Dr. Chook received an AB degree in Chemistry and Biology (major at Haverford College) from Bryn Mawr College in 1988. She received a PhD in Biophysics in 1994 from Harvard University, where she studied the structures and mechanism of chorismate mutase with William Lipscomb. Her postdoctoral work was with Emil Pai and Tony Pawson in Toronto studying signal transduction in the Ras pathway, and with Günter Blobel at the Rockefeller University studying the mechanisms of nuclear import.
In December of 2001, Dr Chook joined the Department of Pharmacology at UT Southwestern as an Assistant Professor and Eugene McDermott Scholar in Biomedical Research. The Chook laboratory aims to understand mechanisms of nucleocytoplasmic transport by Karyopherinβs (Kapβs), classify nuclear traffic, and discover how Kapβs organize and regulate cellular functions. They seek to discover these roles of Kapβs through a combination of structural, biochemical, biophysical, bioinformatics and cell biological investigations focused on Kapβ-substrate interactions.
|Graduate School||Bryn Mawr College , Chemistry|
|Graduate School||Bryn Mawr College , Biology|
|Graduate School||Harvard University (1993)|
- Cell Biology
- Protein transport, nucleocytoplasmic transport, targeting signals
- Structural Biology
- Atomic basis of CRM1-cargo recognition, release and inhibition.
- Fung HY, Chook YM Semin. Cancer Biol. 2014 Mar
- Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
- Sun Q, Carrasco YP, Hu Y, Guo X, Mirzaei H, Macmillan J, Chook YM Proc. Natl. Acad. Sci. U.S.A. 2013 Jan
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
- Lapalombella R, Sun Q, Williams K, Tangeman L, Jha S, Zhong Y, Goettl V, Mahoney E, Berglund C, Gupta S, Farmer A, Mani R, Johnson AJ, Lucas D, Mo X, Daelemans D, Sandanayaka V, Shechter S, McCauley D, Shacham S, Kauffman M, Chook YM, Byrd JC Blood 2012 Nov 120 23 4621-34
- Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
- Zhang ZC, Chook YM Proc. Natl. Acad. Sci. U.S.A. 2012 Jul 109 30 12017-21
- Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
- Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT Leukemia 2012 Jul
- Structural basis for leucine-rich nuclear export signal recognition by CRM1.
- Dong X, Biswas A, Süel KE, Jackson LK, Martinez R, Gu H, Chook YM Nature 2009 Apr 458 7242 1136-41
- Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals.
- Süel KE, Gu H, Chook YM PLoS Biol. 2008 Jun 6 6 e137
- Structure-based design of a pathway-specific nuclear import inhibitor.
- Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM Nat. Struct. Mol. Biol. 2007 May 14 5 452-4
- Rules for nuclear localization sequence recognition by karyopherin beta 2.
- Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM Cell 2006 Aug 126 3 543-58
- Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.
- Chook YM, Blobel G Nature 1999 May 399 6733 230-7
Chorismate Mutase, essentially a template enzyme. Chapter 17, 235-244.. In Biological NMR Spectroscopy. John L. Markley, Stanley Opella and Richard Ernst (editors).
Lipscomb, W.N., Chook, Y.M. and Ke, H. (1997). Oxford University Press.
Structural Analysis of Karyopherin-mediated nucleocytoplasmic transport.. In Nuclear Transport, edited by Ralph Kehlenbach.
Zhang, Z. C. and Chook, Y. M. (2009). Landes Bioscience.
Honors & Awards
- Leukemia and Lymphoma Society Scholar Award
- Eugene McDermott Scholar in Biomedical Research
U.T. Southwestern Endowed Scholar Award (2001)
- Life Sciences Research Foundation Postdoctoral Fellowship
Rockefeller University (1996)
- Human Frontiers in Science Program Postdoctoral Fellowship
University of Toronto/Mount Sinai Hospital (1994)
- Certificate of Distinction in Teaching
Harvard-Danforth Center for Teaching and Learning, Harvard University (1990)