Biography

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Dr. Schneider earned his M.D./Ph.D. degrees in the Medical Scientist Training Program at Yale University School of Medicine and Graduate School. He completed his internal medicine and cardiovascular diseases training at Brigham and Women’s Hospital while doing postdoctoral research at Harvard Medical School (Brigham and Women’s Hospital, Children’s Hospital and Dana-Farber Cancer Institute). He was on staff at Brigham and Women’s Hospital and the West Roxbury VA Medical Center in Boston until moving to UT Southwestern Medical Center in Dallas in 2003.

Currently, he is a tenured Associate Professor of Medicine at UT Southwestern Medical Center. His area of interest is chemical biology and drug discovery/development with a focus on stem cell-modulator small molecules that regulate heart repair, adult neurogenesis, and pancreatic β-cell function. Dr. Schneider, along with Drs. Eric Olson and Joseph Hill, is co-PI/co-director of three large national or Texas-wide consortium grants focused on developing novel therapeutics for heart repair after ischemic or cancer chemotherapy related heart injury (AHA-DeHaan Cardiac Myogenesis Research Center, NIH/NHLBI U01 Progenitor Cell Biology Consortium Hub and CPRIT MIRA). Recently, Dr. Schneider was appointed to the “Dallas Heart Ball Endowed Chair in Cardiac Research,” established in 1997 from proceeds of the “Dallas Heart Ball” to promote research, treatment and cure of heart disease. 

Dr. Schneider's research program targets the molecular mechanism of cell fate in stem cells, with a focus on cell signaling, transcriptional regulatory and epigenetic pathways. His lab identified a collection of structurally diverse and chemically interesting small molecules from a high throughput screen of the UTSW chemical library. These small molecules can instruct stem cells in fate decisions, providing an exciting new toolbox to explore mechanisms, and also providing the starting points for novel regenerative drug discovery.

In addition to cardiac fate and developmental mechanisms, is following the chemical biology of these molecules into neuronal fate mechanisms and the biology of the neural cancer stem cell. His research interests include stem cells, cardiomyocytes, chemical genetics/small molecules, neuronal and cancer stem cells, and cell fate mechanisms.

Education

Medical School
Yale University School of Medicine (1989)
Internship
Harvard Medical School/Brigham & Women's Hospital (1990), Internal Medicine
Residency
Harvard Medical School/Brigham & Women's Hospital (1994), Internal Medicine
Fellowship
Harvard Medical School/Brigham & Women's Hospital (1997), Cardiovascular Medicine

Research Interest

  • cardiomyocytes
  • cell fate mechanisms
  • chemical genetics/small molecules
  • neuronal and cancer stem cells
  • stem cells

Publications

Featured Publications LegendFeatured Publications

Neuroscience. Neural stem cells, excited.
Hsieh J, Schneider JW Science 2013 Mar 339 6127 1534-5
Coupling Hippocampal Neurogenesis to Brain pH through Proneurogenic Small Molecules That Regulate Proton Sensing G Protein-Coupled Receptors.
Schneider JW, Goetsch SC, Leng X, Ludwig SM, Russell JL, Yang CP, Zhang QJ ACS Chem Neurosci 2012 Jul 3 7 557-68
Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease.
Russell JL, Goetsch SC, Aguilar HR, Coe H, Luo X, Liu N, van Rooij E, Frantz DE, Schneider JW ACS Chem. Biol. 2012 Jun 7 6 1077-83
Targeting native adult heart progenitors with cardiogenic small molecules.
Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW ACS Chem. Biol. 2012 Jun 7 6 1067-76
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.
Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL Cell 2012 May 149 4 753-67
A small molecule differentiation inducer increases insulin production by pancreatic ß cells.
Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 108 51 20713-8
Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J Differentiation 2011 Apr 81 4 233-42
A dynamic notch injury response activates epicardium and contributes to fibrosis repair.
Russell JL, Goetsch SC, Gaiano NR, Hill JA, Olson EN, Schneider JW Circ. Res. 2011 Jan 108 1 51-9
Cardiotoxicity due to cancer therapy.
Khakoo AY, Liu PP, Force T, Lopez-Berestein G, Jones LW, Schneider J, Hill J Tex Heart Inst J 2011 38 3 253-6
Small-molecule activation of neuronal cell fate.
Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz DE, Hsieh J Nat. Chem. Biol. 2008 Jul 4 7 408-10

