Stephen Cannon, M.D., Ph.D.

Associate Dean for Undergraduate Medical Education, Basic Sciences


Endowed Title: Patricia A. Smith Distinguished Chair in Neuromuscular Disease Research, in honor of Gil Wolfe, M.D.

Department: Neurology & Neurotherapeutics, Office of the Dean - Southwestern Medical School

Graduate Programs: Integrative Biology, Neuroscience


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The primary research interests of our laboratory are how ion channels regulate the electrical excitability of cells and how defects in these channels lead to human disease. Electrical signaling is a fundamental mechanism by which cells initiate and regulate contraction of muscles, beating of the heart, secretion of hormones, and communication among neurons. Ion channels are crucial components of the machinery to accomplish this signaling, by forming pores in the cell membrane to allow the passage of electric current. In the past decade, mutations of ion channel genes have been found for inherited diseases that cause episodic paralysis, familial migraine, episodic ataxia, fatal cardiac arrhythmias, and some forms of epilepsy. We have been studying the consequences of mutations in sodium and calcium channels that have been linked to muscle disorders causing episodic paralysis or stiffness (myotonia).


Medical School Johns Hopkins Hospital (1986)
Internship Massachusetts General Hospital (1987), Internal Medicine
Residency Massachusetts General Hospital (1990), Neurology
Fellowship Massachusetts General Hospital (1994), Neurobiology

Research Interests

  • electrophysiology
  • Ion channel physiology
  • mathematical modeling
  • mouse model of muscle disease
  • myotonia
  • periodic paralysis
  • skeletal muscle


Featured Publications Legend

Featured Publications

Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis.

Wu F, Mi W, Cannon SC Brain 2013 Oct

Results 1-10 of 32


  • Patricia A. Smith Distinguished Chair in Neuromuscular Research
  • MERIT Award - NIH
  • Derek Denny-Brown Neurological Scholar Award