David Chen, Ph.D.

Professor

Department: Radiation Oncology

Graduate Programs: Cancer Biology

Education

Undergraduate National Taiwan University - Taiwan ()
Graduate School University of Missouri-Columbia (1978)

Research Interests

  • DNA damage responses induced by HZE particles in human cells
  • Pathway choice of DNA double-strand break repair
  • The role of DNA-PK in DNA double-strand break repair

Publications

Featured Publications Legend

Featured Publications

Ku recruits XLF to DNA double-strand breaks

48. Yano K, Morotomi-Yano K, Wang SY, Uematsu N, Lee KJ EMBO 2008 9 91-6

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break

Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Lobrich M, Shiloh Y, Chen DJ J Biol Chem 2007 282 6582-7

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

Burma S, Chen BP, Chen DJ DNA Repair 2006 5 1042-8

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA Nat Struct Mol Biol 2006 13 414-22

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ J Biol Chem 2005 280 14709-15

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Honors/Awards

  • NIH MERIT Research Award
    (2003)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Association of cancer Research
  • American Society for Therapeutic Radiology and Oncology
  • American Society of Cell Biology
  • Radiation Research Society