Bret Evers, M.D., Ph.D. Titles and Appointments Associate Professor School Medical School Department Pathology | Ophthalmology Graduate Programs Genetics, Development and Disease, Neuroscience You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Education Fellowship UT Southwestern Medical Center 2017, Ophthalmic Pathology Fellowship UT Southwestern Medical Center 2017, Ophthalmic Pathology Other Post Graduate Training UT Southwestern Medical School (2012) Medical School UT Southwestern Medical Center (2012) Graduate School UT Southwestern Medical School (2012), Medical Scientist Training Program Residency UT Southwestern Medical Center (2014), Anatomic Pathology Fellowship UT Southwestern Medical Center (2016), Neuropathology Research Interest Alzheimer disease Analysis of mouse phenotypes Comparative histopathology Frontotemporal lobar degeneration (FTLD) Lipid biology and lipidomics Medical and graduate student education Neurodegeneration Neuropathology Ophthalmic pathology Publications Featured Publications Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R Acta Neuropathol. 2019 Feb Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R Lancet Neurol 2018 Jun 17 6 548-558 Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency. Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574 Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Invest. Dermatol. 2010 May 130 5 1237-48 Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Clin. Invest. 2006 Sep 116 9 2356-65 Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS J. Clin. Invest. 2005 Sep 115 9 2489-98 Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma. Ji Y, Jiang J, Hu L, Lin P, Zhou M, Hu S, Wang M, Ji Y, Liu X, Yan D, Guo Y, Sathe AA, Evers BM, Xing C, Luo X, Xie Q, Pei W, Zhang Z, Yu H, Cell Res 2025 Sep Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes. Vicente CT, Niranjan T, Coopman E, Faura J, Alidadiani S, Schrauwen C, Matchett BJ, Heeman B, Van den Broeck M, De Coster W, Nguyen T, Lau JS, Baheti S, de Pooter T, De Rijk P, Strazisar M, Baker M, DeJesus-Hernandez M, Finch NA, Pottier C, van Blitterswijk M, Asmann Y, Murray ME, Petrucelli L, King A, Troakes C, Al-Sarraj S, Rissman RA, Hiniker A, Flanagan M, Evers BM, White CL, Cruchaga C, Castellani R, van Rooij JGJ, Mol MO, Seelaar H, van Swieten JC, Oskarsson B, Reichard RR, Nguyen AT, Josephs KA, Petersen RC, Ertekin-Taner N, Boeve BF, Graff-Radford NR, Weckhuysen S, Dickson DW, Rademakers R, Mol Neurodegener 2025 Jul 20 1 80 The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer. Thomas-Jardin S, Suresh S, Arce A, Novaresi N, Deng Q, Stein E, Thomas L, Lewis C, Ahn C, Evers BM, Akbay EA, Salvatierra ME, Lu W, Khan K, Solis Soto LM, Wistuba II, Minna JD, O'Donnell KA, Cancer Res 2025 May Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection. Zhu Z, Lou G, Luo Y, Yihunie K, Hoar J, Daniel JA, Evers BM, Yao C, Wu T, Aging Cell 2025 May e70109 Results 1-10 of 59 1 2 3 4 5 Next Last Books Featured Books Mass effect and edema. In Neuropathologic and Neuroradiologic Correlations: A differential diagnostic text and atlas Evers, B., Danielsen, T., and Kumar, M. (2017). Cambridge, UK, Cambridge University Press Honors & Awards Carl B. and Florence E. King Foundation Endowed Fund in Alzheimer's Disease Research Award (2015-2017) Vernie A. Stembridge, M.D., Scholarship Award in Pathology (UT Southwestern) (2012) Distinguished Biochemistry Research Scholar (Texas A&M University) (2004) Barry M. Goldwater Scholar (2002) Bruce D. Fallis, M.D., Resident Award for Teaching (UT Southwestern)2013 and 2014 Commencement Marshal for the Medical School Classes of 2022, 2023, 2024, and 2025 Outstanding Teacher Award (UT Southwestern Medical School)2017, 2018, 2019, 2020, 2021, 2022, 2024, and 2025 UT Southwestern Academy of Teachers (SWAT) Outstanding Biomedical Science Educator2018 and 2022 Professional Associations/Affiliations American Association of Neuropathologists (2014) Phi Beta Kappa (2004) Sigma Xi (2004) Verhoeff-Zimmerman Society (2019)
