Darryl Miles, M.D.
My academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During my fellowship and as a junior faculty member, I used a transgenic mouse model to investigatye the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. We found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.
I have transitioned to a clinical and transplational appraoch to understanding CNS injury and recovery. I am the lead investigator for an 5 year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. In this study we are investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). We are currently analyzing how the the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term conginitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.
|Medical School||University of California, San Francisco (1997)|
|Internship||University of California at San Francisco (1998), Pediatrics|
|Residency||University of California at San Francisco (2000), Pediatrics|
|Fellowship||UT Southwestern Medical Center at Dallas (2005), Pediatric Critical Care Medicine|
Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts
Miles DK., Kernie SG. Hippocampus April 2008 18(8) 793-806
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders
Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM. Blood December 1996 88(11) 4314-4320
The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury
Miles DK, Chen Y, Hoang T, Shi J, Hurlock E, Kernie SG, Lu R. Journal of Neuroscience October 2008 28(43) 10983-10989
Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury
Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG. Journal of Cerebral Blood Flow and Metabolism July 2008 28(7) 1294-306
Injury induced neurogenesis in Bax- deficient mice: evidence for regulation by voltage-gated potassium channels
Shi J., Miles D.K., Orr B.A., Massa S.A., Kernie S.G European Journal of Neuroscience June 2007 Vol. 25 pp. 3499-3512
Activation of neural stem and progenitor cells after brain injury
Miles D.K., Kernie S.G. Progress in Brain Research Fall 2006 Vol. 157 187-198