Education

Undergraduate University of California-Berkeley (1997), Molecular Cell Biology
Undergraduate University of California-Berkeley (1997), Bioengineering
Graduate School Stanford University (2002), Biophysics

Research Interest

  • Protein Sensors for Membrane Cholesterol
  • Single Molecule Studies of Membrane Proteins in Supported Bilayers

Publications

Featured Publications LegendFeatured Publications

Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells.
Das A, Goldstein JL, Anderson DD, Brown MS, Radhakrishnan A Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 110 26 10580-5
Accessibility of cholesterol in endoplasmic reticulum membranes and activation of SREBP-2 switch abruptly at a common cholesterol threshold.
Sokolov A, Radhakrishnan A J. Biol. Chem. 2010 Sep 285 38 29480-90
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.
Radhakrishnan A, Goldstein JL, McDonald JG, Brown MS Cell Metab. 2008 Dec 8 6 512-21
Composition fluctuations, chemical exchange, and nuclear relaxation in membranes containing cholesterol.
Radhakrishnan A, McConnell H J Chem Phys 2007 May 126 18 185101
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2007 Apr 104 16 6511-8
Theory of the deuterium NMR of sterol-phospholipid membranes.
McConnell H, Radhakrishnan A Proc. Natl. Acad. Sci. U.S.A. 2006 Jan 103 5 1184-9