Bret Evers, M.D., Ph.D.

• Alzheimer disease
• Analysis of mouse phenotypes
• Comparative histopathology
• Frontotemporal lobar degeneration (FTLD)
• Lipid biology and lipidomics
• Medical and graduate student education
• Neurodegeneration
• Neuropathology
• Ophthalmic pathology

 Featured Publications

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R Acta Neuropathol. 2019 Feb

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R Lancet Neurol 2018 Jun 17 6 548-558

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.

Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Invest. Dermatol. 2010 May 130 5 1237-48

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G J. Clin. Invest. 2006 Sep 116 9 2356-65

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS J. Clin. Invest. 2005 Sep 115 9 2489-98

High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.

Cai L, Hammond NG, Tasdogan A, Alsamraae M, Yang C, Cameron RB, Quan P, Solmonson A, Gu W, Pachnis P, Kaur M, Chang BK, Zhou Q, Hensley CT, Do QN, Martins Nascentes Melo L, Ubellacker JM, Kaushik A, Clare MG, Alcazar IN, Kurylowicz K, Marcuccilli JD, Allies G, Kutritz A, Klode J, Ramesh V, Rogers TJ, Rao AD, Crentsil HE, Li H, Brister F, McDaniel P, Xu X, Evers BM, Zacharias LG, Sudderth J, Xu J, Mathews TP, Oliver D, Minna JD, Waters J, Morrison SJ, Kernstine KH, Faubert B, DeBerardinis RJ, Cancer Discov 2025 Feb OF1-OF15

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y, Sci Adv 2024 Dec 10 51 eads4750

Alternating magnetic fields (AMF) and linezolid reduce Staphylococcus aureus biofilm in a large animal implant model.

Somawardana IA, Prasad B, Kay W, Hunt C, Adams J, Kawaguchi B, Smith TB, Ashton N, Sadaphal V, Tepper J, Monogue M, Ramirez JI, Jones OD, Shelton JM, Evers BM, Serge R, Pybus C, Williams D, Chopra R, Greenberg DE, J Infect 2024 Sep 89 5 106271

Novel multi-spectral short-wave infrared imaging for assessment of human burn wound depth.

Nunez J, Mironov S, Wan B, Hazime A, Clark A, Akarichi C, Korlakunta S, Mandell S, Arnoldo B, Chan R, Goverman J, Huebinger R, Park C, Evers B, Carlson D, Berenfeld O, Levi B, Wound Repair Regen 2024 Sep

 Featured Books

 Mass effect and edema. In Neuropathologic and Neuroradiologic Correlations: A differential diagnostic text and atlas

Evers, B., Danielsen, T., and Kumar, M. (2017). Cambridge, UK, Cambridge University Press

• Carl B. and Florence E. King Foundation Endowed Fund in Alzheimer's Disease Research Award
  (2015-2017)
• Vernie A. Stembridge, M.D., Scholarship Award in Pathology (UT Southwestern)
  (2012)
• Distinguished Biochemistry Research Scholar (Texas A&M University)
  (2004)
• Barry M. Goldwater Scholar
  (2002)
• Bruce D. Fallis, M.D., Resident Award for Teaching (UT Southwestern)
  2013 and 2014
• Commencement Marshal for the Medical School Classes of 2022, 2023, and 2024
  
• Outstanding Teacher Award (UT Southwestern Medical School)
  2017, 2018, 2019, 2020, 2021, 2022, and 2024
• UT Southwestern Academy of Teachers (SWAT) Outstanding Biomedical Science Educator
  2018 and 2022

• American Association of Neuropathologists (2014)
• Phi Beta Kappa (2004)
• Sigma Xi (2004)
• Verhoeff-Zimmerman Society (2019)