Dr. Chan is interested in both basic and applied studies of the human larynx at many different levels. In particular, the focus is on vocal fold tissue mechanics and biorheology, and their relationships with voice acoustics and laryngeal physiology. Another area of emphasis is tissue engineering and regenerative medicine, where various types of extracellular matrix scaffolds are being developed as tissue replacements for surgical applications.
Our laboratory projects involve the use of cell culture models, animal models, physical models and computer models of the larynx.
- University of Hong Kong , Speech and Hearing Sciences
- Graduate School
- University of Iowa (1998)
- Biomaterials for surgical applications
- Laryngeal physiology, acoustics, and biomechanics
- Solid mechanics (soft tissue mechanics)
- Tissue engineering and regenerative medicine
- Viscoelasticity and biorheology
- A simple-shear rheometer for linear viscoelastic characterization of vocal fold tissues at phonatory frequencies.
- Chan RW, Rodriguez ML Journal of the Acoustical Society of America 2008 124 1207-1219
- A biodegradable, acellular xenogeneic scaffold for regeneration of the vocal fold lamina propria.
- Xu CC, Chan RW, Tirunagari N Tissue Engineering 2007 13 (3) 551-566
- The importance of hyaluronic acid in vocal fold biomechanics
- Chan RW, Gray SD, Titze IR Otolaryngology--Head and Neck Surgery June 2001 124(6) 607-614
- Viscoelastic shear properties of human vocal fold mucosa: Theoretical characterization based on constitutive modeling
- Chan RW, Titze IR Journal of the Acoustical Society of America January 2000 107(1) 565-580
- Hyaluronic acid (with fibronectin) as a bioimplant for the vocal fold mucosa
- Chan RW, Titze IR Laryngoscope July 1999 109(7) 1142-1149
- The human umbilical vein with Wharton’s jelly as an allogeneic, acellular construct for vocal fold restoration.
- Chan RW, Rodriguez ML, McFetridge PS Tissue Engineering Part A (in press).
- A bovine acellular scaffold for vocal fold reconstruction in a rat model.
- Xu CC, Chan RW, Weinberger DG, Efune G, Pawlowski KS Journal of Biomedical Materials Research Part A (in press).
- Biomechanics of fundamental frequency regulation: Constitutive modeling of the vocal fold lamina propria.
- Chan RW, Siegmund T, Zhang K Logopedics Phoniatrics Vocology (in press).
- Relative contributions of collagen and elastin to elasticity of the vocal fold under tension.
- Chan RW, Fu M, Young L, Tirunagari N Annals of Biomedical Engineering 2007 35 1471-1483
- Dependence of phonation threshold pressure on vocal tract acoustics and vocal fold tissue mechanics.
- Chan RW, Titze IR Journal of the Acoustical Society of America 2006 119 2351-2362
Honors & Awards
- Keynote Address
Advances in Quantitative Laryngology Conference, Karolinska Institute, Stockholm, Sweden (2008)
The Mohs Lecture by Placon, Rheology Research Center, University of Wisconsin-Madison, Madison, Wisconsin (2005)
- Acoustical Society of America
- International Society of Biomechanics
- International Society of Biorheology
- Society of Rheology
- Tissue Engineering and Regenerative Medicine International Society