Asaithamby Aroumougame, Ph.D.

Assistant Professor

Department: Radiation Oncology

Graduate Programs: Cancer Biology

Biography

Download Curriculum Vitae

 

Asaithamby Aroumougame (a.k.a Thambi), Ph.D.                                  

 

DEMOGRAPHIC AND PERSONAL INFORMATION

 

Current Appointments

Assistant Professor

Division of Molecular Radiation Biology                                           

Department of Radiation Oncology

University of Texas Southwestern Medical Center at Dallas

 

Contact Information

Department of Radiation Oncology

2201 Inwood Road, NC7.214E                                                                       

Dallas, TX 75390                                                                               

Phone: (214) 648-5175

E-mail: Asaithamby.Aroumougame.@UTsouthwestern.edu

 

Education and Training

2000-2004   Postdoctoral Research Fellow, Lawrence Berkeley National Laboratory, Berkeley, California; Cancer Biology and DNA damage repair

1994-1999   Ph.D.  Banaras Hindu University, India; Cellular and Molecular Biology

1993            M.Phil. Pondicherry University, India; Reproductive Endocrinology

1992            M.S.    Pondicherry University, India; Animal Sciences

1990            B.S.     Pondicherry University, India; Animal Sciences

 

Professional Experience

2013-      Assistant Professor (Tenure accruing Track), Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Texas.

2009-2013 Assistant Professor (Research Track), Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Texas, Advisor: David J. Chen

2004-2008    Instructor (Junior Faculty), Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Texas, Advisor: David J. Chen

2002-2004   Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California, Advisor: David J. Chen

2000-2001 Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California, Advisor: Shyamala G Harris (Deceased)

1944-1999   Graduate Student, University Grants commission of India, Banaras Hindu University, Varanasi, Uttar Pradesh, India, Advisor: Mahendra K Thakur

Education

Graduate School "pondicherry University, India" (), Reproductive Endocrinology
Graduate School Banaras Hindu University - ? (1998)

Research Interests

  • Biological Effects of Galactic Cosmic Rays on Astronauts
  • Fanconi Anemia and Cancer
  • How cells in different phases of the cell cycle recognise and response to stress?
  • Live cell imaging of sub-celluar DNA metablism
  • Replication Stress and Cancer
  • Werner Syndome and Cancer

Publications

Featured Publications Legend

Featured Publications

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice.

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK Cell Rep 2014 Jun

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response.

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA Cell 2014 Apr 157 3 565-79

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells.

Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S, Costes SV Proc. Natl. Acad. Sci. U.S.A. 2012 Jan 109 2 443-8

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.

Chen BP, Li M, Asaithamby A Cancer letters 2011 Dec

Unrepaired clustered DNA lesions induce chromosome breakage in human cells.

Asaithamby A, Hu B, Chen DJ Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 20 8293-8

Unrepaired clustered DNA lesions induce chromosome breakage in human cells.

Asaithamby A, Hu B, Chen DJ PNAS 2011 20 108 8293-8

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture.

Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ NAR 2011 13 39 5474-88

Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.

Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA Biol. Psychiatry 2010 Sep 68 6 503-11

WRN participates in translesion synthesis pathway through interaction with NBS1.

Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ Mech. Ageing Dev. 2010 Jun 131 6 436-44

Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity.

Perry JJ, Asaithamby A, Barnebey A, Kiamanesch F, Chen DJ, Han S, Tainer JA, Yannone SM JBC 2010 33 285 25699-707

Results 1-10 of 17

Professional Associations/Affiliations

  • Radiation Research Society (2012)