Books

Featured Books Legend Featured Books

The molecular biology of the Na,K-ATPase and other genes involved in the ouabain-resistant phenotype. In Molecular Neurobiology: Recombinant DNA Approaches

Levenson, R., Emanuel, J.R., Garetz, S. and Schneider, J. W. (1987). New York, Plenum Press

Molecular cloning of Na+, K+- ATPase ? subunit gene using antibody probes. In Methods in Enzymology, Vol. 156, Biomembranes, Part P, ATP-Driven Pumps and Related Transport: The Na,K-Pump

Schneider, J.W., Mercer, R.W., Benz, E.J., Jr. and Levenson, R. (1988). New York, Academic Press, Inc.

Studies of gene expression during granulocyte maturation. In Tumor Cell Differentiation

Benz, E.J., Jr., High, K.A., Lomax, K., Stolle, C.A., Rado, T.A., Schneider, J.W. and Mercer, R.W. (1987). New York, The Humana Press

In vitro expression of the a- and b- subunits of the Na,K-ATPase. In Progress in Clinical and Biological Research. Vol. 268, The Na+,K+-pump, Part B: Cellular Aspects

Gilmore-Hebert, M., Mercer, R.W., Schneider, J.W. and Benz, E.J., Jr. (1988). New York, Alan R. Liss, Inc.

Molecular cloning and characterization of the a-subunit isoforms of the Na,K-ATPase

Mercer, R.W., Schneider, J.W. and Benz, E.J., Jr. (1988). Ibid

Detection of mRNA in frozen tissue sections by in situ hybridization with RNA probes. In Methods in Hematology, Vol. 20: Molecular Genetics

Schneider, J.W. and Utset, M.F. (1989). New York, Churchill Livingstone, Inc.

Retinoblastoma pocket proteins and the terminally differentiated state in muscle cells. In Developmental Mechanisms of Heart Disease

Schneider, J.W., Kaushal, S., Gu, W., Tam, S., Wang, J., Mahdavi, V. and Nadal-Ginard, B. (1995). New York, Future, Inc.

Genetics and epigenetics in adult neurogenesis. In Adult Neurogenesis

Hsieh, J., Schneider, J.W. (2008). New York, Cold Spring Harbor Laboratory Press

Honors & Awards

  • The Dallas Heart Ball
    Endowed Chair for Cardiac Research (2013)
  • UT Southwestern Medical Center Office of Faculty Diversity and Development
    Selected participant, LEAD (Leadership Emerging in Academic Depts.) Program (2012)
  • Daniel Podolsky, MD, President, UT Southwestern Medical Center
    Invited Speaker, President's Research Council (2011)
  • Daniel Podolsky, MD, President, UT Southwestern Medical Center; Mary Ellen Weber, PhD, VP, Government Affairs and Policy
    Thank you letters from President Podolsky and Mary Ellen Weber for giving talks and tours for official legislative guests (2010)
  • Roberto Bolli, MD, Editor-In-Chief, "Circulation Research"
    Top Downloaded Online First Article in "Circulation Research" - "A dynamic Notch injury response activates epicardium and contributes to fibrosis repair" (2010)
  • Francisco G. Cigarroa, MD, Chancellor, The University of Texas System
    Letter of Congratulations from UT Chancellor for U01 award (2009)
  • Astra-Merck, Inc.
    Cardiovascular Young Investigator Award (1996)
  • American Federation of Clinical Research
    Henry Christian Memorial Award for Excellence in Cardiovascular Research (1992)
  • American Federation of Clinical Research
    AFCR Trainee Investigator Award (1992)
  • American Heart Association
    Finalist, Louis N. Katz Prize for Young Investigators (1992)
  • American Federation of Clinical Research
    AFCR Trainee Investigator Award (1991)
  • Merck-American Federation of Clinical Research
    MD/PhD Postdoctoral Fellowship Award (1991)
  • Yale University School of Medicine
    Peter F. Curran Prize for outstanding medical school thesis (1989)

