Eunsook Jin, Ph.D.

Assistant Professor

Department: Advanced Imaging Research Center, Internal Medicine

Biography

Eunsook S. Jin, PhD, is Instructor at the advanced Imaging Research Center and Internal Medicine of UT Southwestern Medical Center. Dr. Jin is interested in intermediary metabolism in vivo using multiple stable isotopes and NMR analysis. She use isolated organ perfusion and intact animal models, and recruit human subjects to study metabolism in the  liver, skeletal muscles or the heart. Her research interests are hepatic insulin resistance, hepatic oxidative stress, glucose-fat interaction, obesity, and type 2 diabetes. Most recently she is working on 13C asymmetry in blood glucose released from the liver given [U-13C3]glycerol to determine if the asymmetry is sensitive to hepatic oxidative stress and the pentose phosphate pathway and transaldolase activities in the liver. 

Education

Graduate School "pusan National University, S. Korea" (1990), Dental Science
Graduate School University of Texas at Dallas (1998)
Graduate School University of Texas at Dallas (2001), Chemistry

Research Interests

  • Glucose-fat metabolic interaction
  • Insulin resistance & Type 2 diabetes
  • intermediary metabolism
  • NMR

Publications

Featured Publications Legend

Featured Publications

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ Nature 2012 Jan 481 7381 385-8

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice.

Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR J. Clin. Invest. 2010 May 120 5 1494-505

The impact of obesity, sex, and diet on hepatic glucose production in cats.

Kley S, Hoenig M, Glushka J, Jin ES, Burgess SC, Waldron M, Jordan ET, Prestegard JH, Ferguson DC, Wu S, Olson DE Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009 Apr 296 4 R936-43

Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats. Diabetes

Jin ES, Park BH, Sherry AD, Malloy CR. Diabetes March 2007 56(3) 777-785

Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance

Jin ES, Jones JG, Burgess SC, Merritt ME, Sherry AD, Malloy CR Magn Reson Med June 2005 53(6) 1479-1483

Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.

Jin ES, Burgess SC, Merritt ME, Sherry AD, Malloy CR Am J Physiol Endocrinol Metab April 2005 288(4) E654-E662

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.

Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD Analytical Biochemistry 2004 327 149-155

Increased hepatic fructose 2,6 bisphosphate after an oral glucose load does not affect gluconeogenesis

Jin ES, Uyeda K, Kawaguchi T, Burgess SC, Malloy CR, and Sherry AD Journal of Biological Chemistry 2003 278 28427-28433

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Honors/Awards

  • K01
    NIH/NIDDK Mentored Research Scientist Development Award (2008)