Biography

Dr. Zhong studies the biochemical regulation of autophagy in mammalian cells. Autophagy is the crucial waste cleaning system for the cell. Removal of damage organelles, protein aggregates and invading pathogens relies on autophagy. Autophagy is also important for organelle biogenesis and stress response. Dysfunction of autophagy has been implicated in a broad spectrum of human diseases, including cancers, neurodegenerative diseases, infectious diseases and metabolic diseases. During autophagy, a double membrane vesicle termed autophagosome is formed with engulfed cellular cargoes and then fused with lysosomes for degradation. Dr. Zhong is specifically interested in dissecting the biochemical mechanisms in this process including lipid modification, membrane deformation, membrane curvature sensing, cargo recruitment, and membrane tethering/fusion. Understanding the key regulatory steps in this pathway will allow us to develop new therapeutic tools for human diseases. Dr. Zhong also studies cancer drugs induced apoptosis and necrosis, and their interconnection with autophagy.

Education

Medical School Peking Union Medical College - (1995), Medicine
Graduate School University of Texas Health Sci (2001), Medicine

Research Interest

  • Biochemical mechanisms of autophagy
  • DNA damage and HDACi induced apoptosis
  • Primary ciliogenesis
  • Regulated necrosis

Publications

Featured Publications LegendFeatured Publications

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.

Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL Cell 2013 Jan 152 1-2 290-303

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.

Zhong Q, Gao W, Du F, Wang X Cell 2005 Jul 121 7 1085-95

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.

Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH Science 1999 Jul 285 5428 747-50

Honors & Awards

  • Research Scholar
    American Cancer Society (2011)
  • New Scholar in Aging
    The Ellison Medical Foundation (2007)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology (2007)
  • American Society for Cell Biology (2007)