Darryl Miles, M.D. Titles and Appointments Associate Professor Schools Medical School Departments Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae Dr. Darryl Miles’ academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During his fellowship and as a junior faculty member, he used a transgenic mouse model to investigate the endogenous capability of neural stem and progenitor cells to remodel the brain after injury. Research found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury. Dr. Miles has transitioned to a clinical and translational approach to understanding CNS injury and recovery. He is the lead investigator for a five-year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury. This study is investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI). Researchers are currently analyzing how the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term cognitive function. Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury. Dr. Miles is also involved in improving the clinical care of pediatric neurocritical care disorders and is a member of the Pediatric Neurocritical Care Research Group (PNCRG). Education Medical School University of California at San Francisco (1997) Internship University of California at San Francisco (1998), Pediatrics Residency University of California at San Francisco (2000), Pediatrics Fellowship UT Southwestern Medical Center (2005), Pediatric Critical Care Medicine Research Interest Cerebral autoregulation Neuroimaging biomarkers Pediatric neurocritical care Quality improvement in pediatric neurocritical care Traumatic brain injury Publications Early Electroencephalogram to Predict Severity of Injury in Infants With Abusive Traumatic Brain Injury Varughese NA, Hasan A, Cohen N, Smith D, Clarke RL, Grapsy J, Said R, Miles D, Raman L, Sirsi D Journal of child neurology 2026 May 41 704-714 The association between neurologic pupillary index (NPi) and functional outcomes in critically ill children McGetrick M, Olson DW, Vashisht A, McCreary M, Kim R, Sinn C, Miles D BMC Pediatrics 2025 Dec 25 Social Environment and Neurobehavioral Outcomes 1 Year After Severe Pediatric TBI in the Intensive Care Unit Author Collaboration TG, Miley AE, Patronick J, Zhang N, Bode RL, Fabio A, Treble-Barna A, Chima RS, Adlam AL, Bell MJ, Wisniewski SR, Beers SR, Wade SL, Kurowski BG, Adlam A, Agbeko R, Au A, Beers S, Butt W, Clark R, Deep A, Edwards R, Ferrazzano P, Figaji A, Kirkwood M, Kong M, LaRovere K, Macintosh I, Mahoney S, Martin LJ, McNally K, Miles D, Morris K, O'Brien N, Pilipenko V, Ramirez JB, Robertson C, Sarnaik A, Schober M, Soto JP, Telling A, Thangarajah H, Thomas NJ, Walson K, West AN, Willyerd A, Zimmerman J Journal of Head Trauma Rehabilitation 2025 May 40 147-156 Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Nguyen L, Miles DK, Harder L, Singh S, Whittemore BA, Greenberg BM, Wang CX Neurology: Neuroimmunology and NeuroInflammation 2023 Oct 11 Reducing central line-associated bloodstream infection in contaminated central venous catheters: Case studies of a pediatric contamination guideline Chamblee TB, Patton LJ, Young VB, Marusich J, Bowens CD, Miles DK British Journal of Nursing 2021 Oct 30 S24-S29 A Prospective Study of Family Engagement for Prevention of Central Line-associated Blood Stream Infections Chamblee TB, Miles DK Pediatric Quality and Safety 2021 Sep 6 E467 Automated Infrared Pupillometer Use in Assessing the Neurological Status in Pediatric Neurocritical Care Patients: Case Reports and Literature Review McGetrick ME, Schneider N, Olson DW, Aiyagari V, Miles D Journal of Child Science 2021 Jun 11 E125-E132 Reducing Central Line-Associated Bloodstream Infection in Contaminated Central Venous Catheters: Case Studies of a Pediatric Contamination Guideline Chamblee TB, Patton LJ, Young VB, Marusich J, Bowens CD, Miles DK JAVA - Journal of the Association for Vascular Access 2021 Jun 26 26-30 Clinical Features, Treatment Strategies, and Outcomes in Hospitalized Children With Immune-Mediated Encephalopathies McGetrick ME, Varughese NA, Miles DK, Wang CX, McCreary M, Monson NL, Greenberg BM Pediatric Neurology 2021 Mar 116 20-26 Predictors of intracranial hypertension in children undergoing ICP monitoring after severe traumatic brain injury Miles DK, Ponisio MR, Colvin R, Limbrick D, Greenberg JK, Brancato C, Leonard JR, Pineda JA Child's Nervous System 2020 Jul 36 1453-1460 Results 1-10 of 28 1 2 3 Next Last Books Featured Books Pediatric Neurocritical Care. In Agrawal A, Britz G, eds. Pediatric Vascular Neurosurgery. Cruz-Navarro J, Miles DK, McDonagh DL. (2016). Springer International Publishing; 57-76. Honors & Awards Conferred Thesis DissertationPresented by the University of California San Francisco (1996) Dean’s Prize for ResearchPresented by the University of California San Francisco (1996) Western Society of Pediatric Research Lowell Glasgow AwardPresented by the University of California San Francisco (1995) Magna cum LaudeSan Jose State University (1993) Minority Access to Research Careers FellowshipSan Jose State University (1993) Professional Associations/Affiliations American Institute for Ultrasound Medicine Pediatric Neurocritical Care Research Group (2009)
