Amyn Habib, M.D.

Associate Professor

Department: Neurology & Neurotherapeutics

Graduate Programs: Cancer Biology

Biography

I am interested in the diagnosis and treatment of brain tumors. I am also involved in basic scientific research trying to understand the biology of brain tumors and trying to identify ways to treat patients.

Education

Medical School Dow Medical College - Pakistan (1986)

Research Interests

  • Growth factor signaling in cancer
  • The role of inflammation in gliomagenesis

Publications

Featured Publications Legend

Featured Publications

EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma.

Li L, Puliyappadamba VT, Chakraborty S, Rehman A, Vemireddy V, Saha D, Souza RF, Hatanpaa KJ, Koduru P, Burma S, Boothman DA, Habib AA Oncogene 2013 Dec

An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.

Li L, Chakraborty S, Yang CR, Hatanpaa KJ, Cipher DJ, Puliyappadamba VT, Rehman A, Jiwani AJ, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle SC, Kesari S, Boothman DA, Habib AA Oncogene 2013 Sep

Opposing effect of EGFRWT on EGFRvIII-mediated NF-?B activation with RIP1 as a cell death switch.

Puliyappadamba VT, Chakraborty S, Chauncey SS, Li L, Hatanpaa KJ, Mickey B, Noorani S, Shu HK, Burma S, Boothman DA, Habib AA Cell Rep 2013 Aug 4 4 764-75

Cytoplasmic TRADD confers a worse prognosis in glioblastoma.

Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, Habib AA Neoplasia 2013 Aug 15 8 888-97

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA Cancer Res. 2009 May 69 10 4107-11

The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma.

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA Cancer Res. 2009 Apr 69 7 2809-16

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Honors/Awards

  • Clinical Investigator Award
    National Cancer Institute (1999)