Education

Graduate School Cornell University Medical College (1999)

Research Interest

  • Hedgehog and Wnt signaling
  • signal transduction networks
  • stem cell biology
  • tumor suppressors and oncogenes

Publications

Featured Publications LegendFeatured Publications

Signaling: Making a leaner hedgehog

Fan C-W, Tuladhar R, and Lum L Nat Chem Biol 2013 4 9 217-8

A multiplexed luciferase-based screening platform for interrogating cancer-associated signal transduction in cultured cells

Kulak O and Lum L J Vis Exp 2013

Cell biology. The unusual case of Porcupine.

Lum L, Clevers H Science 2012 Aug 337 6097 922-3

Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L J. Biol. Chem. 2012 Jun 287 27 23246-54

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ Development 2011 Apr 138 7 1247-57

Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways.

Dodge ME, Lum L Annu. Rev. Pharmacol. Toxicol. 2011 Feb 51 289-310

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L Sci Signal 2011 4(157) ra4

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L PNAS July 2008 105(28) 9697-9702

Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer

Chen B, Dodge M, Tang W, Lu J, Ma Z, Fan C-W, Wei S, Hao W, Kilgore J, Williams N, Roth M, Amatruda J, Chen C, and Lum L. Nature Chemical Biology January 2008

Deconstructing the Hedgehog pathway in development and disease

Jacob L and Lum L Science October 2007 318 66-8

Honors & Awards

  • American Cancer Society Research Scholar
    (2007)
  • Virginia Murchison Linthicum Scholar in Medical Research
    University of Texas Southwestern Medical Center (2005)
  • Life Sciences Research Foundation Fellowship
    Post doctoral Fellowship (2000)
  • Dean’s Research Award
    Cornell University Medical College (1994)
  • Grace Fimognari Memorial Award
    University of California, Berkeley (1993)