Univ of California-Berkeley (1997), Molecular & Cell Biology
Univ of California-Berkeley (1997), Bioengineering
Graduate School
Stanford University (2002), Biophysics

Research Interest

  • How proteins sense cholesterol in membranes


Featured Publications LegendFeatured Publications

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol.
Infante RE, Radhakrishnan A Elife 2017 Apr 6
Cholesterol-induced conformation changes in the sterol-sensing domain of the scap protein suggest feedback mechanism to control cholesterol synthesis.
Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A J. Biol. Chem. 2017 Apr
Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin.
Chakrabarti RS, Ingham SA, Kozlitina J, Gay A, Cohen JC, Radhakrishnan A, Hobbs HH Elife 2017 Feb 6
Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.
Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A J. Biol. Chem. 2016 Apr
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan SF, Radhakrishnan A, Yan N Science 2015 Jul 349 6244 187-91
Switch-like Responses of Two Cholesterol Sensors Do Not Require Protein Oligomerization in Membranes.
Gay A, Rye D, Radhakrishnan A Biophys. J. 2015 Mar 108 6 1459-69
Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis.
Das A, Brown MS, Anderson DD, Goldstein JL, Radhakrishnan A Elife 2014 Jun e02882
Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells.
Das A, Goldstein JL, Anderson DD, Brown MS, Radhakrishnan A Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 110 26 10580-5
Accessibility of cholesterol in endoplasmic reticulum membranes and activation of SREBP-2 switch abruptly at a common cholesterol threshold.
Sokolov A, Radhakrishnan A J. Biol. Chem. 2010 Sep 285 38 29480-90