Education

Medical School Cornell University Medical College (1986)

Specialty Areas

Clinical Interest

  • Internal Medicine

Research Interest

  • Functions of autophagy in health and disease
  • Molecular regulation of autophagy

Publications

Featured Publications LegendFeatured Publications

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance.

Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, Grishin NV, Peyton M, Minna J, Bhagat G, Levine B Cell 2013 Sep 154 6 1269-84

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B Cell 2013 Aug

Identification of a candidate therapeutic autophagy-inducing peptide.

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B Nature 2013 Feb 494 7436 201-6

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.

Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B Science 2012 Nov 338 6109 956-9

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.

He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B Nature 2012 Jan 481 7382 511-5

Image-based genome-wide siRNA screen identifies selective autophagy factors.

Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B Nature 2011 Dec 480 7375 113-7

Autophagy in the pathogenesis of disease.

Levine B, Kroemer G Cell 2008 Jan 132 1 27-42

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B Cell 2005 Sep 122 6 927-39

Autophagy genes are essential for dauer development and life-span extension in C. elegans.

Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B Science 2003 Sep 301 5638 1387-91

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B Nature 1999 Dec 402 6762 672-6

Honors & Awards

  • National Academy of Sciences
    Elected Member (2013)
  • American Association for the Advancement of Science
    Elected Fellow (2012)
  • Howard Hughes Medical Institute
    Investigator (2008)
  • American Association of Physicians
    Elected Member (2005)
  • American Society of Clinical Investigation
    Elected Member (2000)