Perixosome proliferators activator receptor - &gamma ligands, 15-deoxy - &Delta-; 12, 14- prostaglandin J2 and ciglitizone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.
B. Zingarelli, M. Sheehan, P. W. Hake, M. O? Connor, A. Denenberg, J. Cook. J Immunol December 2003 15;171(12) 6827-37
Nuclear factor-KB as a therapeutic target in critical care medicine
H. R. Wong, M. Sheehan, B. Zingarelli Critical Care Medicine 2003 31, no. 1
Protective effects of isohelenin, an inhibitor of nuclear factor -KB, in endotoxic shock in rats
M. Sheehan,H.R. Wong, P. W. Hake, B. Zingarelli Journal of Endotoxin Research 2002 8 99-107
Yet another potential role for nitric oxide in the pathophysiology of septic shock
M. Sheehan, H. R. Wong Crit Care Med 2002 Vol. 30, No 6
Parthenolide, an inhibitor of the nuclear factor-KB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
M. Sheehan, H.R. Wong, P. W. Hake, V. Malhotra, M. O' Connor, B. Zingarelli Molecular Pharmacology 2002 61 953-963