Cell biology. The unusual case of Porcupine.
Lum L, Clevers H Science 2012 Aug 337 6097 922-3
Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine.
Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L J. Biol. Chem. 2012 Jun 287 27 23246-54
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ Development 2011 Apr 138 7 1247-57
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways.
Dodge ME, Lum L Annu. Rev. Pharmacol. Toxicol. 2011 Feb 51 289-310
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L Sci Signal 2011 4(157) ra4
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L PNAS July 2008 105(28) 9697-9702
Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer
Chen B, Dodge M, Tang W, Lu J, Ma Z, Fan C-W, Wei S, Hao W, Kilgore J, Williams N, Roth M, Amatruda J, Chen C, and Lum L. Nature Chemical Biology January 2008
Deconstructing the Hedgehog pathway in development and disease
Jacob L and Lum L Science October 2007 318 66-8
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
Lum L, Zhang C, Oh S, Mann R, Von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA Mol Cell November 2003 12 1261-1274
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA Science March 2003 299 (5615) 2039-45