Download Curriculum Vitae

Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.

Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.

Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG).


Medical School
University of California at San Francisco (1997)
University of California at San Francisco (1998), Pediatrics
University of California at San Francisco (2000), Pediatrics
UT Southwestern Medical Center at Dallas (2005), Pediatric Critical Care Medicine

Specialty Areas

Clinical Interest

  • Brain Injury
  • Research Interest

    • MRI imaging biomarkers of neuronal injury
    • Neural stem cells
    • Traumatic brain injury


    Featured Publications LegendFeatured Publications

    The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury.
    Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR J. Neurosci. 2008 Oct 28 43 10983-9
    Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury.
    Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG J. Cereb. Blood Flow Metab. 2008 Jul 28 7 1294-306
    Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels.
    Shi J, Miles DK, Orr BA, Massa SM, Kernie SG Eur. J. Neurosci. 2007 Jun 25 12 3499-512
    Activation of neural stem and progenitor cells after brain injury.
    Miles DK, Kernie SG Prog. Brain Res. 2006 157 187-197

    Honors & Awards

    • Conferred Thesis Dissertation
      Presented by the University of California San Francisco (1996)
    • Dean’s Prize for Research
      Presented by the University of California San Francisco (1996)
    • Western Society of Pediatric Research Lowell Glasgow Award
      Presented by the University of California San Francisco (1995)
    • Magna cum Laude
      San Jose State University (1993)
    • Minority Access to Research Careers Fellowship
      San Jose State University (1993)

    Professional Associations/Affiliations

    • National Neurotrauma Society
    • Society of Critical Care Medicine
    • Society of Neuroscience