Beth Levine, M.D.

Professor

Endowed Title: Charles Cameron Sprague Distinguished Chair in Biomedical Science

Department: Internal Medicine, Microbiology

Graduate Programs: Cancer Biology, Molecular Microbiology

Education

Medical School Weill Cornell Graduate School of Medical Science (1986)
Internship Mount Sinai School of Medicine (1987), Internal Medicine
Residency Mount Sinai School of Medicine (1989), Internal Medicine
Fellowship Johns Hopkins University School of Medicine (1992), Infectious Disease

Specialty Areas

Clinical Interests

  • Primary Interests
  • Internal Medicine

Research Interests

  • Autophagy in Cell Death Regulation and Cancer Biology
  • Autophagy in Innate Immunity against Intracellular Pathogens
  • Host-Pathogen Interactions

Publications

Featured Publications Legend

Featured Publications

Identification of a candidate therapeutic autophagy-inducing peptide.

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B Nature 2013 Feb 494 7436 201-6

Autophagy in human health and disease.

Choi AM, Ryter SW, Levine B N. Engl. J. Med. 2013 Feb 368 7 651-62

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.

Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B Science 2012 Nov 338 6109 956-9

Autophagy modulation as a potential therapeutic target for diverse diseases.

Rubinsztein DC, Codogno P, Levine B Nat Rev Drug Discov 2012 Sep 11 9 709-30

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.

He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B Nature 2012 Jan 481 7382 511-5

Image-based genome-wide siRNA screen identifies selective autophagy factors.

Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B Nature 2011 Dec 480 7375 113-7

Autophagy in immunity and inflammation.

Levine B, Mizushima N, Virgin HW Nature 2011 Jan 469 7330 323-35

Autophagy protects against Sindbis virus infection of the central nervous system.

Orvedahl A, MacPherson S, Sumpter R, Tallóczy Z, Zou Z, Levine B Cell Host Microbe 2010 Feb 7 2 115-27

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Honors/Awards

  • Howard Hughes Medical Institute
    Investigator (2008)
  • Ellison Medical Foundation
    Senior Scholars Award (2004)
  • American Cancer Society
    Outstanding Achievement & Contributions to Cancer Research (2003)
  • American Society of Clinical Investigation
    Elected Member (2000)
  • 31st Mallinckrodt Scholar Award
    (1999)