Biography

Dr. Le received his Ph.D. degree in Microbiology, Immunology and Molecular Genetics (with Owen N. Witte), and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA).  He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral fellowship in Cancer Biology (with Luis F. Parada) from University of Texas Southwestern Medical Center.  He is board certified by the American Board of Dermatology.  Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic.

As a principal investigator in cancer biology, his laboratory investigates how genetic and tumor microenvironmental events interplay to regulate carcinogenesis.  His research group focuses on: (1) identifying the cells of origin of tumorigenesis (how do certain type of cancers originate and develop from adult stem/progenitor cells?); and (2) elucidating the roles of tumor microenvironment in cancer development (how do neighboring non-cancerous cells dictate cancer development and progression?). His laboratory dissects these cellular and molecular mechanisms of tumorigenesis from the developmental perspective. They utilize Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model to address these two fundamental questions in cancer biology as well as elucidating cutaneous nervous system development and regeneration.  His major research goals are to understand mechanisms that initiate Neurofibroma genesis and drive their malignant transformation as well as to develop novel therapeutic targets for Neurofibroma.  Research in Dr. Le's laboratory is supported by grants from the National Cancer Institute of the National Institutes of Health as well as grants from the U.S. Department of Defense and the Burroughs Wellcome Fund.

Le Laboratory Website

Education

Graduate School
University of California - Los Angeles (2002), Microbiology, Immunology & Molecular Genetics
Medical School
University of California, Los Angeles (2003)
Internship
Saint Mary's Medical Center-Long Beach (2004), Internal Medicine
Residency
University of Texas Southwestern Medical School (2007), Dermatology
Fellowship
UT Southwestern Graduate School of Biomedical Sciences (2009), Cancer Biology

Clinical Interest

Skin Disorders

  • Acne
  • Biopsies
  • Chronic Cellulitis
  • Eczema
  • Nevi (Moles)
  • Patients with Multiple Moles
  • Pigmented Lesions
  • Previous Skin Cancers
  • Psoriasis
  • Skin Cancers
  • Skin Check
  • Transplant Patients

Treatment of Neurofibromatosis

  • Neurofibromatosis Type 1 (NF1)

Research Interest

  • Cancer Biology
  • Neurofibromatosis
  • Stem Cell Biology

Publications

Featured Publications LegendFeatured Publications

Honors & Awards

  • Elected to membership in the American Society for Clinical Investigation (ASCI)
    (2015)
  • Thomas L. Shields, M.D. Endowed Professorship in Dermatology
    (2015)
  • Elisabeth Reed Wagner Fund for Research and Clinical Care in Neurofibromatosis and Cardiothoracic Surgery
    (2014)
  • U.S. Department of Defense-Investigator Initiated Research Program Awards
    (2014)
  • European Society for Dermatological Research/Society for Investigative Dermatology Collegiality Travel Awards
    (2012)
  • U.S. Department of Defense-Neurofibromatosis Research Program New Investigator Awards
    (2012)
  • Victor Newcomer Award from the Pacific Dermatologic Association
    (2012)
  • Outstanding Teaching Award from Dermatology residents
    (2010)
  • Disease-Oriented Clinical Scholars (DOCS) Award
    (2009)
  • Career Awards for Medical Scientists from the Burroughs Wellcome Fund
    (2008)
  • President's Research Council Distinguished Young Researcher Award (UTSW)
    (2008)
  • The American Academy of Dermatology Young Investigator Award
    (2008)
  • The Dermatology Foundation Physician Scientist Career Development Award
    (2008)

Professional Associations/Affiliations

  • American Society for Clinical Investigation (ASCI) (2015)
  • American Association for Cancer Research (AACR) (2013)
  • Leaders Society - Dermatology Foundation (2013)
  • Texas Dermatological Society
  • The American Academy of Dermatology
  • The Society for Investigative Dermatology
  • UCLA Association of Chemists and Biochemists