Professional Associations/Affiliations

  • Center for Regenerative Science and Medicine (2014)
  • ACS - Chemical Biology; ACS - Chemical Neuroscience (2012)
  • UT Southwestern Medical Center - 2012 NIH/NHLBI Progenitor Cell Biology 4th Annual Meeting (2012-2012)
  • UT Southwestern Medical Center Department of Internal Medicine - Cardiology (2012)
  • Cell Biochemistry and Function (2011)
  • Texas Medical Board, Austin, TX - Stem Cell Stakeholder's Committee (2011)
  • UT Southwestern Cancer Prevention & Research in Texas, Multi-Investigator Award (2011)
  • UT Southwestern Medical Center - BioCenter (2011)
  • ABCAM/UT Southwestern Medical Center - ABCAM Conference: "Birth, Life and Death of the Cardiac Myocyte" (2010-2010)
  • Cytotherapy (2010)
  • Journal of Cellular Biochemistry (2010)
  • Journal of Medicinal Chemistry (2010)
  • National Institutes of Health (NIH)/NHLBI Progenitor Cell Biology Consortium Steering Committee (2010)
  • San Yatsen University, Guangzhou, Southern China/UT Southwestern Medical Center - Presidential-appointed committee, San Yatsen University-UTSW Post-Doctoral Research Exchange Program (2010-2010)
  • Stem Cells and Development (2010)
  • Texans for Stem Cell Research, Austin, TX (2010)
  • Texas Heart Institute Journal (2010)
  • UT Southwestern Medical Center - American Heart Association - Jon Holden DeHaan Cardiac Myogenesis Research Centers 1st Annual Scientific Retreat (2010-2010)
  • American Heart Association Cardiac Development Study Section (2009)
  • Medical Research Council, Great Britain (U.K.) (ad hoc) (2009)
  • National Institutes of Health Challenge Committee (ad hoc) (2009)
  • New York State Stem Cell Grant Review Committee (NYSTEM) (2009)
  • Ontario Research Fund (Canada) - Global Leadership Round in Genomics & Life Sciences (ad hoc) (2009)
  • UT Southwestern AHA-DeHaan Cardiac Myogenesis Research Center (2009)
  • UT Southwestern Medical Center - Presidential Dignitary Committee (2009)
  • UT Southwestern NIH/NHLBI-U01 Progenitor Cell Biology Consortium Group (2009)
  • UT Southwestern Medical Center - UTSW Cardiovascular Symposium: "Chemical Genetics & Cardiovascular Drug Discovery" (2004-2004)
  • Circulation Research (2003)
  • Journal of Investigative Medicine (2003)
  • Nature Chemical Biology (2003)
  • Proceedings National Academy of Sciences, USA (2003)
  • UT Southwestern Medical Center - monthly Cardiovascular Research Conference (2003)
  • UT Southwestern Medical Center Department of Internal Medicine - Cardiology (2003-2012)
  • UT Southwestern Medical Center Department of Internal Medicine - Cardiology Coronary Care Unit (2003)
  • UT Southwestern Medical Center Department of Internal Medicine - Molecular Biology (2003-2005)
  • VA Boston Healthcare System (West Roxbury) - Coronary Care Unit (2002-2003)
  • Subspecialty Board of Cardiovascular Disease (2001)
  • American Board of Internal Medicine (1998)
  • Brigham & Women's Hospital - Harvard Medical School (1997-2003)
  • Brigham & Women's Hospital - Harvard Medical School (1997-2003)
  • Brigham & Women's Hospital, Cape Cod Hospital - BWH Cardiology Moonlighting Service (1997-2003)
  • Cape Cod Hospital, Hyannis & Falmouth Hospital (Falmouth, MA) Departments of Internal Medicine (1997-2003)
  • VA Boston Healthcare System (West Roxbury) Department of Internal Medicine (1997-2003)
  • West Roxbury VA Medical Center - Cardiology Grand Rounds (1997-2003)
  • Brigham & Women's Hospital - Harvard Medical School (1994-1997)
  • Brigham & Women's Hospital - Harvard Medical School Department of Internal Medicine (1991-1994)
  • Children's Hospital (Harvard Medical School, HMS); Brigham & Women's Hospital (HMS); Dana-Farber Cancer Institute (HMS) (1991-1997)
  • Brigham & Women's Hospital - Harvard Medical School Department of Internal Medicine (1990-1991)