Biography

2014 - present Associate Professor, Dept. of Biochemistry, UT Southwestern

2010 – 2014 Assistant Professor, Dept. of Biochemistry and Internal Medicine, UT Southwestern

2004 - 2010 Assistant Professor, Dept. of Internal Medicine, UT Southwestern

1999 - 2004 Postdoctoral Fellow in Professor Ellenberger’s group, Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

1998 - 1999 Postdoctoral Fellow in Professor Hakoshima’s group at Dept. of Molecular Biology, Nara Institute of Science and Technology

Education

Graduate School Osaka University - Japan (1994), Pharmaceutical Science
Graduate School "nara Institute of Science and Technology, Japan" (1998)

Research Interest

  • Amyloid-like fiber
  • Biochemistry
  • Fluorescent microscopy
  • Protein-protein and protein-RNA/DNA interaction
  • RNA granules
  • RNA regulation
  • X-ray crystallography

Publications

Featured Publications LegendFeatured Publications

Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate and Radicicol.
Kato, M., Li, J., Chuang, J. L. and Chuang, D. T. Structure. 2007 15 992-1004
A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain α-ketoacid dehydrogenase complex.
Kato, M., Wynn, R. M., Chuang, J. L., Brautigam, C. A., Custorio, M. and Chuang, D. T. EMBO J. 2006 25 5983-5994
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
Kato, M., Chuang, J. L., Tso, C.-S., Wynn, R. M. and Chuang, D. T. EMBO J 2005 24 1763-1774
Molecular mechanism for regulation of the human mitochondrial branched-chain α-ketoacid dehydrogenase complex by phosphorylation.
Wynn, R. M., Kato, M., Machius, M., Chuang, J. L., Li, J., Tomchick, D. R., and Chunag, D. T. Structure 2004 12 2185-96
Modular Architecture of the Bacteriophage T7 Primase Couples RNA Primer Synthesis to DNA Synthesis
Kato, M., Ito, T., Wagner, G., Richardson, C. C. and Ellenberger, T Molecular Cell 2003 11 1349-1360
Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB
Kato, M., Mizuno, T., Shimizu, T. and Hakoshima, T Cell 1997 88 717-723

Honors & Awards

  • HFSP Young Investigators Award
    (2008)
  • 20th International Union of Biochemistry and Molecular Biology (IUBMB) congress Young Scientist Program
    (2006)
  • Uehara Memorial Foundation
    (2001)
  • Japan Society for the Promotion of Science for Abroad
    (1999)
  • Japan Society for the Promotion of Science for Young Scientists
    (1996)