Education

Undergraduate University of Tokyo - Japan (1991), Agriculture
Graduate School University of Tokyo - Japan (1993), Agriculture
Graduate School University of Tokyo - Japan (2000), Biology

Research Interest

  • Regulation of estrogen receptor function by oxysterol 27-hydroxycholesterol
  • Role of cholesterol metabolites in cardiovascular and metabolic diseases
  • Role of nuclear receptors in vascular cells

Publications

Featured Publications LegendFeatured Publications

27-hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP Science 2013 Nov 342 6162 1094-8

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth.

Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW Cell Rep 2013 Nov 5 3 637-45

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ Mol. Endocrinol. 2011 Jun 25 6 1066-71

Non-nuclear estrogen receptor signaling in the endothelium.

Wu Q, Chambliss K, Umetani M, Mineo C, Shaul PW J. Biol. Chem. 2011 Apr 286 17 14737-43

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP Endocrinology 2010 Aug 151 8 3675-85

Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.

Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW J. Clin. Invest. 2010 Jul 120 7 2319-30

Honors & Awards

  • American Diabetes Association
    Junior Faculty Award (2011)
  • American Heart Association
    Travel Award for Young Investigators (2010)
  • Kern Aspen Lipid Conference
    Early Career Investigator Award (2010)
  • UTSW O’Brien Kidney Research Center
    Pilot and Feasibility Award (2009)
  • Uehara Memorial Fellowship
    (2002)

Professional Associations/Affiliations

  • American Diabetes Association
  • American Heart Association