Biography

Download Curriculum Vitae

Education
Graduate School
Taras Shevchenko National Univ (1981), Biology
Graduate School
Taras Shevchenko National Univ (1981), Biochemistry
Graduate School
National Academy of Sciences (1985), Enzymology
Graduate School
National Academy of Sciences (1985), Chemistry

Research Interest
  • Biochemistry, Physiology, and Pathophysiology of the Eye and Adnexa
  • Chemistry, Biochemistry, and Biophysics of Lipids
  • Chemistry, Biochemistry, and Biophysics of the Tear Film and Meibum
  • Drug Discovery
  • Enzymology
  • Genomics and Metabolomics of the Eye and Adnexa
  • Meibomian Gland Studies

Publications
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis
Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EM, Butovich IA, Beutler BA, Ufret-Vincenty RL Communications Biology 2023 Dec 6
Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition
Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C Communications Biology 2023 Dec 6
Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers
Butovich IA, Wilkerson A, Yuksel S International journal of molecular sciences 2023 Sep 24
Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease
Xu X, Wilkerson A, Li G, Butovich IA, Zuo YY Investigative Ophthalmology and Visual Science 2023 Aug 64
Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis
Butovich IA, Wilkerson A, Goggans KR, Belyaeva OV, Kedishvili NY, Yuksel S Journal of Biological Chemistry 2023 Jun 299
Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer liquid chromatography–tandem mass spectrometry study
Butovich IA, Yuksel S, Wilkerson A Journal of Biological Chemistry 2023 Apr 299
Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands
Butovich IA, Wilkerson A International journal of molecular sciences 2022 Jul 23
Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease
Butovich IA, Yuksel S, Leonard B, Gadek T, Polans AS, Albert DM Journal of Ocular Pharmacology and Therapeutics 2021 Dec 37 545-555
Effects of aging on human meibum
Butovich IA, Suzuki T Investigative Ophthalmology and Visual Science 2021 Sep 62
Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands
Butovich IA, Wilkerson A, Yuksel S Journal of Steroid Biochemistry and Molecular Biology 2021 Jul 211

Honors & Awards
  • Current NIH award
    R01EY027349 (2017-2026)
  • NIH R01 research awards (recent)
    R01EY019480; R01EY024324 (2010-2021)
  • The Royal Society of Medicine, London, United Kingdom
    Overseas Fellow (2010)
  • National Academy of Sciences, Ukraine
    Senior Research Fellow, Bioorganic Chemistry (1997)

Professional Associations/Affiliations
  • Association for Research in Vision and Ophthalmology (ARVO) (2005)
  • International Society for Eye Research (ISER) (2014)
  • The American Society for Biochemistry and Molecular Biology (2022)