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Dr. Joshua Koch is interested in better understanding acquired brain injury and how improved care in the intensive care unit can prevent it. He serves as the site primary investigator for the multi-center trial, Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA). This trial is funded by the National Heart, Lung, and Blood Institute and began enrollment on September 1, 2009. He is the site primary investigator for a multi-center trial aimed at better understanding the prevalence of neurologic injury, entitled Prevalence of Acute critical Neurologic disease in children: a Global Epidemiological Assessment (PANGEA). He is also primary investigator for the project, Prospective Analysis of Regional Cerebral Perfusion Using Head Ultrasound and Multi-Source-Detector Near Infrared Spectroscopy (NIRS) Imaging (funding by NCTCTSI).
His other research efforts focus on optimizing the post-operative management of patients with congenital heart disease. He is the primary investigator for a study looking at the use of tolvaptan in pediatric patients with hyponatremia and heart failure. He is a co-investigator on the CHANGE study (Congenital Heart And AdreNal Gland Examination) and a study on post-operative pacing, entitled “Temporary atrial pacing improves cardiac output following pediatric cardiac surgery”.