Asaithamby Aroumougame, Ph.D.

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Asaithamby Aroumougame (a.k.a. Thambi), Ph.D.                                  

DEMOGRAPHIC AND PERSONAL INFORMATION

Current Appointment

Associate Professor
Department of Radiation Oncology
UT Southwestern Medical Center at Dallas

Contact Information

Division of Molecular Radiation Biology
Department of Radiation Oncology
2201 Inwood Road, NC7.126A                                                                       
Dallas, TX 75390                                                                               
Phone: 214-648-5175
E-mail: asaithamby.aroumougame.@utsouthwestern.edu

Education and Training

2000-2004: Postdoctoral Research Fellow, Lawrence Berkeley National Laboratory, Berkeley, California; Cancer Biology and DNA damage repair

1994-1999: Ph.D., Banaras Hindu University, India; Cellular and Molecular Biology

1993: M.Phil., Pondicherry University, India; Endocrinology

1992: M.S., Pondicherry University, India; Life Sciences

1990: B.S., Pondicherry University, India; Life Sciences

Professional Experience

2020-current: Associate Professor, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. 

2013-2020: Assistant Professor (Tenure-Accruing Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas.

2009-2013: Assistant Professor (Research Track), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen

2004-2008: Instructor (Junior Faculty), Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas. Advisor: David J. Chen

2002-2004: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: David J. Chen

2000-2001: Postdoctoral Fellow, Department of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California. Advisor: Shyamala G Harris (Deceased)

1994-1999: Graduate Student, University Grants Commission of India, Banaras Hindu University, Varanasi, Uttar Pradesh, India. Advisor: Mahendra K Thakur

Undergraduate

Pondicherry University (1990), Animal Science

Graduate School

Pondicherry University (1992), Animal Science

Graduate School

Banaras Hindu University (1999), Molecular & Cell Biology

• DNA damage response signaling in carcinogenesis
• DNA repair factors in immune response and immunotherapy
• DNA replication in tumorigenesis
• Pathophysiology of Premature Aging Syndrome, specifically Werner Syndrome Protein
• Radiotherapy and heart damage
• Space radiation and Astronauts' health

Cellular senescence and lung cancer prognosis

Asaithamby A, Shay JW, Minna JD Translational Lung Cancer Research 2022 Oct 11 1982-1987

NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei

Abdisalaam S, Mukherjee S, Bhattacharya S, Kumari S, Sinha D, Ortega J, Li GM, Sadek HA, Krishnan S, Asaithamby A Nucleic acids research 2022 Mar 50 2681-2699

Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes

Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee S, Szweda LI, Asaithamby A, Sadek HA Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 118

Immunomodulatory effects of radiotherapy

Kumari S, Mukherjee S, Sinha D, Abdisalaam S, Krishnan S, Asaithamby A International journal of molecular sciences 2020 Nov 21 1-29

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Asaithamby A Journal of Biological Chemistry 2020 Aug 295 11144-11160

Pancreatic cancer patients with germline BRCA mutations can benefit from olaparib treatment

Mukherjee S, Asaithamby A Translational Cancer Research 2020 Apr 9 2154-2156

Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy

Karanam NK, Ding L, Aroumougame A, Story MD Translational Research 2020 Mar 217 33-46

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AH, Elnwasany A, Menendez-Montes I, Ensley EL, Bezan Petric U, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WL, Anene-Nzelu CG, Foo RS, Nguyen NU, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA Nature Metabolism 2020 Feb 2 167-178

Isolation of time-dependent DNA damage induced by energetic carbon ions and their fragments using fluorescent nuclear track detectors

McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O’Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO Medical physics 2020 Jan 47 272-281

Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death

Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO International Journal of Radiation Oncology Biology Physics 2019 Dec 105 1119-1125

• Radiation Research Society (2012)