David Hendrixson, Ph.D. Titles and Appointments Professor School Medical School Department Microbiology Graduate Programs Molecular Microbiology Biography My research program is involved in analyzing genetics of bacteria and requirements of bacteria to interact with appropriate hosts. The primary research interests of the laboratory are focused towards Campylobacter jejuni, a leading cause of diarrheal disease throughout the world, and Helicobacter pylori, a primary cause of gastritis, gastric ulcers, and gastric cancer. My laboratory identifies factors required by these bacteria for infection of hosts and analyzes the regulated expression of these factors. Further detalis regarding my research program can be found at here. Education Undergraduate Univ Arkansas Fayetteville (1994), Microbiology Graduate School Washington Univ-Sch of Medicin (1999), Microbiology Research Interest Bacterial Genetics Bacterial Pathogenesis Bacterial sensing and signal transduction Bacterial-Host Interactions Campylobacter jejuni Publications Featured Publications The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction. Ruiz N, Xing J, Zhulin IB, Brautigam CA, Hendrixson DR, mBio 2024 Dec e0327824 FlaG competes with FliS-flagellin complexes for access to FlhA in the flagellar T3SS to control Campylobacter jejuni filament length. Waller AA, Ribardo DA, Hendrixson DR, Proc Natl Acad Sci U S A 2024 Oct 121 44 e2414393121 Viscosity-dependent determinants of Campylobacter jejuni impacting the velocity of flagellar motility. Ribardo DA, Johnson JJ, Hendrixson DR, mBio 2023 Dec e0254423 Campylobacter jejuni BumSR directs a response to butyrate via sensor phosphatase activity to impact transcription and colonization. Goodman KN, Powers MJ, Crofts AA, Trent MS, Hendrixson DR, Proc. Natl. Acad. Sci. U.S.A. 2020 May 117 21 11715-11726 A Polar Flagellar Transcriptional Program Mediated by Diverse Two-Component Signal Transduction Systems and Basal Flagellar Proteins Is Broadly Conserved in Polar Flagellates. Burnham PM, Kolar WP, Hendrixson DR, mBio 2020 Mar 11 2 Diversification of Campylobacter jejuni Flagellar C-Ring Composition Impacts Its Structure and Function in Motility, Flagellar Assembly, and Cellular Processes. Henderson LD, Matthews-Palmer TRS, Gulbronson CJ, Ribardo DA, Beeby M, Hendrixson DR, mBio 2020 Jan 11 1 A Chaperone for the Stator Units of a Bacterial Flagellum. Ribardo DA, Kelley BR, Johnson JG, Hendrixson DR, MBio 2019 Aug 10 4 Campylobacter jejuni: collective components promoting a successful enteric lifestyle. Burnham PM, Hendrixson DR Nat. Rev. Microbiol. 2018 Jun Microbiota-Derived Short-Chain Fatty Acids Modulate Expression of Campylobacter jejuni Determinants Required for Commensalism and Virulence. Luethy PM, Huynh S, Ribardo DA, Winter SE, Parker CT, Hendrixson DR MBio 2017 May 8 3 Diverse high-torque bacterial flagellar motors assemble wider stator rings using a conserved protein scaffold. Beeby M, Ribardo DA, Brennan CA, Ruby EG, Jensen GJ, Hendrixson DR Proc. Natl. Acad. Sci. U.S.A. 2016 Mar 113 13 E1917-E1926 Results 1-10 of 34 1 2 3 4 Next Last
