamin status, and gastrointestinal and liver complications of cystic fibrosis. His basic research interests include understanding the mechanisms of bile formation, biliary secretion, and liver cell volume regulation.

He is the winner of the American Liver Foundation Postdoctoral Research Fellowship Award, the North American Society Pediatric Gastroenterology and Nutrition Fellow Research Award, the Children’s Digestive Health and Nutrition Foundation Silver Anniversary Award, and the Regal Award for excellence in gastroenterology and liver research.

He is presently an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and the Children’s Medical Center, Dallas, Texas.

Education

Medical School
University of Pittsburgh School of Medicine (1992)
Residency
Children's Hospital of Pittsburgh (1995), Pediatrics
Fellowship
University of Colorado Health Sciences Center (1998), Pediatric Gastroenterology
Research Fellowship
University of Colorado Health Science Center (1999), Hepatology

Specialty Areas

Clinical Interest

  • Cystic Fibrosis (CF)
  • Liver Disease

Research Interest

  • Biophysical characterization of membrane ion channels
  • Cell volume regulation
  • Cholestatic liver disease
  • Hepatobiliary transport
  • Mechanisms of bile formation

Publications

Featured Publications LegendFeatured Publications

Vesicular nucleotide transporter-mediated ATP release regulates insulin secretion.
Geisler JC, Corbin KL, Li Q, Feranchak AP, Nunemaker CS, Li C Endocrinology 2013 Feb 154 2 675-84
Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A.
Dutta AK, Woo K, Khimji AK, Kresge C, Feranchak AP Am. J. Physiol. Gastrointest. Liver Physiol. 2013 Jan 304 1 G87-98
Requirements for efficient correction of ?F508 CFTR revealed by analyses of evolved sequences.
Mendoza JL, Schmidt A, Li Q, Nuvaga E, Barrett T, Bridges RJ, Feranchak AP, Brautigam CA, Thomas PJ Cell 2012 Jan 148 1-2 164-74
Regulation of Purinergic Signaling in Biliary Epithelial Cells by Exocytosis of SLC17A9-dependent ATP-enriched Vesicles.
Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP J. Biol. Chem. 2011 Jul 286 28 25363-76
Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.
Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP J. Biol. Chem. 2011 Jan 286 1 766-76
Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes.
Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser SS, Alpini G, Feranchak AP Hepatology 2010 Nov 52 5 1819-28
Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium.
Feranchak AP, Lewis MA, Kresge C, Sathe M, Bugde A, Luby-Phelps K, Antich PP, Fitz JG J. Biol. Chem. 2010 Mar 285 11 8138-47
Identification and functional characterization of the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) in biliary epithelium.
Dutta AK, Khimji AK, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP Am. J. Physiol. Gastrointest. Liver Physiol. 2009 Nov 297 5 G1009-18
Selective toxin sequestrants for the treatment of bacterial infections.
Simpson LS, Burdine L, Dutta AK, Feranchak AP, Kodadek T J. Am. Chem. Soc. 2009 Apr 131 16 5760-2
Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor-mediated IP3 and Ca2+ release.
Dutta AK, Woo K, Doctor RB, Fitz JG, Feranchak AP Am. J. Physiol. Gastrointest. Liver Physiol. 2008 Nov 295 5 G1004-15

Professional Associations/Affiliations

  • American Association for the Study of Liver Disease
  • American Gastroenterological Association
  • American Physiological Society
  • North American Society of Pediatric Gastroenterology and Nutrition
  • Society of Pediatric Research