Eunsook S. Jin, PhD, is Instructor at the advanced Imaging Research Center and Internal Medicine of UT Southwestern Medical Center. Dr. Jin is interested in intermediary metabolism in vivo using multiple stable isotopes and NMR analysis. She use isolated organ perfusion and intact animal models, and recruit human subjects to study metabolism in the liver, skeletal muscles or the heart. Her research interests are hepatic insulin resistance, hepatic oxidative stress, glucose-fat interaction, obesity, and type 2 diabetes. Most recently she is working on 13C asymmetry in blood glucose released from the liver given [U-13C3]glycerol to determine if the asymmetry is sensitive to hepatic oxidative stress and the pentose phosphate pathway and transaldolase activities in the liver.
|Graduate School||"pusan National University, S. Korea" (1990), Dental Science|
|Graduate School||University of Texas at Dallas (1998)|
|Graduate School||University of Texas at Dallas (2001), Chemistry|
- Glucose-fat metabolic interaction
- Insulin resistance & Type 2 diabetes
- intermediary metabolism
- Reductive carboxylation supports growth in tumour cells with defective mitochondria.
- Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ Nature 2012 Jan 481 7381 385-8
- Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.
- Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR J. Clin. Invest. 2010 May 120 5 1494-505
- The impact of obesity, sex, and diet on hepatic glucose production in cats.
- Kley S, Hoenig M, Glushka J, Jin ES, Burgess SC, Waldron M, Jordan ET, Prestegard JH, Ferguson DC, Wu S, Olson DE Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009 Apr 296 4 R936-43
- Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats. Diabetes
- Jin ES, Park BH, Sherry AD, Malloy CR. Diabetes March 2007 56(3) 777-785
- Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance
- Jin ES, Jones JG, Burgess SC, Merritt ME, Sherry AD, Malloy CR Magn Reson Med June 2005 53(6) 1479-1483
- Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
- Jin ES, Burgess SC, Merritt ME, Sherry AD, Malloy CR Am J Physiol Endocrinol Metab April 2005 288(4) E654-E662
- Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.
- Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD Analytical Biochemistry 2004 327 149-155
- Increased hepatic fructose 2,6 bisphosphate after an oral glucose load does not affect gluconeogenesis
- Jin ES, Uyeda K, Kawaguchi T, Burgess SC, Malloy CR, and Sherry AD Journal of Biological Chemistry 2003 278 28427-28433
Honors & Awards
NIH/NIDDK Mentored Research Scientist Development Award (2008)