Dr. Joshua Koch is interested in better understanding acquired brain injury and how improved care in the intensive care unit can prevent it. He serves as the site primary investigator for the multi-center trial, Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA). This trial is funded by the National Heart, Lung, and Blood Institute and began enrollment on September 1, 2009. He is the site primary investigator for a multi-center trial aimed at better understanding the prevalence of neurologic injury, entitled Prevalence of Acute critical Neurologic disease in children: a Global Epidemiological Assessment (PANGEA). He is also primary investigator for the project, Prospective Analysis of Regional Cerebral Perfusion Using Head Ultrasound and Multi-Source-Detector Near Infrared Spectroscopy (NIRS) Imaging (funding by NCTCTSI).
His other research efforts focus on optimizing the post-operative management of patients with congenital heart disease. He is the primary investigator for a study looking at the use of tolvaptan in pediatric patients with hyponatremia and heart failure. He is a co-investigator on the CHANGE study (Congenital Heart And AdreNal Gland Examination) and a study on post-operative pacing, entitled “Temporary atrial pacing improves cardiac output following pediatric cardiac surgery”.
|Medical School||University of Kansas School of Medicine (2001)|
|Internship||UT Southwestern / Children's Medical Center (2002), Pediatrics|
|Residency||UT Southwestern / Children's Medical Center (2004), Pediatrics|
|Residency||UT Southwestern / Children's Medical Center (2005), Pediatrics|
|Fellowship||UT Southwestern / Children's Medical Center (2008), Pediatric Critical Care Medicine|
- Neurocritical Care
- Adrenal function in children with congenital heart disease
- Neurologic outcomes in children with congenital heart disease
- Team dynamics in the intensive care unit setting
- Protecting the future: neuroprotective strategies in the pediatric intensive care unit.
- Koch JD, Kernie SG Curr. Opin. Pediatr. 2011 Jun 23 3 275-80
- Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury.
- Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG J. Cereb. Blood Flow Metab. 2008 Jul 28 7 1294-306
- Echocardiographic predictors of symptomatic patent ductus arteriosus in extremely-low-birth-weight preterm neonates.
- Ramos FG, Rosenfeld CR, Roy L, Koch J, Ramaciotti C J Perinatol 2010 Aug 30 8 535-9
- Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisis.
- Koch J, Manworren R, Clark L, Quinn CT, Buchanan GR, Rogers ZR Am. J. Hematol. 2008 Sep 83 9 728-31
- Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less.
- Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR Pediatrics 2006 Apr 117 4 1113-21
Honors & Awards
- Southern Society Pediatric Research
Clinical Young Investigator Award (2005)
- Resident Award for Pediatric Research
- D. Cramer Reed Award
Excellence in Public Health (2001)
- Guthrie Excellence in Pediatrics Award
- American Academy of Pediatrics
- Mortar Board National Honor Society