Biography

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Dr. Todd C. Soesbe joined the faculty at the Advanced Imaging Research Center in January of 2008. He received his Bachelors degree in Physics from Clark University (Worcester, Massachusetts) in 1993. While at Clark, Dr. Soesbe performed several years of undergraduate research with a joint Physics and Chemistry research group lead by Dr. Christopher Landee and Dr. Mark Turnbull. This group designed and synthesized complexes containing transition metals chelated to organic ligands in order to investigate new forms of molecular magnetism, specifically bi-metallic ferrimagnetic materials.

After Clark University, Dr. Soesbe entered Physics graduate school at the University of Texas at Austin in 1997 where he received his Masters in Applied Physics degree in 2000. While at UT Austin, Dr. Soesbe worked with Dr. Karol Lang of the High Energy Physics department on the MINOS project (Main Injector Neutrino Oscillation Search) taking place at Fermilab National Laboratory (Batavia, Illinois). While performing neutrino detector research at UT Austin, Dr. Soesbe became very interested in applying novel high energy physics detector technologies to medical imaging, specifically high-pressure xenon proportional counters for large-volume gamma ray detection in SPECT applications.

From 2000 to 2002, Dr. Soesbe worked for the Optical Networking Division of Lucent Technologies (Richardson, Texas) where he helped develop and test optically based communication technologies for national and global medical data networking. In 2002, Dr. Soesbe returned to graduate school at the University of Texas Southwestern Medical Center at Dallas where he received his Ph.D. in Radiological Sciences in 2007. His graduate research at UT Southwestern, under the guidance of Dr. Peter Antich, focused on the design and development of a small animal SPECT detector that used micro-columnar CsI(Tl) crystals and an electron-multiplying CCD camera for gamma ray detection with photon counting. Dr. Soesbe received a Young Investigator Award for this research from the American Association of Physicists in Medicine in 2007.

Dr. Soesbe’s current research at the Advanced Imaging Research Center involves creating new exogenous contrast agents for molecular imaging applications using MRI. Specifically, for the early detection and diagnosis of cancer. These agents include diamagnetic and paramagnetic chemical exchange saturation transfer agents (DIACEST and PARACEST, respectively), paramagnetic T2 exchange contrast agents, and liposome nanoparticles containing proton shifting agents such as TmDOTMA. He is also involved in the design and fabrication of surface and volume coils for pre-clinical and clinical MRI studies as well as software development for imaging protocols and data analysis.

Education

Undergraduate Clark University (1993), Physics
Graduate School University of Texas at Austin (2000)
Graduate School University of Texas Southwestern Med Ctr Dallas (2007)

Research Interest

  • In vitro imaging of pancreatic beta cells using MR
  • In vivo imaging of CEST and PARACEST MR contrast agents
  • In vivo imaging of liposomal agents using MR
  • MR probe design and construction
  • Preclinical SPECT detector design and construction

Publications

Featured Publications LegendFeatured Publications

(1) H MRS characterization of neurochemical profiles in orthotopic mouse models of human brain tumors.
Hulsey KM, Mashimo T, Banerjee A, Soesbe TC, Spence JS, Vemireddy V, Maher EA, Bachoo RM, Choi C NMR Biomed 2014 Nov
Maximizing T2 -exchange in Dy(3+) DOTA-(amide)X chelates: Fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI.
Soesbe TC, Ratnakar SJ, Milne M, Zhang S, Do QN, Kovacs Z, Sherry AD Magn Reson Med 2014 Jan
Modulation of CEST Images in Vivo by T1 Relaxation: A New Approach in the Design of Responsive PARACEST Agents.
Ratnakar SJ, Soesbe TC, Lumata LL, Do QN, Viswanathan S, Lin CY, Sherry AD, Kovacs Z J. Am. Chem. Soc. 2013 Sep
Multi-Chromatic pH-Activatable (19) F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes.
Huang X, Huang G, Zhang S, Sagiyama K, Togao O, Ma X, Wang Y, Li Y, Soesbe TC, Sumer BD, Takahashi M, Sherry AD, Gao J Angew. Chem. Int. Ed. Engl. 2013 Jun
Characterization of lung cancer by amide proton transfer (APT) imaging: an in-vivo study in an orthotopic mouse model.
Togao O, Kessinger CW, Huang G, Soesbe TC, Sagiyama K, Dimitrov I, Sherry AD, Gao J, Takahashi M PLoS ONE 2013 8 10 e77019
SWIFT-CEST: A new MRI method to overcome T(2) shortening caused by PARACEST contrast agents.
Soesbe TC, Togao O, Takahashi M, Sherry AD Magn Reson Med 2012 Sep 68 3 816-21
Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents
Soesbe TC, Wu YK, and Sherry AD NMR in Biomedicine 2012
pCEST: Positive contrast using Chemical Exchange Saturation Transfer.
Vinogradov E, Soesbe TC, Balschi JA, Dean Sherry A, Lenkinski RE Journal of magnetic resonance (San Diego, Calif. : 1997) 2011 Dec
On-Bead Combinatorial Synthesis and Imaging of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Agents To Identify Factors That Influence Water Exchange.
Napolitano R, Soesbe TC, De Leo´n-Rodri´guez LM, Sherry AD, Udugamasooriya DG Journal of the American Chemical Society 2011 Jul 13023-30
T(2) exchange agents: A new class of paramagnetic MRI contrast agent that shortens water T(2) by chemical exchange rather than relaxation.
Soesbe TC, Merritt ME, Green KN, Rojas-Quijano FA, Sherry AD Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011 May

Honors & Awards

  • The American Association of Physicists in Medicine
    Young Investigator Award (2007)
  • Department of Radiology, UT Southwestern Medical Center
    Fellowship (2005)

Professional Associations/Affiliations

  • American Association of Physicists in Medicine
  • International Society for Magnetic Resonance in Medicine
  • Society of Nuclear Medicine