Jun-Shen Huang, Ph.D.

Assistant Professor

Department: Cell Biology

Graduate Programs: Cancer Biology, Cell Regulation

Education

Undergraduate National Taiwan University - Taiwan (), Chemistry
Graduate School University of California-san Diego (1997)

Research Interests

  • Cancer
  • Cytokine receptor
  • Hematopoiesis
  • Signal transduction
  • Structure-function analysis of protein

Publications

Featured Publications Legend

Featured Publications

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR

Michaely P., Zhao Z., Li W.P., Garuti R., Huang L.J., Hobbs H.H., Cohen J.C. EMBO Journal July 2007 26(14) 3273-82

The Membrane Proximal Region Of The Thrombopoietin Receptor (TpoR) Confers Its High Surface Expression by JAK2-dependent and independent mechanisms

Tong W, Sulahian R, Gross AW, Hendon N, Lodish HF, and Huang L.J. Journal of Biological Chemistry December 2006 281(50) 38930-40

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation via the receptor.

Flint-Ashtamker G., Eisen-Lev R., Cohen J., Huang L.J., and Newmann D. 2002 April 2002 FEBS Letters 518 (1-3) 189-94

The N-terminal domain of Janus Kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

Huang L.J., Constantinescu N. S., and Lodish H. F. Molecular Cell December 2001 8 1327-1338

The Erythropoietic receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif.

Constantinescu N. S., Huang L.J., Nam H. S., and Lodish H. F. Molecular Cell February 2001 7 377-385

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Honors/Awards

  • American Cancer Society Postdoctoral Fellowship
    (2002)
  • Howard Temin Award
    (2002)
  • NIH NRSA Award
    (1998)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Society of Biochemistry and Molecular Biology